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The protein encoded by this gene is a member of the ALK/LTK receptor family of receptor tyrosine kinases (RTKs) whose ligand is unknown.[3] Closely related to the insulin receptor family of RTKs. Tyrosine-specific phosphorylation of proteins is a key to the control of diverse pathways leading to cell growth and differentiation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.[2]
↑Maru Y, Hirai H, Takaku F (May 1990). "Human ltk: gene structure and preferential expression in human leukemic cells". Oncogene Res. 5 (3): 199–204. PMID2320375.
Krolewski JJ, Lee R, Eddy R, Shows TB, Dalla-Favera R (1990). "Identification and chromosomal mapping of new human tyrosine kinase genes". Oncogene. 5 (3): 277–82. PMID2156206.
Ben-Neriah Y, Bauskin AR (1988). "Leukocytes express a novel gene encoding a putative transmembrane protein-kinase devoid of an extracellular domain". Nature. 333 (6174): 672–6. doi:10.1038/333672a0. PMID2836739.
Richard I, Broux O, Chiannilkulchai N, Fougerousse F, Allamand V, Bourg N, Brenguier L, Devaud C, Pasturaud P, Roudaut C (1995). "Regional localization of human chromosome 15 loci". Genomics. 23 (3): 619–27. doi:10.1006/geno.1994.1550. PMID7851890.
Kozutsumi H, Toyoshima H, Hagiwara K, Yazaki Y, Hirai H (1994). "Human ltk receptor tyrosine kinase binds to PLC-gamma 1, PI3-K, GAP and Raf-1 in vivo". Oncogene. 9 (10): 2991–8. PMID8084603.
Kozutsumi H, Toyoshima H, Hagiwara K, Furuya A, Mioh H, Hanai N, Yazaki Y, Hirai H (1993). "Identification of the human ltk gene product in placenta and hematopoietic cell lines". Biochem. Biophys. Res. Commun. 190 (2): 674–9. doi:10.1006/bbrc.1993.1101. PMID8427607.
Ueno H, Sasaki K, Kozutsumi H, Miyagawa K, Mitani K, Yazaki Y, Hirai H (1996). "Growth and survival signals transmitted via two distinct NPXY motifs within leukocyte tyrosine kinase, an insulin receptor-related tyrosine kinase". J. Biol. Chem. 271 (44): 27707–14. doi:10.1074/jbc.271.44.27707. PMID8910363.
Snijders AJ, Ho SC, Haase VH, Pillai S, Bernards A (1997). "A lymphocyte-specific Ltk tyrosine kinase isoform is retained in the endoplasmic reticulum in association with calnexin". J. Biol. Chem. 272 (2): 1297–301. doi:10.1074/jbc.272.2.1297. PMID8995435.
Ueno H, Honda H, Nakamoto T, Yamagata T, Sasaki K, Miyagawa K, Mitani K, Yazaki Y, Hirai H (1997). "The phosphatidylinositol 3' kinase pathway is required for the survival signal of leukocyte tyrosine kinase". Oncogene. 14 (25): 3067–72. doi:10.1038/sj.onc.1201153. PMID9223670.
Li N, Nakamura K, Jiang Y, Tsurui H, Matsuoka S, Abe M, Ohtsuji M, Nishimura H, Kato K, Kawai T, Atsumi T, Koike T, Shirai T, Ueno H, Hirose S (2004). "Gain-of-function polymorphism in mouse and human Ltk: implications for the pathogenesis of systemic lupus erythematosus". Hum. Mol. Genet. 13 (2): 171–9. doi:10.1093/hmg/ddh020. PMID14695357.