Legionellosis classification

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] {{AE}]Tarek Nafee, M.D. [2] Ogechukwu Hannah Nnabude, MD

Overview

Legionellosis may be classified into three clinically different diseases, all of which vary in disease presentation, organ system affected, and severity: pulmonary infection (Legionnaires' disease), extrapulmonary infection, and Pontiac fever, which has causes only mild disease. Legionellosis may also be classified based on the causative species.

Classification

Legionellosis may be classified into three types based upon affected organ systems and clinical presentation:

Pulmonary Infection (Legionnaires' Disease)

Legionnaires' disease may further be classified into:

Extrapulmonary Legionella Infection

Legionella can skin infection soft tissue infection, endocarditis, wound infection, joint infection, and graft infection.

Pontiac Fever

  • Pontiac fever produces a mild, self-limiting, non-fatal illness without symptoms or radiologic findings of pneumonia. A comparison of Pontiac fever and Legionnaires' disease is as follows:
Characteristic Legionnaires' disease Pontiac fever
Cause Legionella species Legionella species
Symptoms Pneumonia, cough, fever [4]. Flu-like illness (fever, chills, malaise) without pneumonia [5]
Radiographic evidence of pneumonia Yes [6] [7] No [8]
Incubation period 2-14 days after exposure 24-72 hours after exposure
Attack rate[1] < 5% > 90%
Isolation of organism Possible Never
Outcome Hospitalization common
Case-fatality rate: 5-30% [9]
Hospitalization uncommon
Case-fatality rate: 0% [10]

Microbiological Classification

Legionellosis may also be classified based on the infectious species responsible for the disease. Species of Legionella include:

References

  1. von Baum H, Ewig S, Marre R, Suttorp N, Gonschior S, Welte T; et al. (2008). "Community-acquired Legionella pneumonia: new insights from the German competence network for community acquired pneumonia". Clin Infect Dis. 46 (9): 1356–64. doi:10.1086/586741. PMID 18419436.
  2. Kirby BD, Harris AA (1987). "Nosocomial Legionnaires' disease". Semin Respir Infect. 2 (4): 255–61. PMID 3328895.
  3. Cordes LG, Myerowitz RL, Pasculle AW, Corcoran L, Thompson TA, Gorman GW; et al. (1981). "Legionella micdadei (Pittsburgh pneumonia agent): direct fluoresent-antibody examination of infected human lung tissue and characterization of clinical isolates". J Clin Microbiol. 13 (4): 720–2. doi:10.1128/jcm.13.4.720-722.1981. PMC 273866. PMID 7014621.
  4. Brady MF, Sundareshan V. Legionnaires' Disease. 2021 Jul 18. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan–. PMID: 28613558
  5. Pancer K, Stypułkowska-Misiurewicz H (2003). "[Pontiac fever--non-pneumonic legionellosis]". Przegl Epidemiol. 57 (4): 607–12. PMID 15029835.
  6. Kim KW, Goo JM, Lee HJ, Lee HY, Park CM, Lee CH; et al. (2007). "Chest computed tomographic findings and clinical features of legionella pneumonia". J Comput Assist Tomogr. 31 (6): 950–5. doi:10.1097/RCT.0b013e31804b211d. PMID 18043362.
  7. Muder RR, Yu VL, Parry MF (1987). "The radiologic manifestations of Legionella pneumonia". Semin Respir Infect. 2 (4): 242–54. PMID 3328894.
  8. Tolentino A, Ahkee S, Ramirez J (1996). "Hot tub legionellosis". J Ky Med Assoc. 94 (9): 393–4. PMID 8855593.
  9. Dominguez A, Alvarez J, Sabria M, Carmona G, Torner N, Oviedo M; et al. (2009). "Factors influencing the case-fatality rate of Legionnaires' disease". Int J Tuberc Lung Dis. 13 (3): 407–12. PMID 19275805.
  10. Leoni E, Catalani F, Marini S, Dallolio L (2018). "Legionellosis Associated with Recreational Waters: A Systematic Review of Cases and Outbreaks in Swimming Pools, Spa Pools, and Similar Environments". Int J Environ Res Public Health. 15 (8). doi:10.3390/ijerph15081612. PMC 6121464. PMID 30061526.

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