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{{Infobox_gene}}
{{PBB_Controls
'''T-lymphocyte surface antigen Ly-9''' is a [[protein]] that in humans is encoded by the ''LY9'' [[gene]].<ref name="pmid8537117">{{cite journal | vauthors = Sandrin MS, Henning MM, Lo MF, Baker E, Sutherland GR, McKenzie IF | title = Isolation and characterization of cDNA clones for Humly9: the human homologue of mouse Ly9 | journal = Immunogenetics | volume = 43 | issue = 1–2 | pages = 13–9 | date = Feb 1996 | pmid = 8537117 | pmc =  | doi = 10.1007/bf00186599 }}</ref><ref name="pmid7797269">{{cite journal | vauthors = Kingsmore SF, Souryal CA, Watson ML, Patel DD, Seldin MF | title = Physical and genetic linkage of the genes encoding Ly-9 and CD48 on mouse and human chromosomes 1 | journal = Immunogenetics | volume = 42 | issue = 1 | pages = 59–62 | date = Aug 1995 | pmid = 7797269 | pmc = | doi = 10.1007/BF00164988 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: LY9 lymphocyte antigen 9| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4063| accessdate = }}</ref> LY9 has also recently been designated '''CD229''' ([[cluster of differentiation]] 229).
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = Lymphocyte antigen 9
| HGNCid = 6730
| Symbol = LY9
| AltSymbols =; CD229; SLAMF3; hly9; mLY9
| OMIM = 600684
| ECnumber = 
| Homologene = 1759
| MGIid = 96885
| GeneAtlas_image1 = PBB_GE_LY9_210370_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_LY9_215967_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003674 |text = molecular_function}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0016064 |text = immunoglobulin mediated immune response}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4063
    | Hs_Ensembl = ENSG00000122224
    | Hs_RefseqProtein = NP_001028839
    | Hs_RefseqmRNA = NM_001033667
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 159032552
    | Hs_GenLoc_end = 159064669
    | Hs_Uniprot = Q9HBG7
    | Mm_EntrezGene = 17085
    | Mm_Ensembl = ENSMUSG00000004707
    | Mm_RefseqmRNA = NM_008534
    | Mm_RefseqProtein = NP_032560
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 1
    | Mm_GenLoc_start = 173425307
    | Mm_GenLoc_end = 173444033
    | Mm_Uniprot = Q4VBG4
  }}
}}
'''Lymphocyte antigen 9''', also known as '''LY9''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: LY9 lymphocyte antigen 9| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4063| accessdate = }}</ref> LY9 has also recently been designated '''CD229''' ([[cluster of differentiation]] 229).


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
LY9 has been shown to [[Protein-protein interaction|interact]] with [[SH2D1A]].<ref name=pmid11389028>{{cite journal | vauthors = Sayós J, Martín M, Chen A, Simarro M, Howie D, Morra M, Engel P, Terhorst C | title = Cell surface receptors Ly-9 and CD84 recruit the X-linked lymphoproliferative disease gene product SAP  | journal = Blood | volume = 97 | issue = 12 | pages = 3867–3874 | date = Jun 2001 | pmid = 11389028 | doi = 10.1182/blood.V97.12.3867 }}</ref><ref name=pmid11477068>{{cite journal | vauthors = Morra M, Simarro-Grande M, Martin M, Chen AS, Lanyi A, Silander O, Calpe S, Davis J, Pawson T, Eck MJ, Sumegi J, Engel P, Li SC, Terhorst C | title = Characterization of SH2D1A missense mutations identified in X-linked lymphoproliferative disease patients  | journal = J. Biol. Chem. | volume = 276 | issue = 39 | pages = 36809–36816 | date = Sep 2001 | pmid = 11477068 | doi = 10.1074/jbc.M101305200 }}</ref>
{{PBB_Summary
| section_title =  
| summary_text =  
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA | title = A "double adaptor" method for improved shotgun library construction | journal = Anal. Biochem. | volume = 236 | issue = 1 | pages = 107–113 | year = 1996 | pmid = 8619474 | doi = 10.1006/abio.1996.0138 }}
| citations =
* {{cite journal | vauthors = Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA | title = Large-scale concatenation cDNA sequencing | journal = Genome Res. | volume = 7 | issue = 4 | pages = 353–8 | year = 1997 | pmid = 9110174 | pmc = 139146 | doi = 10.1101/gr.7.4.353 }}
*{{cite journal  | author=Kingsmore SF, Souryal CA, Watson ML, ''et al.'' |title=Physical and genetic linkage of the genes encoding Ly-9 and CD48 on mouse and human chromosomes 1. |journal=Immunogenetics |volume=42 |issue= 1 |pages= 59-62 |year= 1995 |pmid= 7797269 |doi=  }}
* {{cite journal | vauthors = Tovar V, de la Fuente MA, Pizcueta P, Bosch J, Engel P | title = Gene structure of the mouse leukocyte cell surface molecule Ly9 | journal = Immunogenetics | volume = 51 | issue = 10 | pages = 788–793 | year = 2000 | pmid = 10970093 | doi = 10.1007/s002510000209 }}
*{{cite journal  | author=Sandrin MS, Henning MM, Lo MF, ''et al.'' |title=Isolation and characterization of cDNA clones for Humly9: the human homologue of mouse Ly9. |journal=Immunogenetics |volume=43 |issue= 1-2 |pages= 13-9 |year= 1996 |pmid= 8537117 |doi=  }}
* {{cite journal | vauthors = de la Fuente MA, Tovar V, Villamor N, Zapater N, Pizcueta P, Campo E, Bosch J, Engel P | title = Molecular characterization and expression of a novel human leukocyte cell-surface marker homologous to mouse Ly-9 | journal = Blood | volume = 97 | issue = 11 | pages = 3513–3520 | year = 2001 | pmid = 11369645 | doi = 10.1182/blood.V97.11.3513 }}
*{{cite journal | author=Andersson B, Wentland MA, Ricafrente JY, ''et al.'' |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107-13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 }}
* {{cite journal | vauthors = Sayós J, Martín M, Chen A, Simarro M, Howie D, Morra M, Engel P, Terhorst C | title = Cell surface receptors Ly-9 and CD84 recruit the X-linked lymphoproliferative disease gene product SAP | journal = Blood | volume = 97 | issue = 12 | pages = 3867–3874 | year = 2001 | pmid = 11389028 | doi = 10.1182/blood.V97.12.3867 }}
*{{cite journal | author=Yu W, Andersson B, Worley KC, ''et al.'' |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353-8 |year= 1997 |pmid= 9110174 |doi= }}
* {{cite journal | vauthors = Morra M, Simarro-Grande M, Martin M, Chen AS, Lanyi A, Silander O, Calpe S, Davis J, Pawson T, Eck MJ, Sumegi J, Engel P, Li SC, Terhorst C | title = Characterization of SH2D1A missense mutations identified in X-linked lymphoproliferative disease patients | journal = J. Biol. Chem. | volume = 276 | issue = 39 | pages = 36809–36816 | year = 2001 | pmid = 11477068 | doi = 10.1074/jbc.M101305200 }}
*{{cite journal | author=Tovar V, de la Fuente MA, Pizcueta P, ''et al.'' |title=Gene structure of the mouse leukocyte cell surface molecule Ly9. |journal=Immunogenetics |volume=51 |issue= 10 |pages= 788-93 |year= 2000 |pmid= 10970093 |doi= }}
* {{cite journal | vauthors = Morra M, Lu J, Poy F, Martin M, Sayos J, Calpe S, Gullo C, Howie D, Rietdijk S, Thompson A, Coyle AJ, Denny C, Yaffe MB, Engel P, Eck MJ, Terhorst C | title = Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells | journal = EMBO J. | volume = 20 | issue = 21 | pages = 5840–5852 | year = 2001 | pmid = 11689425 | pmc = 125701 | doi = 10.1093/emboj/20.21.5840 }}
*{{cite journal | author=de la Fuente MA, Tovar V, Villamor N, ''et al.'' |title=Molecular characterization and expression of a novel human leukocyte cell-surface marker homologous to mouse Ly-9. |journal=Blood |volume=97 |issue= 11 |pages= 3513-20 |year= 2001 |pmid= 11369645 |doi= }}
* {{cite journal | vauthors = Tovar V, del Valle J, Zapater N, Martin M, Romero X, Pizcueta P, Bosch J, Terhorst C, Engel P | title = Mouse novel Ly9: a new member of the expanding CD150 (SLAM) family of leukocyte cell-surface receptors | journal = Immunogenetics | volume = 54 | issue = 6 | pages = 394–402 | year = 2002 | pmid = 12242590 | doi = 10.1007/s00251-002-0483-3 }}
*{{cite journal | author=Sayós J, Martín M, Chen A, ''et al.'' |title=Cell surface receptors Ly-9 and CD84 recruit the X-linked lymphoproliferative disease gene product SAP. |journal=Blood |volume=97 |issue= 12 |pages= 3867-74 |year= 2001 |pmid= 11389028 |doi= }}
* {{cite journal | vauthors = Del Valle JM, Engel P, Martín M | title = The cell surface expression of SAP-binding receptor CD229 is regulated via its interaction with clathrin-associated adaptor complex 2 (AP-2) | journal = J. Biol. Chem. | volume = 278 | issue = 19 | pages = 17430–17437 | year = 2003 | pmid = 12621057 | doi = 10.1074/jbc.M301569200 }}
*{{cite journal | author=Morra M, Simarro-Grande M, Martin M, ''et al.'' |title=Characterization of SH2D1A missense mutations identified in X-linked lymphoproliferative disease patients. |journal=J. Biol. Chem. |volume=276 |issue= 39 |pages= 36809-16 |year= 2001 |pmid= 11477068 |doi= 10.1074/jbc.M101305200 }}
* {{cite journal | vauthors = Martín M, Del Valle JM, Saborit I, Engel P | title = Identification of Grb2 as a novel binding partner of the signaling lymphocytic activation molecule-associated protein binding receptor CD229 | journal = J. Immunol. | volume = 174 | issue = 10 | pages = 5977–86 | year = 2005 | pmid = 15879090 | doi = 10.4049/jimmunol.174.10.5977 }}
*{{cite journal | author=Morra M, Lu J, Poy F, ''et al.'' |title=Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells. |journal=EMBO J. |volume=20 |issue= 21 |pages= 5840-52 |year= 2001 |pmid= 11689425 |doi= 10.1093/emboj/20.21.5840 }}
* {{cite journal | vauthors = Romero X, Zapater N, Calvo M, Kalko SG, de la Fuente MA, Tovar V, Ockeloen C, Pizcueta P, Engel P | title = CD229 (Ly9) lymphocyte cell surface receptor interacts homophilically through its N-terminal domain and relocalizes to the immunological synapse | journal = J. Immunol. | volume = 174 | issue = 11 | pages = 7033–42 | year = 2005 | pmid = 15905546 | doi = 10.4049/jimmunol.174.11.7033 }}
*{{cite journal | author=Tovar V, del Valle J, Zapater N, ''et al.'' |title=Mouse novel Ly9: a new member of the expanding CD150 (SLAM) family of leukocyte cell-surface receptors. |journal=Immunogenetics |volume=54 |issue= 6 |pages= 394-402 |year= 2002 |pmid= 12242590 |doi= 10.1007/s00251-002-0483-3 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Del Valle JM, Engel P, Martín M |title=The cell surface expression of SAP-binding receptor CD229 is regulated via its interaction with clathrin-associated adaptor complex 2 (AP-2). |journal=J. Biol. Chem. |volume=278 |issue= 19 |pages= 17430-7 |year= 2003 |pmid= 12621057 |doi= 10.1074/jbc.M301569200 }}
*{{cite journal | author=Martín M, Del Valle JM, Saborit I, Engel P |title=Identification of Grb2 as a novel binding partner of the signaling lymphocytic activation molecule-associated protein binding receptor CD229. |journal=J. Immunol. |volume=174 |issue= 10 |pages= 5977-86 |year= 2005 |pmid= 15879090 |doi= }}
*{{cite journal | author=Romero X, Zapater N, Calvo M, ''et al.'' |title=CD229 (Ly9) lymphocyte cell surface receptor interacts homophilically through its N-terminal domain and relocalizes to the immunological synapse. |journal=J. Immunol. |volume=174 |issue= 11 |pages= 7033-42 |year= 2005 |pmid= 15905546 |doi= }}
*{{cite journal  | author=Gregory SG, Barlow KF, McLay KE, ''et al.'' |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315-21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
}}
{{refend}}
{{refend}}


==External links==
== External links ==
* {{MeshName|LY9+protein,+human}}
* {{MeshName|LY9+protein,+human}}


{{membrane-protein-stub}}
{{NLM content}}
{{NLM content}}
{{Clusters of differentiation}}
{{Clusters of differentiation}}
[[Category:Clusters of differentiation]]
[[Category:Clusters of differentiation]]
{{WikiDoc Sources}}
 
 
{{membrane-protein-stub}}

Latest revision as of 18:14, 2 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

T-lymphocyte surface antigen Ly-9 is a protein that in humans is encoded by the LY9 gene.[1][2][3] LY9 has also recently been designated CD229 (cluster of differentiation 229).

Interactions

LY9 has been shown to interact with SH2D1A.[4][5]

References

  1. ↑ Sandrin MS, Henning MM, Lo MF, Baker E, Sutherland GR, McKenzie IF (Feb 1996). "Isolation and characterization of cDNA clones for Humly9: the human homologue of mouse Ly9". Immunogenetics. 43 (1–2): 13–9. doi:10.1007/bf00186599. PMID 8537117.
  2. ↑ Kingsmore SF, Souryal CA, Watson ML, Patel DD, Seldin MF (Aug 1995). "Physical and genetic linkage of the genes encoding Ly-9 and CD48 on mouse and human chromosomes 1". Immunogenetics. 42 (1): 59–62. doi:10.1007/BF00164988. PMID 7797269.
  3. ↑ "Entrez Gene: LY9 lymphocyte antigen 9".
  4. ↑ Sayós J, Martín M, Chen A, Simarro M, Howie D, Morra M, Engel P, Terhorst C (Jun 2001). "Cell surface receptors Ly-9 and CD84 recruit the X-linked lymphoproliferative disease gene product SAP". Blood. 97 (12): 3867–3874. doi:10.1182/blood.V97.12.3867. PMID 11389028.
  5. ↑ Morra M, Simarro-Grande M, Martin M, Chen AS, Lanyi A, Silander O, Calpe S, Davis J, Pawson T, Eck MJ, Sumegi J, Engel P, Li SC, Terhorst C (Sep 2001). "Characterization of SH2D1A missense mutations identified in X-linked lymphoproliferative disease patients". J. Biol. Chem. 276 (39): 36809–36816. doi:10.1074/jbc.M101305200. PMID 11477068.

Further reading

  • Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–113. doi:10.1006/abio.1996.0138. PMID 8619474.
  • Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
  • Tovar V, de la Fuente MA, Pizcueta P, Bosch J, Engel P (2000). "Gene structure of the mouse leukocyte cell surface molecule Ly9". Immunogenetics. 51 (10): 788–793. doi:10.1007/s002510000209. PMID 10970093.
  • de la Fuente MA, Tovar V, Villamor N, Zapater N, Pizcueta P, Campo E, Bosch J, Engel P (2001). "Molecular characterization and expression of a novel human leukocyte cell-surface marker homologous to mouse Ly-9". Blood. 97 (11): 3513–3520. doi:10.1182/blood.V97.11.3513. PMID 11369645.
  • Sayós J, Martín M, Chen A, Simarro M, Howie D, Morra M, Engel P, Terhorst C (2001). "Cell surface receptors Ly-9 and CD84 recruit the X-linked lymphoproliferative disease gene product SAP". Blood. 97 (12): 3867–3874. doi:10.1182/blood.V97.12.3867. PMID 11389028.
  • Morra M, Simarro-Grande M, Martin M, Chen AS, Lanyi A, Silander O, Calpe S, Davis J, Pawson T, Eck MJ, Sumegi J, Engel P, Li SC, Terhorst C (2001). "Characterization of SH2D1A missense mutations identified in X-linked lymphoproliferative disease patients". J. Biol. Chem. 276 (39): 36809–36816. doi:10.1074/jbc.M101305200. PMID 11477068.
  • Morra M, Lu J, Poy F, Martin M, Sayos J, Calpe S, Gullo C, Howie D, Rietdijk S, Thompson A, Coyle AJ, Denny C, Yaffe MB, Engel P, Eck MJ, Terhorst C (2001). "Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells". EMBO J. 20 (21): 5840–5852. doi:10.1093/emboj/20.21.5840. PMC 125701. PMID 11689425.
  • Tovar V, del Valle J, Zapater N, Martin M, Romero X, Pizcueta P, Bosch J, Terhorst C, Engel P (2002). "Mouse novel Ly9: a new member of the expanding CD150 (SLAM) family of leukocyte cell-surface receptors". Immunogenetics. 54 (6): 394–402. doi:10.1007/s00251-002-0483-3. PMID 12242590.
  • Del Valle JM, Engel P, Martín M (2003). "The cell surface expression of SAP-binding receptor CD229 is regulated via its interaction with clathrin-associated adaptor complex 2 (AP-2)". J. Biol. Chem. 278 (19): 17430–17437. doi:10.1074/jbc.M301569200. PMID 12621057.
  • Martín M, Del Valle JM, Saborit I, Engel P (2005). "Identification of Grb2 as a novel binding partner of the signaling lymphocytic activation molecule-associated protein binding receptor CD229". J. Immunol. 174 (10): 5977–86. doi:10.4049/jimmunol.174.10.5977. PMID 15879090.
  • Romero X, Zapater N, Calvo M, Kalko SG, de la Fuente MA, Tovar V, Ockeloen C, Pizcueta P, Engel P (2005). "CD229 (Ly9) lymphocyte cell surface receptor interacts homophilically through its N-terminal domain and relocalizes to the immunological synapse". J. Immunol. 174 (11): 7033–42. doi:10.4049/jimmunol.174.11.7033. PMID 15905546.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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