LNX1: Difference between revisions

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Latest revision as of 16:25, 8 October 2017

E3 ubiquitin-protein ligase LNX is an enzyme that in humans is encoded by the LNX1 gene.^[1]^[2]^[3]

Interactions

LNX1 has been shown to interact with NAGK,^[4] NUMB^[2] and PAFAH1B3.^[4]

References

↑ Xie Y, Zhao W, Wang W, Zhao S, Tang R, Ying K, Zhou Z, Mao Y (Apr 2001). "Identification of a human LNX protein containing multiple PDZ domains". Biochemical Genetics. 39 (3–4): 117–26. doi:10.1023/A:1010269908398. PMID 11521506.
↑ ^2.0 ^2.1 Nie J, McGill MA, Dermer M, Dho SE, Wolting CD, McGlade CJ (Jan 2002). "LNX functions as a RING type E3 ubiquitin ligase that targets the cell fate determinant Numb for ubiquitin-dependent degradation". The EMBO Journal. 21 (1–2): 93–102. doi:10.1093/emboj/21.1.93. PMC 125803. PMID 11782429.
↑ "Entrez Gene: LNX1 ligand of numb-protein X 1".
↑ ^4.0 ^4.1 Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.

Dho SE, Jacob S, Wolting CD, French MB, Rohrschneider LR, McGlade CJ (Apr 1998). "The mammalian numb phosphotyrosine-binding domain. Characterization of binding specificity and identification of a novel PDZ domain-containing numb binding protein, LNX". The Journal of Biological Chemistry. 273 (15): 9179–87. doi:10.1074/jbc.273.15.9179. PMID 9535908.
Rice DS, Northcutt GM, Kurschner C (Nov 2001). "The Lnx family proteins function as molecular scaffolds for Numb family proteins". Molecular and Cellular Neurosciences. 18 (5): 525–40. doi:10.1006/mcne.2001.1024. PMID 11922143.
Sollerbrant K, Raschperger E, Mirza M, Engstrom U, Philipson L, Ljungdahl PO, Pettersson RF (Feb 2003). "The Coxsackievirus and adenovirus receptor (CAR) forms a complex with the PDZ domain-containing protein ligand-of-numb protein-X (LNX)". The Journal of Biological Chemistry. 278 (9): 7439–44. doi:10.1074/jbc.M205927200. PMID 12468544.
Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A (Oct 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Research. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Katoh M, Katoh M (Apr 2004). "Identification and characterization of PDZRN3 and PDZRN4 genes in silico". International Journal of Molecular Medicine. 13 (4): 607–13. doi:10.3892/ijmm.13.4.607. PMID 15010864.
Armbruester V, Sauter M, Roemer K, Best B, Hahn S, Nty A, Schmid A, Philipp S, Mueller A, Mueller-Lantzsch N (Oct 2004). "Np9 protein of human endogenous retrovirus K interacts with ligand of numb protein X". Journal of Virology. 78 (19): 10310–9. doi:10.1128/JVI.78.19.10310-10319.2004. PMC 516385. PMID 15367597.
Chen J, Xu J, Zhao W, Hu G, Cheng H, Kang Y, Xie Y, Lu Y (Nov 2005). "Characterization of human LNX, a novel ligand of Numb protein X that is downregulated in human gliomas". The International Journal of Biochemistry & Cell Biology. 37 (11): 2273–83. doi:10.1016/j.biocel.2005.02.028. PMID 16002321.
Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (May 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
Weiss A, Baumgartner M, Radziwill G, Dennler J, Moelling K (Oct 2007). "c-Src is a PDZ interaction partner and substrate of the E3 ubiquitin ligase Ligand-of-Numb protein X1". FEBS Letters. 581 (26): 5131–6. doi:10.1016/j.febslet.2007.09.062. PMID 17936276.

This article on a gene on human chromosome 4 is a stub. You can help Wikipedia by expanding it.

[pmid11521506-1] Xie Y, Zhao W, Wang W, Zhao S, Tang R, Ying K, Zhou Z, Mao Y (Apr 2001). "Identification of a human LNX protein containing multiple PDZ domains". Biochemical Genetics. 39 (3–4): 117–26. doi:10.1023/A:1010269908398. PMID 11521506.

[pmid11782429-2] 2.0 ^2.1 Nie J, McGill MA, Dermer M, Dho SE, Wolting CD, McGlade CJ (Jan 2002). "LNX functions as a RING type E3 ubiquitin ligase that targets the cell fate determinant Numb for ubiquitin-dependent degradation". The EMBO Journal. 21 (1–2): 93–102. doi:10.1093/emboj/21.1.93. PMC 125803. PMID 11782429.

[entrez-3] "Entrez Gene: LNX1 ligand of numb-protein X 1".

[pmid16189514-4] 4.0 ^4.1 Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.

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[2]

[3]

[4]

@@ Line 1: / Line 1: @@
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
-{{PBB_Controls
+'''E3 ubiquitin-protein ligase LNX''' is an [[enzyme]] that in humans is encoded by the ''LNX1'' [[gene]].<ref name="pmid11521506">{{cite journal | vauthors = Xie Y, Zhao W, Wang W, Zhao S, Tang R, Ying K, Zhou Z, Mao Y | title = Identification of a human LNX protein containing multiple PDZ domains | journal = Biochemical Genetics | volume = 39 | issue = 3-4 | pages = 117–26 | date = Apr 2001 | pmid = 11521506 | pmc =  | doi = 10.1023/A:1010269908398 }}</ref><ref name="pmid11782429">{{cite journal | vauthors = Nie J, McGill MA, Dermer M, Dho SE, Wolting CD, McGlade CJ | title = LNX functions as a RING type E3 ubiquitin ligase that targets the cell fate determinant Numb for ubiquitin-dependent degradation | journal = The EMBO Journal | volume = 21 | issue = 1-2 | pages = 93–102 | date = Jan 2002 | pmid = 11782429 | pmc = 125803 | doi = 10.1093/emboj/21.1.93 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: LNX1 ligand of numb-protein X 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84708| accessdate = }}</ref>
-| update_page = yes
-| require_manual_inspection = no
-| update_protein_box = yes
-| update_summary = yes
-| update_citations = yes
-}}
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+== Interactions ==
-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = Ligand of numb-protein X 1
- | HGNCid = 6657
- | Symbol = LNX1
- | AltSymbols =; MPDZ; LNX; PDZRN2
- | OMIM = 609732
- | ECnumber =
- | Homologene = 7819
- | MGIid = 1278335
- | Function = {{GNF_GO|id=GO:0004842 |text = ubiquitin-protein ligase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016874 |text = ligase activity}} {{GNF_GO|id=GO:0030165 |text = PDZ domain binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
- | Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
- | Process = {{GNF_GO|id=GO:0006512 |text = ubiquitin cycle}} {{GNF_GO|id=GO:0042787 |text = protein ubiquitination during ubiquitin-dependent protein catabolic process}} {{GNF_GO|id=GO:0051260 |text = protein homooligomerization}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 84708
-    | Hs_Ensembl = ENSG00000072201
-    | Hs_RefseqProtein = NP_116011
-    | Hs_RefseqmRNA = NM_032622
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 4
-    | Hs_GenLoc_start = 54020225
-    | Hs_GenLoc_end = 54152481
-    | Hs_Uniprot = Q8TBB1
-    | Mm_EntrezGene = 16924
-    | Mm_Ensembl = ENSMUSG00000029228
-    | Mm_RefseqmRNA = NM_010727
-    | Mm_RefseqProtein = NP_034857
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 5
-    | Mm_GenLoc_start = 74874144
-    | Mm_GenLoc_end = 74984593
-    | Mm_Uniprot = O70263
-  }}
-}}
-'''Ligand of numb-protein X 1''', also known as '''LNX1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: LNX1 ligand of numb-protein X 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84708| accessdate = }}</ref>
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+LNX1 has been shown to [[Protein-protein interaction|interact]] with [[N-acetyl-D-glucosamine kinase|NAGK]],<ref name=pmid16189514>{{cite journal|authorlink30=Huda Zoghbi | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}</ref> [[NUMB (gene)|NUMB]]<ref name=pmid11782429 /> and [[PAFAH1B3]].<ref name=pmid16189514/>
-{{PBB_Summary
-| section_title =
-| summary_text =
-}}
-==References==
+== References ==
-{{reflist|2}}
+{{reflist}}
-==Further reading==
+== Further reading ==
 {{refbegin | 2}}
-{{PBB_Further_reading
+* {{cite journal | vauthors = Dho SE, Jacob S, Wolting CD, French MB, Rohrschneider LR, McGlade CJ | title = The mammalian numb phosphotyrosine-binding domain. Characterization of binding specificity and identification of a novel PDZ domain-containing numb binding protein, LNX | journal = The Journal of Biological Chemistry | volume = 273 | issue = 15 | pages = 9179–87 | date = Apr 1998 | pmid = 9535908 | doi = 10.1074/jbc.273.15.9179 }}
-| citations =
+* {{cite journal | vauthors = Rice DS, Northcutt GM, Kurschner C | title = The Lnx family proteins function as molecular scaffolds for Numb family proteins | journal = Molecular and Cellular Neurosciences | volume = 18 | issue = 5 | pages = 525–40 | date = Nov 2001 | pmid = 11922143 | doi = 10.1006/mcne.2001.1024 }}
-*{{cite journal  | author=Dho SE, Jacob S, Wolting CD, ''et al.'' |title=The mammalian numb phosphotyrosine-binding domain. Characterization of binding specificity and identification of a novel PDZ domain-containing numb binding protein, LNX. |journal=J. Biol. Chem. |volume=273 |issue= 15 |pages= 9179-87 |year= 1998 |pmid= 9535908 |doi=  }}
+* {{cite journal | vauthors = Sollerbrant K, Raschperger E, Mirza M, Engstrom U, Philipson L, Ljungdahl PO, Pettersson RF | title = The Coxsackievirus and adenovirus receptor (CAR) forms a complex with the PDZ domain-containing protein ligand-of-numb protein-X (LNX) | journal = The Journal of Biological Chemistry | volume = 278 | issue = 9 | pages = 7439–44 | date = Feb 2003 | pmid = 12468544 | doi = 10.1074/jbc.M205927200 }}
-*{{cite journal  | author=Xie Y, Zhao W, Wang W, ''et al.'' |title=Identification of a human LNX protein containing multiple PDZ domains. |journal=Biochem. Genet. |volume=39 |issue= 3-4 |pages= 117-26 |year= 2002 |pmid= 11521506 |doi=  }}
+* {{cite journal | vauthors = Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A | title = The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment | journal = Genome Research | volume = 13 | issue = 10 | pages = 2265–70 | date = Oct 2003 | pmid = 12975309 | pmc = 403697 | doi = 10.1101/gr.1293003 }}
-*{{cite journal  | author=Nie J, McGill MA, Dermer M, ''et al.'' |title=LNX functions as a RING type E3 ubiquitin ligase that targets the cell fate determinant Numb for ubiquitin-dependent degradation. |journal=EMBO J. |volume=21 |issue= 1-2 |pages= 93-102 |year= 2002 |pmid= 11782429 |doi= 10.1093/emboj/21.1.93 }}
+* {{cite journal | vauthors = Katoh M, Katoh M | title = Identification and characterization of PDZRN3 and PDZRN4 genes in silico | journal = International Journal of Molecular Medicine | volume = 13 | issue = 4 | pages = 607–13 | date = Apr 2004 | pmid = 15010864 | doi = 10.3892/ijmm.13.4.607 }}
-*{{cite journal  | author=Rice DS, Northcutt GM, Kurschner C |title=The Lnx family proteins function as molecular scaffolds for Numb family proteins. |journal=Mol. Cell. Neurosci. |volume=18 |issue= 5 |pages= 525-40 |year= 2002 |pmid= 11922143 |doi= 10.1006/mcne.2001.1024 }}
+* {{cite journal | vauthors = Armbruester V, Sauter M, Roemer K, Best B, Hahn S, Nty A, Schmid A, Philipp S, Mueller A, Mueller-Lantzsch N | title = Np9 protein of human endogenous retrovirus K interacts with ligand of numb protein X | journal = Journal of Virology | volume = 78 | issue = 19 | pages = 10310–9 | date = Oct 2004 | pmid = 15367597 | pmc = 516385 | doi = 10.1128/JVI.78.19.10310-10319.2004 }}
-*{{cite journal  | author=Sollerbrant K, Raschperger E, Mirza M, ''et al.'' |title=The Coxsackievirus and adenovirus receptor (CAR) forms a complex with the PDZ domain-containing protein ligand-of-numb protein-X (LNX). |journal=J. Biol. Chem. |volume=278 |issue= 9 |pages= 7439-44 |year= 2003 |pmid= 12468544 |doi= 10.1074/jbc.M205927200 }}
+* {{cite journal | vauthors = Chen J, Xu J, Zhao W, Hu G, Cheng H, Kang Y, Xie Y, Lu Y | title = Characterization of human LNX, a novel ligand of Numb protein X that is downregulated in human gliomas | journal = The International Journal of Biochemistry & Cell Biology | volume = 37 | issue = 11 | pages = 2273–83 | date = Nov 2005 | pmid = 16002321 | doi = 10.1016/j.biocel.2005.02.028 }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+* {{cite journal | vauthors = Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY | title = A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration | journal = Cell | volume = 125 | issue = 4 | pages = 801–14 | date = May 2006 | pmid = 16713569 | doi = 10.1016/j.cell.2006.03.032 }}
-*{{cite journal  | author=Clark HF, Gurney AL, Abaya E, ''et al.'' |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265-70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 }}
+* {{cite journal | vauthors = Weiss A, Baumgartner M, Radziwill G, Dennler J, Moelling K | title = c-Src is a PDZ interaction partner and substrate of the E3 ubiquitin ligase Ligand-of-Numb protein X1 | journal = FEBS Letters | volume = 581 | issue = 26 | pages = 5131–6 | date = Oct 2007 | pmid = 17936276 | doi = 10.1016/j.febslet.2007.09.062 }}
-*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
-*{{cite journal  | author=Katoh M, Katoh M |title=Identification and characterization of PDZRN3 and PDZRN4 genes in silico. |journal=Int. J. Mol. Med. |volume=13 |issue= 4 |pages= 607-13 |year= 2004 |pmid= 15010864 |doi=  }}
-*{{cite journal  | author=Armbruester V, Sauter M, Roemer K, ''et al.'' |title=Np9 protein of human endogenous retrovirus K interacts with ligand of numb protein X. |journal=J. Virol. |volume=78 |issue= 19 |pages= 10310-9 |year= 2004 |pmid= 15367597 |doi= 10.1128/JVI.78.19.10310-10319.2004 }}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
-*{{cite journal  | author=Chen J, Xu J, Zhao W, ''et al.'' |title=Characterization of human LNX, a novel ligand of Numb protein X that is downregulated in human gliomas. |journal=Int. J. Biochem. Cell Biol. |volume=37 |issue= 11 |pages= 2273-83 |year= 2005 |pmid= 16002321 |doi= 10.1016/j.biocel.2005.02.028 }}
-*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
-*{{cite journal  | author=Lim J, Hao T, Shaw C, ''et al.'' |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801-14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 }}
-*{{cite journal  | author=Weiss A, Baumgartner M, Radziwill G, ''et al.'' |title=c-Src is a PDZ interaction partner and substrate of the E3 ubiquitin ligase Ligand-of-Numb protein X1. |journal=FEBS Lett. |volume=581 |issue= 26 |pages= 5131-6 |year= 2007 |pmid= 17936276 |doi= 10.1016/j.febslet.2007.09.062 }}
-}}
 {{refend}}
-{{protein-stub}}
+{{gene-4-stub}}
-{{WikiDoc Sources}}

LNX1: Difference between revisions

Latest revision as of 16:25, 8 October 2017

Interactions

References

Further reading

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