View source for LMTK2

{{Infobox_gene}}
'''Serine/threonine-protein kinase LMTK2''' also known as '''Lemur tyrosine kinase 2''' (LMTK2) is an [[enzyme]] that in humans is encoded by the ''LMTK2'' [[gene]].<ref name="pmid15005709">{{cite journal | vauthors = Kawa S, Fujimoto J, Tezuka T, Nakazawa T, Yamamoto T | title = Involvement of BREK, a serine/threonine kinase enriched in brain, in NGF signalling | journal = Genes to Cells | volume = 9 | issue = 3 | pages = 219–32 | date = Mar 2004 | pmid = 15005709 | pmc =  | doi = 10.1111/j.1356-9597.2004.00714.x }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: LMTK2 lemur tyrosine kinase 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22853| accessdate = }}</ref>

== Function ==

The LMTK2 enzyme belongs to both the [[protein kinase]] and the [[tyrosine kinase]] families. It contains [[N-terminal|N-terminus]] transmembrane helices and a long [[C-terminus|C-terminal]] cytoplasmic tail with serine/threonine/tyrosine kinase activity.  This protein interacts with several other proteins, such as androgen receptor, inhibitor-2 (Inh2), protein phosphatase-1 ([[PPP1CA|PP1C]]), [[CDK5R1|p35]], and [[myosin|myosin VI]]. It [[Phosphorylation|phosphorylates]] other proteins, and is itself also phosphorylated when interacting with cyclin-dependent kinase 5 ([[cyclin-dependent kinase 5|cdk5]])/[[CDK5R1|p35]] complex. This protein is involved in nerve growth factor ([[nerve growth factor|NGF]])-[[TrkA receptor|TrkA]] signalling, and also plays a critical role in [[endosome|endosomal]] membrane [[Protein targeting|trafficking]]. Mouse studies suggested an essential role of this protein in [[spermatogenesis]].<ref name="entrez"/>

== Clinical significance ==

Loss of LMTK2 has been implicated to play a role in development of [[prostate cancer]].<ref>{{cite journal | vauthors = Shah K, Bradbury NA | title = Lemur Tyrosine Kinase 2, a novel target in prostate cancer therapy | journal = Oncotarget | volume = 6 | issue = 16 | pages = 14233–46 | date = Jun 2015 | pmid = 26008968 | url = http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path[]=3899 | doi=10.18632/oncotarget.3899 | pmc=4546463}}</ref>

== Interactions ==

LMTK2 has been shown to [[Protein-protein interaction|interact]] with [[PPP1CA]],<ref name=pmid12393858>{{cite journal | vauthors = Wang H, Brautigan DL | title = A novel transmembrane Ser/Thr kinase complexes with protein phosphatase-1 and inhibitor-2 | journal = The Journal of Biological Chemistry | volume = 277 | issue = 51 | pages = 49605–12 | date = Dec 2002 | pmid = 12393858 | doi = 10.1074/jbc.M209335200 }}</ref> [[Cyclin-dependent kinase 5]]<ref name=pmid12832520>{{cite journal | vauthors = Kesavapany S, Lau KF, Ackerley S, Banner SJ, Shemilt SJ, Cooper JD, Leigh PN, Shaw CE, McLoughlin DM, Miller CC | title = Identification of a novel, membrane-associated neuronal kinase, cyclin-dependent kinase 5/p35-regulated kinase | journal = The Journal of Neuroscience | volume = 23 | issue = 12 | pages = 4975–83 | date = Jun 2003 | pmid = 12832520 }}</ref> and [[PPP1R2]].<ref name=pmid12393858/>

== References ==
{{reflist}}

== Further reading ==
{{refbegin | 2}}
* {{cite journal | vauthors = Eeles RA, Kote-Jarai Z, Giles GG, Olama AA, Guy M, Jugurnauth SK, Mulholland S, Leongamornlert DA, Edwards SM, Morrison J, Field HI, Southey MC, Severi G, Donovan JL, Hamdy FC, Dearnaley DP, Muir KR, Smith C, Bagnato M, Ardern-Jones AT, Hall AL, O'Brien LT, Gehr-Swain BN, Wilkinson RA, Cox A, Lewis S, Brown PM, Jhavar SG, Tymrakiewicz M, Lophatananon A, Bryant SL, Horwich A, Huddart RA, Khoo VS, Parker CC, Woodhouse CJ, Thompson A, Christmas T, Ogden C, Fisher C, Jamieson C, Cooper CS, English DR, Hopper JL, Neal DE, Easton DF | title = Multiple newly identified loci associated with prostate cancer susceptibility | journal = Nature Genetics | volume = 40 | issue = 3 | pages = 316–21 | date = Mar 2008 | pmid = 18264097 | doi = 10.1038/ng.90 }}
* {{cite journal | vauthors = Chibalina MV, Seaman MN, Miller CC, Kendrick-Jones J, Buss F | title = Myosin VI and its interacting protein LMTK2 regulate tubule formation and transport to the endocytic recycling compartment | journal = Journal of Cell Science | volume = 120 | issue = Pt 24 | pages = 4278–88 | date = Dec 2007 | pmid = 18029400 | pmc = 2621362 | doi = 10.1242/jcs.014217 }}
* {{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | date = Nov 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 }}
* {{cite journal | vauthors = Wang H, Brautigan DL | title = Peptide microarray analysis of substrate specificity of the transmembrane Ser/Thr kinase KPI-2 reveals reactivity with cystic fibrosis transmembrane conductance regulator and phosphorylase | journal = Molecular & Cellular Proteomics | volume = 5 | issue = 11 | pages = 2124–30 | date = Nov 2006 | pmid = 16887929 | doi = 10.1074/mcp.M600188-MCP200 }}
* {{cite journal | vauthors = Kesavapany S, Lau KF, Ackerley S, Banner SJ, Shemilt SJ, Cooper JD, Leigh PN, Shaw CE, McLoughlin DM, Miller CC | title = Identification of a novel, membrane-associated neuronal kinase, cyclin-dependent kinase 5/p35-regulated kinase | journal = The Journal of Neuroscience | volume = 23 | issue = 12 | pages = 4975–83 | date = Jun 2003 | pmid = 12832520 | doi =  }}
* {{cite journal | vauthors = Wang H, Brautigan DL | title = A novel transmembrane Ser/Thr kinase complexes with protein phosphatase-1 and inhibitor-2 | journal = The Journal of Biological Chemistry | volume = 277 | issue = 51 | pages = 49605–12 | date = Dec 2002 | pmid = 12393858 | doi = 10.1074/jbc.M209335200 }}
* {{cite journal | vauthors = Kikuno R, Nagase T, Ishikawa K, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Research | volume = 6 | issue = 3 | pages = 197–205 | date = Jun 1999 | pmid = 10470851 | doi = 10.1093/dnares/6.3.197 }}
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{{NLM content}}

{{Tyrosine kinases}}


{{gene-7-stub}}