LAMP2
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Lysosomal-associated membrane protein 2 (LAMP2) also known as CD107b (Cluster of Differentiation 107b), is a human gene.
The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may play a role in tumor cell metastasis. It may also function in the protection, maintenance, and adhesion of the lysosome. Alternative splicing of the gene produces two known products of unknown function. [1] Recently it has been determined that antibodies against LAMP-2 account for a fraction of patients who get a serious kidney disease termed focal necrotizing glomerulonephritis.
Related Chapters
References
Further reading
- Chang MH, Karageorgos LE, Meikle PJ (2003). "CD107a (LAMP-1) and CD107b (LAMP-2)". J. Biol. Regul. Homeost. Agents. 16 (2): 147–51. PMID 12144129.
- Schleutker J, Haataja L, Renlund M; et al. (1992). "Confirmation of the chromosomal localization of human lamp genes and their exclusion as candidate genes for Salla disease". Hum. Genet. 88 (1): 95–7. PMID 1959930.
- Manoni M, Tribioli C, Lazzari B; et al. (1991). "The nucleotide sequence of a CpG island demonstrates the presence of the first exon of the gene encoding the human lysosomal membrane protein lamp2 and assigns the gene to Xq24". Genomics. 9 (3): 551–4. PMID 2032724.
- Carlsson SR, Fukuda M (1990). "The polylactosaminoglycans of human lysosomal membrane glycoproteins lamp-1 and lamp-2. Localization on the peptide backbones". J. Biol. Chem. 265 (33): 20488–95. PMID 2243102.
- Mattei MG, Matterson J, Chen JW; et al. (1990). "Two human lysosomal membrane glycoproteins, h-lamp-1 and h-lamp-2, are encoded by genes localized to chromosome 13q34 and chromosome Xq24-25, respectively". J. Biol. Chem. 265 (13): 7548–51. PMID 2332441.
- Mane SM, Marzella L, Bainton DF; et al. (1989). "Purification and characterization of human lysosomal membrane glycoproteins". Arch. Biochem. Biophys. 268 (1): 360–78. PMID 2912382.
- Fukuda M, Viitala J, Matteson J, Carlsson SR (1989). "Cloning of cDNAs encoding human lysosomal membrane glycoproteins, h-lamp-1 and h-lamp-2. Comparison of their deduced amino acid sequences". J. Biol. Chem. 263 (35): 18920–8. PMID 3198605.
- Dahlgren C, Carlsson SR, Karlsson A; et al. (1995). "The lysosomal membrane glycoproteins Lamp-1 and Lamp-2 are present in mobilizable organelles, but are absent from the azurophil granules of human neutrophils". Biochem. J. 311 ( Pt 2): 667–74. PMID 7487911.
- Konecki DS, Foetisch K, Zimmer KP; et al. (1995). "An alternatively spliced form of the human lysosome-associated membrane protein-2 gene is expressed in a tissue-specific manner". Biochem. Biophys. Res. Commun. 215 (2): 757–67. PMID 7488019.
- Konecki DS, Foetisch K, Schlotter M, Lichter-Konecki U (1995). "Complete cDNA sequence of human lysosome-associated membrane protein-2". Biochem. Biophys. Res. Commun. 205 (1): 1–5. PMID 7999007.
- Carlsson SR, Lycksell PO, Fukuda M (1993). "Assignment of O-glycan attachment sites to the hinge-like regions of human lysosomal membrane glycoproteins lamp-1 and lamp-2". Arch. Biochem. Biophys. 304 (1): 65–73. doi:10.1006/abbi.1993.1322. PMID 8323299.
- Sawada R, Jardine KA, Fukuda M (1993). "The genes of major lysosomal membrane glycoproteins, lamp-1 and lamp-2. 5'-flanking sequence of lamp-2 gene and comparison of exon organization in two genes". J. Biol. Chem. 268 (12): 9014–22. PMID 8517882.
- Kannan K, Stewart RM, Bounds W; et al. (1996). "Lysosome-associated membrane proteins h-LAMP1 (CD107a) and h-LAMP2 (CD107b) are activation-dependent cell surface glycoproteins in human peripheral blood mononuclear cells which mediate cell adhesion to vascular endothelium". Cell. Immunol. 171 (1): 10–9. doi:10.1006/cimm.1996.0167. PMID 8660832.
- Israels SJ, McMillan EM, Robertson C; et al. (1996). "The lysosomal granule membrane protein, LAMP-2, is also present in platelet dense granule membranes". Thromb. Haemost. 75 (4): 623–9. PMID 8743190.
- Aumüller G, Renneberg H, Hasilik A (1997). "Distribution and subcellular localization of a lysosome-associated protein in human genital organs". Cell Tissue Res. 287 (2): 335–42. PMID 8995204.
- Akasaki K, Michihara A, Fujiwara Y; et al. (1997). "Biosynthetic transport of a major lysosome-associated membrane glycoprotein 2, lamp-2: a significant fraction of newly synthesized lamp-2 is delivered to lysosomes by way of early endosomes". J. Biochem. 120 (6): 1088–94. PMID 9010755.
- Karlsson K, Carlsson SR (1998). "Sorting of lysosomal membrane glycoproteins lamp-1 and lamp-2 into vesicles distinct from mannose 6-phosphate receptor/gamma-adaptin vesicles at the trans-Golgi network". J. Biol. Chem. 273 (30): 18966–73. PMID 9668075.
- Ayala P, Lin L, Hopper S; et al. (1998). "Infection of epithelial cells by pathogenic neisseriae reduces the levels of multiple lysosomal constituents". Infect. Immun. 66 (10): 5001–7. PMID 9746610.
- Furuta K, Yang XL, Chen JS; et al. (1999). "Differential expression of the lysosome-associated membrane proteins in normal human tissues". Arch. Biochem. Biophys. 365 (1): 75–82. doi:10.1006/abbi.1999.1147. PMID 10222041.
- Nishino I, Fu J, Tanji K; et al. (2000). "Primary LAMP-2 deficiency causes X-linked vacuolar cardiomyopathy and myopathy (Danon disease)". Nature. 406 (6798): 906–10. doi:10.1038/35022604. PMID 10972294.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.