View source for L1TD1

{{Infobox_gene}}
'''LINE-1 type transposase domain containing 1''', also known as '''L1TD1''', is an [[RNA-binding protein]] that involved with self-renewal of undifferentiated human [[embryonic stem cell]]s and [[cancer cell]] proliferation.  L1TD1 has been reported to associate with the development of several [[cancer]]s.
<ref name="pmid21637830">
{{
cite journal |vauthors=Iwabuchi KA, Yamakawa T, Sato Y, Ichisaka T, Takahashi K, Okita K, Yamanaka S | 
title = ECAT11/L1td1 is enriched in ESCs and rapidly activated during iPSC generation, but it is dispensable for the maintenance and induction of pluripotency | 
journal = PLOS ONE | 
volume = 6 | 
issue = 5 | 
pages = e20461 |date=May 2011 | 
pmid = 21637830 | 
doi = 10.1371/journal.pone.0020461 | 
url = http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0020461 | 
issn =
 | pmc=3102727
}}</ref>
<ref name="pmid22162396">
{{
cite journal |vauthors=Närvä E, Rahkonen N, Emani MR, Lund R, Pursiheimo JP, Nästi J, Autio R, Rasool O, Denessiouk K, Lähdesmäki H, Rao A, Lahesmaa R | 
title = RNA-binding protein L1TD1 interacts with LIN28 via RNA and is required for human embryonic stem cell self-renewal and cancer cell proliferation | 
journal = Stem Cells | 
volume = 30 | 
issue = 3 | 
pages = 452–60 |date=March 2012 | 
pmid = 22162396 | 
doi = 10.1002/stem.1013 | 
url = | 
issn =
 | pmc=3507993
}}</ref>
<ref name="pmid21559406">
{{
cite journal |vauthors=Wong RC, Ibrahim A, Fong H, Thompson N, Lock LF, Donovan PJ | 
title = L1TD1 is a marker for undifferentiated human embryonic stem cells | 
journal = PLOS ONE | 
volume = 6 | 
issue = 4 | 
pages = e19355 |date=April 2011 | 
pmid = 21559406 | 
doi = 10.1371/journal.pone.0019355 | 
issn =
 | pmc=3084827
}}</ref>
<ref name="pmid18842996">
{{
cite journal |vauthors=Yamamoto E, Toyota M, Suzuki H, Kondo Y, Sanomura T, Murayama Y, Ohe-Toyota M, Maruyama R, Nojima M, Ashida M, Fujii K, Sasaki Y, Hayashi N, Mori M, Imai K, Tokino T, Shinomura Y | 
title = LINE-1 hypomethylation is associated with increased CpG island methylation in Helicobacter pylori-related enlarged-fold gastritis | 
journal = Cancer Epidemiol Biomarkers Prev | 
volume = 17 | 
issue = 10 | 
pages = 2555–64 |date=October 2008 | 
pmid = 18842996 | 
doi = 10.1158/1055-9965.EPI-08-0112| 
url = http://cebp.aacrjournals.org/content/17/10/2555.long | 
issn = 
}}</ref>

==References==
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==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal   |vauthors=Mitsui  K, Tokuzawa  Y, Itoh  H, etal |title=The  homeoprotein  Nanog  isrequired  for  maintenance  of  pluripotency  in  mouse  epiblast  and  ES cells |journal=Cell |volume=113 |issue= 5 |pages= 631–42 |year= 2003 |pmid= 12787504 |url= http://www.sciencedirect.com/science/article/pii/S0092867403003933 |doi=10.1016/S0092-8674(03)00393-3}}
}}
*{{cite journal   |vauthors=Cash HL, Tao L, Yuan JM, etal |title=LINE-1 hypomethylation is associated with bladder cancer risk among nonsmoking Chinese |journal=Int J Cancer |volume=130 |issue= 5 |pages= 1151–9 |year= 2012 |pmid= 21445976 |doi = 10.1002/ijc.26098 |pmc=3208798}}
{{refend}}