L-selectin: Difference between revisions

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L-selectin, also known as CD62L, is a cell adhesion molecule found on lymphocytes and the preimplantation embryo. It belongs to the selectin family of proteins, which recognize sialylated carbohydrate groups. It is cleaved by ADAM17.

SELL is a cell surface component that is a member of a family of adhesion/homing receptors that play important roles in lymphocyte-endothelial cell interactions. The molecule is composed of multiple domains: one homologous to lectins, one to epidermal growth factor, and two to the consensus repeat units found in C3/C4-binding proteins.^[1]

Ligands

GlyCAM-1, found in the high endothelial venules of the lymph nodes.
CD34, found on endothelial cells.
MadCAM-1, found on endothelial cells of gut-associated lymphoid tissue.
PSGL-1, binds with low affinity.

Function

L-selectin acts as a "homing receptor" for lymphocytes to enter secondary lymphoid tissues via high endothelial venules. Ligands present on endothelial cells will bind to lymphocytes expressing L-selectin, slowing lymphocyte trafficking through the blood, and facilitating entry into a secondary lymphoid organ at that point.^[2] The receptor is commonly found on the cell surfaces of T cells. Naive T-lymphocytes, which have not yet encountered their specific antigen, need to enter secondary lymph nodes to encounter their antigen. Central memory T-lymphocytes, which have encountered antigen, express L-selectin to localize in secondary lymphoid organs. Here they reside ready to proliferate upon re-encountering antigen. Effector memory T-lymphocytes do not express L-selectin, as they circulate in the periphery and have immediate effector functions upon encountering antigen.

High expression of L-selectin on human bone marrow progenitor cells is an early sign of cells becoming committed to lymphoid differentiation.^[3]

L-selectin is also present on the surface of human embryo trophoblasts prior to implantation into the uterus. Similar to its function in lymphocytes, L-selectin acts as a receptor to facilitate adhesion of the embryo to the site of invasion on the surface epithelium of the uterine endometrium. The embryo secretes human chorionic gonadotropin (hCG), which downregulates anti-adhesion factor, MUC-1, located on the uterine epithelium at the site of invasion. Removal of MUC-1 exposes the oligosaccharide ligands of the uterine epithelium, thus allowing binding by the L-selectin receptor of the trophopblast cell, followed by embryo adhesion and invasion.^[4]

References

↑ "Entrez Gene: SELL selectin L (lymphocyte adhesion molecule 1)".
↑ Robbins SL, Cotran RS, Kumar V, Collins T (1998). Robbins Pathologic Basis of Disease. Philadelphia: W.B Saunders Company. ISBN 0-7216-7335-X.
↑ Kohn LA, Hao QL, Sasidharan R, Parekh C, Ge S, Zhu Y, Mikkola HK, Crooks GM (October 2012). "Lymphoid priming in human bone marrow begins before expression of CD10 with upregulation of L-selectin". Nat. Immunol. 13 (10): 963–71. doi:10.1038/ni.2405. PMID 22941246.
↑ James JL, Carter AM, Chamley LW (May 2012). "Human placentation from nidation to 5 weeks of gestation. Part I: What do we know about formative placental development following implantation?". Placenta. 33 (5): 327–34. doi:10.1016/j.placenta.2012.01.020. PMID 22374510.

External links

L-Selectin at the US National Library of Medicine Medical Subject Headings (MeSH)
Immunology at MCG 1/physresp

Ryan US, Worthington RE (1992). "Cell-cell contact mechanisms". Curr. Opin. Immunol. 4 (1): 33–7. doi:10.1016/0952-7915(92)90120-4. PMID 1375831.
Nicholson IC (2003). "CD62L (L-selectin)". J. Biol. Regul. Homeost. Agents. 16 (2): 144–6. PMID 12144128.
Ivetic A, Ridley AJ (2005). "The telling tail of L-selectin". Biochem. Soc. Trans. 32 (Pt 6): 1118–21. doi:10.1042/BST0321118. PMID 15506984.
Lasky LA, Singer MS, Dowbenko D, et al. (1992). "An endothelial ligand for L-selectin is a novel mucin-like molecule". Cell. 69 (6): 927–38. doi:10.1016/0092-8674(92)90612-G. PMID 1376638.
Ord DC, Ernst TJ, Zhou LJ, et al. (1990). "Structure of the gene encoding the human leukocyte adhesion molecule-1 (TQ1, Leu-8) of lymphocytes and neutrophils". J. Biol. Chem. 265 (14): 7760–7. PMID 1692315.
Bevilacqua M, Butcher E, Furie B, et al. (1991). "Selectins: a family of adhesion receptors". Cell. 67 (2): 233. doi:10.1016/0092-8674(91)90174-W. PMID 1717161.
Tedder TF, Isaacs CM, Ernst TJ, et al. (1989). "Isolation and chromosomal localization of cDNAs encoding a novel human lymphocyte cell surface molecule, LAM-1. Homology with the mouse lymphocyte homing receptor and other human adhesion proteins". J. Exp. Med. 170 (1): 123–33. doi:10.1084/jem.170.1.123. PMC 2189363. PMID 2473156.
Camerini D, James SP, Stamenkovic I, Seed B (1989). "Leu-8/TQ1 is the human equivalent of the Mel-14 lymph node homing receptor". Nature. 342 (6245): 78–82. doi:10.1038/342078a0. PMID 2509939.
Bowen BR, Nguyen T, Lasky LA (1989). "Characterization of a human homologue of the murine peripheral lymph node homing receptor". J. Cell Biol. 109 (1): 421–7. doi:10.1083/jcb.109.1.421. PMC 2115458. PMID 2663882.
Siegelman MH, Weissman IL (1989). "Human homologue of mouse lymph node homing receptor: evolutionary conservation at tandem cell interaction domains". Proc. Natl. Acad. Sci. U.S.A. 86 (14): 5562–6. doi:10.1073/pnas.86.14.5562. PMC 336895. PMID 2664786.
Bajorath J, Aruffo A (1995). "A template for generation and comparison of three-dimensional selectin models". Biochem. Biophys. Res. Commun. 216 (3): 1018–23. doi:10.1006/bbrc.1995.2722. PMID 7488174.
Dianzani U, Bragardo M, Buonfiglio D, et al. (1995). "Modulation of CD4 lateral interaction with lymphocyte surface molecules induced by HIV-1 gp120". Eur. J. Immunol. 25 (5): 1306–11. doi:10.1002/eji.1830250526. PMID 7539755.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Brenner B, Gulbins E, Schlottmann K, et al. (1997). "L-selectin activates the Ras pathway via the tyrosine kinase p56lck". Proc. Natl. Acad. Sci. U.S.A. 93 (26): 15376–81. doi:10.1073/pnas.93.26.15376. PMC 26412. PMID 8986819.
Zöllner O, Lenter MC, Blanks JE, et al. (1997). "L-selectin from human, but not from mouse neutrophils binds directly to E-selectin". J. Cell Biol. 136 (3): 707–16. doi:10.1083/jcb.136.3.707. PMC 2134294. PMID 9024699.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Prakobphol A, Thomsson KA, Hansson GC, et al. (1998). "Human low-molecular-weight salivary mucin expresses the sialyl lewisx determinant and has L-selectin ligand activity". Biochemistry. 37 (14): 4916–27. doi:10.1021/bi972612a. PMID 9538010.
Sassetti C, Tangemann K, Singer MS, et al. (1998). "Identification of podocalyxin-like protein as a high endothelial venule ligand for L-selectin: parallels to CD34". J. Exp. Med. 187 (12): 1965–75. doi:10.1084/jem.187.12.1965. PMC 2212365. PMID 9625756.
Malhotra R, Ward M, Sim RB, Bird MI (1999). "Identification of human complement Factor H as a ligand for L-selectin". Biochem. J. 341 (1): 61–9. doi:10.1042/0264-6021:3410061. PMC 1220330. PMID 10377245.
Bradley LM, Duncan DD, Tonkonogy S, Swain SL (1999). "CD4+ effector T cells in vivo: immunization results in a transient population of MEL-14-, CD45RB- helper cells that secretes interleukin 2 (IL-2), IL-3, IL-4, and interferon gamma". J. Exp. Med. 174 (3): 547–59. doi:10.1084/jem.174.3.547. PMC 2118927. PMID 1678774.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[1] "Entrez Gene: SELL selectin L (lymphocyte adhesion molecule 1)".

[robspath-2] Robbins SL, Cotran RS, Kumar V, Collins T (1998). Robbins Pathologic Basis of Disease. Philadelphia: W.B Saunders Company. ISBN 0-7216-7335-X.

[pmid22941246-3] Kohn LA, Hao QL, Sasidharan R, Parekh C, Ge S, Zhu Y, Mikkola HK, Crooks GM (October 2012). "Lymphoid priming in human bone marrow begins before expression of CD10 with upregulation of L-selectin". Nat. Immunol. 13 (10): 963–71. doi:10.1038/ni.2405. PMID 22941246.

[pmid22374510-4] James JL, Carter AM, Chamley LW (May 2012). "Human placentation from nidation to 5 weeks of gestation. Part I: What do we know about formative placental development following implantation?". Placenta. 33 (5): 327–34. doi:10.1016/j.placenta.2012.01.020. PMID 22374510.

[1]

[2]

[3]

[4]

@@ Line 1: / Line 1: @@
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+{{Infobox_gene}}
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-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+'''L-selectin''', also known as '''CD62L''', is a [[cell adhesion molecule]] found on [[lymphocytes]] and the preimplantation embryo. It belongs to the [[selectin]] family of proteins, which recognize sialylated carbohydrate groups. It is cleaved by [[ADAM17]].
-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = Selectin L (lymphocyte adhesion molecule 1)
- | HGNCid = 10720
- | Symbol = SELL
- | AltSymbols =; CD62L; LAM-1; LAM1; LECAM1; LNHR; LSEL; LYAM1; Leu-8; Lyam-1; PLNHR; TQ1; hLHRc
- | OMIM = 153240
- | ECnumber =
- | Homologene = 539
- | MGIid = 98279
- | GeneAtlas_image1 = PBB_GE_SELL_204563_at_tn.png
- | Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005529 |text = sugar binding}}
- | Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0009897 |text = external side of plasma membrane}}
- | Process = {{GNF_GO|id=GO:0006928 |text = cell motility}} {{GNF_GO|id=GO:0007155 |text = cell adhesion}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 6402
-    | Hs_Ensembl = ENSG00000188404
-    | Hs_RefseqProtein = NP_000646
-    | Hs_RefseqmRNA = NM_000655
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 1
-    | Hs_GenLoc_start = 167926432
-    | Hs_GenLoc_end = 167947463
-    | Hs_Uniprot = P14151
-    | Mm_EntrezGene = 20343
-    | Mm_Ensembl = ENSMUSG00000026581
-    | Mm_RefseqmRNA = NM_011346
-    | Mm_RefseqProtein = NP_035476
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 1
-    | Mm_GenLoc_start = 165899728
-    | Mm_GenLoc_end = 165909011
-    | Mm_Uniprot = Q3TA36
-  }}
-}}
-'''L-selectin''', also known as '''CD62L''', is a [[cell adhesion molecule]] found on [[leukocytes]]. It belongs to the [[selectin]] family of proteins, which recognise sialylated carbohydrate groups. It is cleaved by [[ADAM17]].
+SELL is a cell surface component that is a member of a family of adhesion/homing receptors that play important roles in lymphocyte-endothelial cell interactions. The molecule is composed of multiple domains: one homologous to lectins, one to epidermal growth factor, and two to the consensus repeat units found in C3/C4-binding proteins.<ref>{{cite web | title = Entrez Gene: SELL selectin L (lymphocyte adhesion molecule 1)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6402| accessdate = }}</ref>
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{PBB_Summary
-| section_title =
-| summary_text = SELL is a cell surface component that is a member of a family of adhesion/homing receptors which play important roles in leukocyte-endothelial cell interactions. The molecule is composed of multiple domains: one homologous to lectins, one to epidermal growth factor, and two to the consensus repeat units found in C3/C4 binding proteins.<ref>{{cite web | title = Entrez Gene: SELL selectin L (lymphocyte adhesion molecule 1)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6402| accessdate = }}</ref>
-}}
 == Ligands ==
 *[[GlyCAM-1]], found in the [[high endothelial venule]]s of the [[lymph node]]s.
 *[[CD34]], found on endothelial cells.
-*[[MadCAM-1]], found on endothelial cells of [[gut associated lymphoid tissue]].
+*[[MadCAM-1]], found on endothelial cells of [[gut-associated lymphoid tissue]].
 *[[PSGL-1]], binds with low affinity.
 == Function ==
-L-selectin acts as a "homing receptor" for leukocytes to enter secondary lymphoid tissues via the high endothelial venules. [[Ligand]]s present on [[endothelial]] cells will bind to leukocytes expressing L-selectin, which causes the leukocytes to become localised at that point<ref name="robspath">{{cite book | title=Robbins Pathologic Basis of Disease| last=Cotran| coauthors=Kumar, Collins| publisher=W.B Saunders Company| location=Philadelphia| id=0-7216-7335-X}}</ref>. The receptor is also found on the cell surfaces of "naive" [[T-lymphocytes|T cells]], which have not yet encountered their specific antigen. This surface expression is lost after the cells are activated.
+L-selectin acts as a "homing receptor" for lymphocytes to enter secondary lymphoid tissues via high endothelial venules. [[Ligand]]s present on [[endothelial]] cells will bind to lymphocytes expressing L-selectin, slowing lymphocyte trafficking through the blood, and facilitating entry into a secondary lymphoid organ at that point.<ref name="robspath">{{cite book | title=Robbins Pathologic Basis of Disease|vauthors=Robbins SL, Cotran RS, Kumar V, Collins T | publisher = W.B Saunders Company | location = Philadelphia | isbn = 0-7216-7335-X | year = 1998 }}</ref> The receptor is commonly found on the cell surfaces of [[T-lymphocytes|T cells]].  Naive T-lymphocytes, which have not yet encountered their specific antigen, need to enter secondary lymph nodes to encounter their antigen.  Central memory T-lymphocytes, which have encountered antigen, express L-selectin to localize in secondary lymphoid organs.  Here they reside ready to proliferate upon re-encountering antigen.  Effector memory T-lymphocytes do not express L-selectin, as they circulate in the periphery and have immediate effector functions upon encountering antigen.
+High expression of L-selectin on human bone marrow progenitor cells is an early sign of cells becoming committed to lymphoid differentiation.<ref name="pmid22941246">{{cite journal |vauthors=Kohn LA, Hao QL, Sasidharan R, Parekh C, Ge S, Zhu Y, Mikkola HK, Crooks GM | title = Lymphoid priming in human bone marrow begins before expression of CD10 with upregulation of L-selectin | journal = Nat. Immunol. | volume = 13 | issue = 10 | pages = 963–71 |date=October 2012 | pmid = 22941246 | doi = 10.1038/ni.2405 }}</ref>
+L-selectin is also present on the surface of human embryo trophoblasts prior to implantation into the uterus.  Similar to its function in lymphocytes, L-selectin acts as a receptor to facilitate adhesion of the embryo to the site of invasion on the surface epithelium of the uterine endometrium.  The embryo secretes human chorionic gonadotropin (hCG), which downregulates anti-adhesion factor, [[MUC-1]], located on the uterine epithelium at the site of invasion.  Removal of MUC-1 exposes the oligosaccharide ligands of the uterine epithelium, thus allowing binding by the L-selectin receptor of the trophopblast cell, followed by embryo adhesion and invasion.<ref name="pmid22374510">{{cite journal |vauthors=James JL, Carter AM, Chamley LW | title = Human placentation from nidation to 5 weeks of gestation. Part I: What do we know about formative placental development following implantation? | journal = Placenta | volume = 33 | issue = 5 | pages = 327–34 |date=May 2012 | pmid = 22374510 | doi = 10.1016/j.placenta.2012.01.020 }}</ref>
+== References ==
+{{reflist}}
 ==External links==
 * {{MeshName|L-Selectin}}
 * {{GeorgiaImmunology|1/physresp}}
-== References ==
-{{reflist|2}}
 ==Further reading==
 {{refbegin | 2}}
-{{PBB_Further_reading
+*{{cite journal  |vauthors=Ryan US, Worthington RE |title=Cell-cell contact mechanisms |journal=Curr. Opin. Immunol. |volume=4 |issue= 1 |pages= 33–7 |year= 1992 |pmid= 1375831 |doi=10.1016/0952-7915(92)90120-4  }}
-| citations =
+*{{cite journal  | author=Nicholson IC |title=CD62L (L-selectin) |journal=J. Biol. Regul. Homeost. Agents |volume=16 |issue= 2 |pages= 144–6 |year= 2003 |pmid= 12144128 |doi=  }}
-*{{cite journal  | author=Ryan US, Worthington RE |title=Cell-cell contact mechanisms. |journal=Curr. Opin. Immunol. |volume=4 |issue= 1 |pages= 33-7 |year= 1992 |pmid= 1375831 |doi=  }}
+*{{cite journal  |vauthors=Ivetic A, Ridley AJ |title=The telling tail of L-selectin |journal=Biochem. Soc. Trans. |volume=32 |issue= Pt 6 |pages= 1118–21 |year= 2005 |pmid= 15506984 |doi= 10.1042/BST0321118 }}
-*{{cite journal  | author=Nicholson IC |title=CD62L (L-selectin). |journal=J. Biol. Regul. Homeost. Agents |volume=16 |issue= 2 |pages= 144-6 |year= 2003 |pmid= 12144128 |doi=  }}
+*{{cite journal  | author=Lasky LA |title=An endothelial ligand for L-selectin is a novel mucin-like molecule |journal=Cell |volume=69 |issue= 6 |pages= 927–38 |year= 1992 |pmid= 1376638 |doi=10.1016/0092-8674(92)90612-G  |name-list-format=vanc| author2=Singer MS  | author3=Dowbenko D  | display-authors=3  | last4=Imai  | first4=Yasuyuki  | last5=Henzel  | first5=William J.  | last6=Grimley  | first6=Chris  | last7=Fennie  | first7=Christopher  | last8=Gillett  | first8=Nancy  | last9=Watson  | first9=Susan R.  }}
-*{{cite journal  | author=Ivetic A, Ridley AJ |title=The telling tail of L-selectin. |journal=Biochem. Soc. Trans. |volume=32 |issue= Pt 6 |pages= 1118-21 |year= 2005 |pmid= 15506984 |doi= 10.1042/BST0321118 }}
+*{{cite journal  | author=Ord DC |title=Structure of the gene encoding the human leukocyte adhesion molecule-1 (TQ1, Leu-8) of lymphocytes and neutrophils |journal=J. Biol. Chem. |volume=265 |issue= 14 |pages= 7760–7 |year= 1990 |pmid= 1692315 |doi=  |name-list-format=vanc| author2=Ernst TJ  | author3=Zhou LJ  | display-authors=3  | last4=Rambaldi  | first4=A  | last5=Spertini  | first5=O  | last6=Griffin  | first6=J  | last7=Tedder  | first7=TF  }}
-*{{cite journal  | author=Lasky LA, Singer MS, Dowbenko D, ''et al.'' |title=An endothelial ligand for L-selectin is a novel mucin-like molecule. |journal=Cell |volume=69 |issue= 6 |pages= 927-38 |year= 1992 |pmid= 1376638 |doi=  }}
+*{{cite journal  | author=Bevilacqua M |title=Selectins: a family of adhesion receptors |journal=Cell |volume=67 |issue= 2 |pages= 233 |year= 1991 |pmid= 1717161 |doi=10.1016/0092-8674(91)90174-W  |name-list-format=vanc| author2=Butcher E  | author3=Furie B  | display-authors=3  | last4=Furie  | first4=Bruce  | last5=Gallatin  | first5=M.  | last6=Gimbrone  | first6=M.  | last7=Harlan  | first7=J.  | last8=Kishimoto  | first8=K.  | last9=Lasky  | first9=L.  }}
-*{{cite journal  | author=Ord DC, Ernst TJ, Zhou LJ, ''et al.'' |title=Structure of the gene encoding the human leukocyte adhesion molecule-1 (TQ1, Leu-8) of lymphocytes and neutrophils. |journal=J. Biol. Chem. |volume=265 |issue= 14 |pages= 7760-7 |year= 1990 |pmid= 1692315 |doi=  }}
+*{{cite journal  | author=Tedder TF |title=Isolation and chromosomal localization of cDNAs encoding a novel human lymphocyte cell surface molecule, LAM-1. Homology with the mouse lymphocyte homing receptor and other human adhesion proteins |journal=J. Exp. Med. |volume=170 |issue= 1 |pages= 123–33 |year= 1989 |pmid= 2473156 |doi=10.1084/jem.170.1.123  | pmc=2189363  |name-list-format=vanc| author2=Isaacs CM  | author3=Ernst TJ  | display-authors=3  | last4=Demetri  | first4=GD  | last5=Adler  | first5=DA  | last6=Disteche  | first6=CM  }}
-*{{cite journal  | author=Bevilacqua M, Butcher E, Furie B, ''et al.'' |title=Selectins: a family of adhesion receptors. |journal=Cell |volume=67 |issue= 2 |pages= 233 |year= 1991 |pmid= 1717161 |doi=  }}
+*{{cite journal  |vauthors=Camerini D, James SP, Stamenkovic I, Seed B |title=Leu-8/TQ1 is the human equivalent of the Mel-14 lymph node homing receptor |journal=Nature |volume=342 |issue= 6245 |pages= 78–82 |year= 1989 |pmid= 2509939 |doi= 10.1038/342078a0 }}
-*{{cite journal  | author=Tedder TF, Isaacs CM, Ernst TJ, ''et al.'' |title=Isolation and chromosomal localization of cDNAs encoding a novel human lymphocyte cell surface molecule, LAM-1. Homology with the mouse lymphocyte homing receptor and other human adhesion proteins. |journal=J. Exp. Med. |volume=170 |issue= 1 |pages= 123-33 |year= 1989 |pmid= 2473156 |doi=  }}
+*{{cite journal  |vauthors=Bowen BR, Nguyen T, Lasky LA |title=Characterization of a human homologue of the murine peripheral lymph node homing receptor |journal=J. Cell Biol. |volume=109 |issue= 1 |pages= 421–7 |year= 1989 |pmid= 2663882 |doi=10.1083/jcb.109.1.421  | pmc=2115458  }}
-*{{cite journal  | author=Camerini D, James SP, Stamenkovic I, Seed B |title=Leu-8/TQ1 is the human equivalent of the Mel-14 lymph node homing receptor. |journal=Nature |volume=342 |issue= 6245 |pages= 78-82 |year= 1989 |pmid= 2509939 |doi= 10.1038/342078a0 }}
+*{{cite journal  |vauthors=Siegelman MH, Weissman IL |title=Human homologue of mouse lymph node homing receptor: evolutionary conservation at tandem cell interaction domains |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=86 |issue= 14 |pages= 5562–6 |year= 1989 |pmid= 2664786 |doi=10.1073/pnas.86.14.5562  | pmc=336895  }}
-*{{cite journal  | author=Bowen BR, Nguyen T, Lasky LA |title=Characterization of a human homologue of the murine peripheral lymph node homing receptor. |journal=J. Cell Biol. |volume=109 |issue= 1 |pages= 421-7 |year= 1989 |pmid= 2663882 |doi=  }}
+*{{cite journal  |vauthors=Bajorath J, Aruffo A |title=A template for generation and comparison of three-dimensional selectin models |journal=Biochem. Biophys. Res. Commun. |volume=216 |issue= 3 |pages= 1018–23 |year= 1995 |pmid= 7488174 |doi= 10.1006/bbrc.1995.2722 }}
-*{{cite journal  | author=Siegelman MH, Weissman IL |title=Human homologue of mouse lymph node homing receptor: evolutionary conservation at tandem cell interaction domains. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=86 |issue= 14 |pages= 5562-6 |year= 1989 |pmid= 2664786 |doi=  }}
+*{{cite journal  | author=Dianzani U |title=Modulation of CD4 lateral interaction with lymphocyte surface molecules induced by HIV-1 gp120 |journal=Eur. J. Immunol. |volume=25 |issue= 5 |pages= 1306–11 |year= 1995 |pmid= 7539755 |doi=10.1002/eji.1830250526  |name-list-format=vanc| author2=Bragardo M  | author3=Buonfiglio D  | display-authors=3  | last4=Redoglia  | first4=Valter  | last5=Funaro  | first5=Ada  | last6=Portoles  | first6=Pilar  | last7=Rojo  | first7=José  | last8=Malavasi  | first8=Fabio  | last9=Pileri  | first9=Alessandro  }}
-*{{cite journal  | author=Bajorath J, Aruffo A |title=A template for generation and comparison of three-dimensional selectin models. |journal=Biochem. Biophys. Res. Commun. |volume=216 |issue= 3 |pages= 1018-23 |year= 1995 |pmid= 7488174 |doi= 10.1006/bbrc.1995.2722 }}
+*{{cite journal  |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8  }}
-*{{cite journal  | author=Dianzani U, Bragardo M, Buonfiglio D, ''et al.'' |title=Modulation of CD4 lateral interaction with lymphocyte surface molecules induced by HIV-1 gp120. |journal=Eur. J. Immunol. |volume=25 |issue= 5 |pages= 1306-11 |year= 1995 |pmid= 7539755 |doi=  }}
+*{{cite journal  | author=Brenner B |title=L-selectin activates the Ras pathway via the tyrosine kinase p56lck |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 26 |pages= 15376–81 |year= 1997 |pmid= 8986819 |doi=10.1073/pnas.93.26.15376  | pmc=26412  |name-list-format=vanc| author2=Gulbins E  | author3=Schlottmann K  | display-authors=3  | last4=Koppenhoefer  | first4=U  | last5=Busch  | first5=GL  | last6=Walzog  | first6=B  | last7=Steinhausen  | first7=M  | last8=Coggeshall  | first8=KM  | last9=Linderkamp  | first9=O  }}
-*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
+*{{cite journal  | author=Zöllner O |title=L-selectin from human, but not from mouse neutrophils binds directly to E-selectin |journal=J. Cell Biol. |volume=136 |issue= 3 |pages= 707–16 |year= 1997 |pmid= 9024699 |doi=10.1083/jcb.136.3.707  | pmc=2134294  |name-list-format=vanc| author2=Lenter MC  | author3=Blanks JE  | display-authors=3  | last4=Borges  | first4=E  | last5=Steegmaier  | first5=M  | last6=Zerwes  | first6=HG  | last7=Vestweber  | first7=D  }}
-*{{cite journal  | author=Brenner B, Gulbins E, Schlottmann K, ''et al.'' |title=L-selectin activates the Ras pathway via the tyrosine kinase p56lck. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 26 |pages= 15376-81 |year= 1997 |pmid= 8986819 |doi=  }}
+*{{cite journal  | author=Suzuki Y |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3  |name-list-format=vanc| author2=Yoshitomo-Nakagawa K  | author3=Maruyama K  | display-authors=3  | last4=Suyama  | first4=A  | last5=Sugano  | first5=S  }}
-*{{cite journal  | author=Zöllner O, Lenter MC, Blanks JE, ''et al.'' |title=L-selectin from human, but not from mouse neutrophils binds directly to E-selectin. |journal=J. Cell Biol. |volume=136 |issue= 3 |pages= 707-16 |year= 1997 |pmid= 9024699 |doi=  }}
+*{{cite journal  | author=Prakobphol A |title=Human low-molecular-weight salivary mucin expresses the sialyl lewisx determinant and has L-selectin ligand activity |journal=Biochemistry |volume=37 |issue= 14 |pages= 4916–27 |year= 1998 |pmid= 9538010 |doi= 10.1021/bi972612a  |name-list-format=vanc| author2=Thomsson KA  | author3=Hansson GC  | display-authors=3  | last4=Rosen  | first4=Steven D.  | last5=Singer  | first5=Mark S.  | last6=Phillips  | first6=Nancy J.  | last7=Medzihradszky  | first7=Katalin F.  | last8=Burlingame  | first8=Alma L.  | last9=Leffler  | first9=Hakon }}
-*{{cite journal  | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
+*{{cite journal  | author=Sassetti C |title=Identification of podocalyxin-like protein as a high endothelial venule ligand for L-selectin: parallels to CD34 |journal=J. Exp. Med. |volume=187 |issue= 12 |pages= 1965–75 |year= 1998 |pmid= 9625756 |doi=10.1084/jem.187.12.1965  | pmc=2212365  |name-list-format=vanc| author2=Tangemann K  | author3=Singer MS  | display-authors=3  | last4=Kershaw  | first4=DB  | last5=Rosen  | first5=SD  }}
-*{{cite journal  | author=Prakobphol A, Thomsson KA, Hansson GC, ''et al.'' |title=Human low-molecular-weight salivary mucin expresses the sialyl lewisx determinant and has L-selectin ligand activity. |journal=Biochemistry |volume=37 |issue= 14 |pages= 4916-27 |year= 1998 |pmid= 9538010 |doi= 10.1021/bi972612a }}
+*{{cite journal  |vauthors=Malhotra R, Ward M, Sim RB, Bird MI |title=Identification of human complement Factor H as a ligand for L-selectin |journal=Biochem. J. |volume=341 |issue=  1|pages= 61–9 |year= 1999 |pmid= 10377245 |doi=10.1042/0264-6021:3410061  | pmc=1220330  }}
-*{{cite journal  | author=Sassetti C, Tangemann K, Singer MS, ''et al.'' |title=Identification of podocalyxin-like protein as a high endothelial venule ligand for L-selectin: parallels to CD34. |journal=J. Exp. Med. |volume=187 |issue= 12 |pages= 1965-75 |year= 1998 |pmid= 9625756 |doi=  }}
+*{{cite journal  |vauthors=Bradley LM, Duncan DD, Tonkonogy S, Swain SL |title=CD4+ effector T cells in vivo: immunization results in a transient population of MEL-14-, CD45RB- helper cells that secretes interleukin 2 (IL-2), IL-3, IL-4, and interferon gamma |journal=J. Exp. Med. |volume=174 |issue=3  |pages= 547–59 |year= 1999 |pmid= 1678774 |doi=10.1084/jem.174.3.547  | pmc=2118927  }}
-*{{cite journal  | author=Malhotra R, Ward M, Sim RB, Bird MI |title=Identification of human complement Factor H as a ligand for L-selectin. |journal=Biochem. J. |volume=341 ( Pt 1) |issue=  |pages= 61-9 |year= 1999 |pmid= 10377245 |doi=  }}
-}}
 {{refend}}
+{{NLM content}}
-{{NLM content}}
-{{Cell-biology-stub}}
-{{protein-stub}}
 {{Immune receptors}}
 {{Cell adhesion molecules}}
 {{Clusters of differentiation}}
-[[Category:Cell adhesion proteins]]
-{{WikiDoc Sources}}
+[[Category:Selectins]]
+[[Category:Lymphocyte homing receptors]]

v t e Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1-50	CD1 a-c 1A 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51-100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101-150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151-200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201-250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249
251-300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301-350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

L-selectin: Difference between revisions

Revision as of 17:22, 2 September 2017

Contents

Ligands

Function

References

External links

Further reading

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