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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Killer cell lectin-like receptor subfamily B, member 1''', also known as '''NK1.1''','''KLRB1''', '''NKR-P1A''' or '''CD161''' ([[cluster of differentiation]] 161), is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: KLRB1 killer cell lectin-like receptor subfamily B, member 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3820| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Killer cell lectin-like receptor subfamily B, member 1
| HGNCid = 6373
| Symbol = KLRB1
| AltSymbols =; CD161; CLEC5B; MGC138614; NKR; NKR-P1; NKR-P1A; NKRP1A; hNKR-P1A
| OMIM = 602890
| ECnumber = 
| Homologene = 84369
| MGIid = 107539
| GeneAtlas_image1 = PBB_GE_KLRB1_214470_at_tn.png
| Function = {{GNF_GO|id=GO:0004888 |text = transmembrane receptor activity}} {{GNF_GO|id=GO:0005529 |text = sugar binding}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007166 |text = cell surface receptor linked signal transduction}} {{GNF_GO|id=GO:0019735 |text = antimicrobial humoral response}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3820
    | Hs_Ensembl = ENSG00000111796
    | Hs_RefseqProtein = NP_002249
    | Hs_RefseqmRNA = NM_002258
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 12
    | Hs_GenLoc_start = 9638415
    | Hs_GenLoc_end = 9651749
    | Hs_Uniprot = Q12918
    | Mm_EntrezGene = 17058
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = NM_008526
    | Mm_RefseqProtein = NP_032552
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Killer cell lectin-like receptor subfamily B, member 1''', also known as '''KLRB1''' or '''CD161''' ([[cluster of differentiation]] 161), is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: KLRB1 killer cell lectin-like receptor subfamily B, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3820| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
Natural killer (NK) cells are lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation. Several genes of the [[C-type lectin]] superfamily, including the rodent NKRP1 family of glycoproteins, are expressed by NK cells and may be involved in the regulation of NK cell function. The KLRB1 protein contains an extracellular domain with several motifs characteristic of C-type lectins, a transmembrane domain, and a cytoplasmic domain. The KLRB1 protein, NKR-P1A or CD161, is classified as a type II membrane protein because it has an external C terminus.<ref name="entrez" /> NKR-P1A, the receptor encoded by the KLRB1 gene, recognizes [[CLEC2D|Lectin Like Transcript-1 (LLT1)]] as a functional ligand.
{{PBB_Summary
| section_title =
| summary_text = Natural killer (NK) cells are lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation. Several genes of the C-type lectin superfamily, including the rodent NKRP1 family of glycoproteins, are expressed by NK cells and may be involved in the regulation of NK cell function. The KLRB1 protein contains an extracellular domain with several motifs characteristic of C-type lectins, a transmembrane domain, and a cytoplasmic domain. The KLRB1 protein is classified as a type II membrane protein because it has an external C terminus.<ref name="entrez">{{cite web | title = Entrez Gene: KLRB1 killer cell lectin-like receptor subfamily B, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3820| accessdate = }}</ref>
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Smith FB, Connor JM, Lee AJ, Cooke A, Lowe GD, Rumley A, Fowkes FG | title = Relationship of the platelet glycoprotein PlA and fibrinogen T/G+1689 polymorphisms with peripheral arterial disease and ischaemic heart disease | journal = Thrombosis Research | volume = 112 | issue = 4 | pages = 209–16 | year = 2004 | pmid = 14987913 | doi = 10.1016/j.thromres.2003.11.010 }}
| citations =
* {{cite journal | vauthors = Lanier LL, Chang C, Phillips JH | title = Human NKR-P1A. A disulfide-linked homodimer of the C-type lectin superfamily expressed by a subset of NK and T lymphocytes | journal = Journal of Immunology | volume = 153 | issue = 6 | pages = 2417–28 | date = September 1994 | pmid = 8077657 | doi =  }}
*{{cite journal | author=Smith FB, Connor JM, Lee AJ, ''et al.'' |title=Relationship of the platelet glycoprotein PlA and fibrinogen T/G+1689 polymorphisms with peripheral arterial disease and ischaemic heart disease. |journal=Thromb. Res. |volume=112 |issue= 4 |pages= 209-16 |year= 2004 |pmid= 14987913 |doi= 10.1016/j.thromres.2003.11.010 }}
* {{cite journal | vauthors = Poggi A, Costa P, Morelli L, Cantoni C, Pella N, Spada F, Biassoni R, Nanni L, Revello V, Tomasello E, Mingari MC, Moretta A, Moretta L | title = Expression of human NKRP1A by CD34+ immature thymocytes: NKRP1A-mediated regulation of proliferation and cytolytic activity | journal = European Journal of Immunology | volume = 26 | issue = 6 | pages = 1266–72 | date = June 1996 | pmid = 8647203 | doi = 10.1002/eji.1830260613 }}
*{{cite journal | author=Lanier LL, Chang C, Phillips JH |title=Human NKR-P1A. A disulfide-linked homodimer of the C-type lectin superfamily expressed by a subset of NK and T lymphocytes. |journal=J. Immunol. |volume=153 |issue= 6 |pages= 2417-28 |year= 1994 |pmid= 8077657 |doi=  }}
* {{cite journal | vauthors = Renedo M, Arce I, Rodríguez A, Carretero M, Lanier LL, López-Botet M, Fernández-Ruiz E | title = The human natural killer gene complex is located on chromosome 12p12-p13 | journal = Immunogenetics | volume = 46 | issue = 4 | pages = 307–11 | year = 1997 | pmid = 9218532 | doi = 10.1007/s002510050276 }}
*{{cite journal | author=Poggi A, Costa P, Morelli L, ''et al.'' |title=Expression of human NKRP1A by CD34+ immature thymocytes: NKRP1A-mediated regulation of proliferation and cytolytic activity. |journal=Eur. J. Immunol. |volume=26 |issue= 6 |pages= 1266-72 |year= 1996 |pmid= 8647203 |doi= }}
* {{cite journal | vauthors = Poggi A, Costa P, Zocchi MR, Moretta L | title = Phenotypic and functional analysis of CD4+ NKRP1A+ human T lymphocytes. Direct evidence that the NKRP1A molecule is involved in transendothelial migration | journal = European Journal of Immunology | volume = 27 | issue = 9 | pages = 2345–50 | date = September 1997 | pmid = 9341779 | doi = 10.1002/eji.1830270932 }}
*{{cite journal | author=Renedo M, Arce I, Rodríguez A, ''et al.'' |title=The human natural killer gene complex is located on chromosome 12p12-p13. |journal=Immunogenetics |volume=46 |issue= 4 |pages= 307-11 |year= 1997 |pmid= 9218532 |doi= }}
* {{cite journal | vauthors = Poggi A, Rubartelli A, Moretta L, Zocchi MR | title = Expression and function of NKRP1A molecule on human monocytes and dendritic cells | journal = European Journal of Immunology | volume = 27 | issue = 11 | pages = 2965–70 | date = November 1997 | pmid = 9394825 | doi = 10.1002/eji.1830271132 }}
*{{cite journal | author=Poggi A, Costa P, Zocchi MR, Moretta L |title=Phenotypic and functional analysis of CD4+ NKRP1A+ human T lymphocytes. Direct evidence that the NKRP1A molecule is involved in transendothelial migration. |journal=Eur. J. Immunol. |volume=27 |issue= 9 |pages= 2345-50 |year= 1997 |pmid= 9341779 |doi= }}
* {{cite journal | vauthors = Poggi A, Costa P, Tomasello E, Moretta L | title = IL-12-induced up-regulation of NKRP1A expression in human NK cells and consequent NKRP1A-mediated down-regulation of NK cell activation | journal = European Journal of Immunology | volume = 28 | issue = 5 | pages = 1611–6 | date = May 1998 | pmid = 9603467 | doi = 10.1002/(SICI)1521-4141(199805)28:05<1611::AID-IMMU1611>3.0.CO;2-6 }}
*{{cite journal | author=Poggi A, Rubartelli A, Moretta L, Zocchi MR |title=Expression and function of NKRP1A molecule on human monocytes and dendritic cells. |journal=Eur. J. Immunol. |volume=27 |issue= 11 |pages= 2965-70 |year= 1998 |pmid= 9394825 |doi= }}
* {{cite journal | vauthors = Carlyle JR, Martin A, Mehra A, Attisano L, Tsui FW, Zúñiga-Pflücker JC | title = Mouse NKR-P1B, a novel NK1.1 antigen with inhibitory function | journal = Journal of Immunology | volume = 162 | issue = 10 | pages = 5917–23 | date = May 1999 | pmid = 10229828 | doi =  }}
*{{cite journal | author=Poggi A, Costa P, Tomasello E, Moretta L |title=IL-12-induced up-regulation of NKRP1A expression in human NK cells and consequent NKRP1A-mediated down-regulation of NK cell activation. |journal=Eur. J. Immunol. |volume=28 |issue= 5 |pages= 1611-6 |year= 1998 |pmid= 9603467 |doi= }}
* {{cite journal | vauthors = Ishihara S, Nieda M, Kitayama J, Osada T, Yabe T, Ishikawa Y, Nagawa H, Muto T, Juji T | title = CD8(+)NKR-P1A (+)T cells preferentially accumulate in human liver | journal = European Journal of Immunology | volume = 29 | issue = 8 | pages = 2406–13 | date = August 1999 | pmid = 10458753 | doi = 10.1002/(SICI)1521-4141(199908)29:08<2406::AID-IMMU2406>3.0.CO;2-F }}
*{{cite journal | author=Carlyle JR, Martin A, Mehra A, ''et al.'' |title=Mouse NKR-P1B, a novel NK1.1 antigen with inhibitory function. |journal=J. Immunol. |volume=162 |issue= 10 |pages= 5917-23 |year= 1999 |pmid= 10229828 |doi=  }}
* {{cite journal | vauthors = Iiai T, Watanabe H, Suda T, Okamoto H, Abo T, Hatakeyama K | title = CD161+ T (NT) cells exist predominantly in human intestinal epithelium as well as in liver | journal = Clinical and Experimental Immunology | volume = 129 | issue = 1 | pages = 92–8 | date = July 2002 | pmid = 12100027 | pmc = 1906419 | doi = 10.1046/j.1365-2249.2002.01886.x }}
*{{cite journal | author=Ishihara S, Nieda M, Kitayama J, ''et al.'' |title=CD8(+)NKR-P1A (+)T cells preferentially accumulate in human liver. |journal=Eur. J. Immunol. |volume=29 |issue= 8 |pages= 2406-13 |year= 1999 |pmid= 10458753 |doi= }}
* {{cite journal | vauthors = Iizuka K, Naidenko OV, Plougastel BF, Fremont DH, Yokoyama WM | title = Genetically linked C-type lectin-related ligands for the NKRP1 family of natural killer cell receptors | journal = Nature Immunology | volume = 4 | issue = 8 | pages = 801–7 | date = August 2003 | pmid = 12858173 | doi = 10.1038/ni954 }}
*{{cite journal | author=Iiai T, Watanabe H, Suda T, ''et al.'' |title=CD161+ T (NT) cells exist predominantly in human intestinal epithelium as well as in liver. |journal=Clin. Exp. Immunol. |volume=129 |issue= 1 |pages= 92-8 |year= 2002 |pmid= 12100027 |doi= }}
* {{cite journal | vauthors = Carlyle JR, Jamieson AM, Gasser S, Clingan CS, Arase H, Raulet DH | title = Missing self-recognition of Ocil/Clr-b by inhibitory NKR-P1 natural killer cell receptors | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 101 | issue = 10 | pages = 3527–32 | date = March 2004 | pmid = 14990792 | pmc = 373496 | doi = 10.1073/pnas.0308304101 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Aldemir H, Prod'homme V, Dumaurier MJ, Retiere C, Poupon G, Cazareth J, Bihl F, Braud VM | title = Cutting edge: lectin-like transcript 1 is a ligand for the CD161 receptor | journal = Journal of Immunology | volume = 175 | issue = 12 | pages = 7791–5 | date = December 2005 | pmid = 16339512 | doi = 10.4049/jimmunol.175.12.7791 }}
*{{cite journal | author=Iizuka K, Naidenko OV, Plougastel BF, ''et al.'' |title=Genetically linked C-type lectin-related ligands for the NKRP1 family of natural killer cell receptors. |journal=Nat. Immunol. |volume=4 |issue= 8 |pages= 801-7 |year= 2003 |pmid= 12858173 |doi= 10.1038/ni954 }}
* {{cite journal | vauthors = Rosen DB, Bettadapura J, Alsharifi M, Mathew PA, Warren HS, Lanier LL | title = Cutting edge: lectin-like transcript-1 is a ligand for the inhibitory human NKR-P1A receptor | journal = Journal of Immunology | volume = 175 | issue = 12 | pages = 7796–9 | date = December 2005 | pmid = 16339513 | doi = 10.4049/jimmunol.175.12.7796 }}
*{{cite journal | author=Carlyle JR, Jamieson AM, Gasser S, ''et al.'' |title=Missing self-recognition of Ocil/Clr-b by inhibitory NKR-P1 natural killer cell receptors. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 10 |pages= 3527-32 |year= 2004 |pmid= 14990792 |doi= 10.1073/pnas.0308304101 }}
* {{cite journal | vauthors = Pozo D, Valés-Gómez M, Mavaddat N, Williamson SC, Chisholm SE, Reyburn H | title = CD161 (human NKR-P1A) signaling in NK cells involves the activation of acid sphingomyelinase | journal = Journal of Immunology | volume = 176 | issue = 4 | pages = 2397–406 | date = February 2006 | pmid = 16455998 | doi = 10.4049/jimmunol.176.4.2397 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
* {{cite journal | vauthors = Christiansen D, Mouhtouris E, Milland J, Zingoni A, Santoni A, Sandrin MS | title = Recognition of a carbohydrate xenoepitope by human NKRP1A (CD161) | journal = Xenotransplantation | volume = 13 | issue = 5 | pages = 440–6 | date = September 2006 | pmid = 16925668 | doi = 10.1111/j.1399-3089.2006.00332.x }}
*{{cite journal  | author=Aldemir H, Prod'homme V, Dumaurier MJ, ''et al.'' |title=Cutting edge: lectin-like transcript 1 is a ligand for the CD161 receptor. |journal=J. Immunol. |volume=175 |issue= 12 |pages= 7791-5 |year= 2006 |pmid= 16339512 |doi= }}
* {{cite journal | vauthors = Rosen DB, Cao W, Avery DT, Tangye SG, Liu YJ, Houchins JP, Lanier LL | title = Functional consequences of interactions between human NKR-P1A and its ligand LLT1 expressed on activated dendritic cells and B cells | journal = Journal of Immunology | volume = 180 | issue = 10 | pages = 6508–17 | date = May 2008 | pmid = 18453569 | pmc = 2577150 | doi = 10.4049/jimmunol.180.10.6508 }}
*{{cite journal | author=Rosen DB, Bettadapura J, Alsharifi M, ''et al.'' |title=Cutting edge: lectin-like transcript-1 is a ligand for the inhibitory human NKR-P1A receptor. |journal=J. Immunol. |volume=175 |issue= 12 |pages= 7796-9 |year= 2006 |pmid= 16339513 |doi= }}
*{{cite journal | author=Pozo D, Valés-Gómez M, Mavaddat N, ''et al.'' |title=CD161 (human NKR-P1A) signaling in NK cells involves the activation of acid sphingomyelinase. |journal=J. Immunol. |volume=176 |issue= 4 |pages= 2397-406 |year= 2006 |pmid= 16455998 |doi= }}
*{{cite journal | author=Christiansen D, Mouhtouris E, Milland J, ''et al.'' |title=Recognition of a carbohydrate xenoepitope by human NKRP1A (CD161). |journal=Xenotransplantation |volume=13 |issue= 5 |pages= 440-6 |year= 2007 |pmid= 16925668 |doi= 10.1111/j.1399-3089.2006.00332.x }}
}}
{{refend}}
{{refend}}


{{membrane-protein-stub}}
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{{Clusters of differentiation}}
{{Clusters of differentiation}}
[[Category:Clusters of differentiation]]
[[Category:Clusters of differentiation]]
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Latest revision as of 15:04, 8 November 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Killer cell lectin-like receptor subfamily B, member 1, also known as NK1.1,KLRB1, NKR-P1A or CD161 (cluster of differentiation 161), is a human gene.[1]

Function

Natural killer (NK) cells are lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation. Several genes of the C-type lectin superfamily, including the rodent NKRP1 family of glycoproteins, are expressed by NK cells and may be involved in the regulation of NK cell function. The KLRB1 protein contains an extracellular domain with several motifs characteristic of C-type lectins, a transmembrane domain, and a cytoplasmic domain. The KLRB1 protein, NKR-P1A or CD161, is classified as a type II membrane protein because it has an external C terminus.[1] NKR-P1A, the receptor encoded by the KLRB1 gene, recognizes Lectin Like Transcript-1 (LLT1) as a functional ligand.

References

  1. ↑ 1.0 1.1 "Entrez Gene: KLRB1 killer cell lectin-like receptor subfamily B, member 1".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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