KLK6: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Kallikrein-6''' is a [[protein]] that in humans is encoded by the ''KLK6'' [[gene]].<ref name="pmid9003450">{{cite journal | vauthors = Yamashiro K, Tsuruoka N, Kodama S, Tsujimoto M, Yamamura Y, Tanaka T, Nakazato H, Yamaguchi N | title = Molecular cloning of a novel trypsin-like serine protease (neurosin) preferentially expressed in brain | journal = Biochimica et Biophysica Acta | volume = 1350 | issue = 1 | pages = 11–4 | date = Jan 1997 | pmid = 9003450 | pmc =  | doi = 10.1016/s0167-4781(96)00187-x }}</ref><ref name="pmid16800724">{{cite journal | vauthors = Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis EP, Fritz H, Lilja H, Malm J, Maltais LJ, Olsson AY, Petraki C, Scorilas A, Sotiropoulou G, Stenman UH, Stephan C, Talieri M, Yousef GM | title = A comprehensive nomenclature for serine proteases with homology to tissue kallikreins | journal = Biological Chemistry | volume = 387 | issue = 6 | pages = 637–41 | date = Jun 2006 | pmid = 16800724 | pmc =  | doi = 10.1515/BC.2006.082 }}</ref><ref name="pmid16800723">{{cite journal | vauthors =  | title = Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005 | journal = Biological Chemistry | volume = 387 | issue = 6 | pages = 635–824 | date = Jun 2006 | pmid = 16800723 | pmc = | doi = 10.1515/BC.2006.081 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: KLK6 kallikrein-related peptidase 6| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5653| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_KLK6_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1gvl.
| PDB = {{PDB2|1gvl}}, {{PDB2|1l2e}}, {{PDB2|1lo6}}
| Name = Kallikrein-related peptidase 6
| HGNCid = 6367
| Symbol = KLK6
| AltSymbols =; ZYME; Bssp; Klk7; MGC9355; NEUROSIN; PRSS18; PRSS9; SP59; hK6
| OMIM = 602652
| ECnumber = 
| Homologene = 68279
| MGIid = 1343166
| GeneAtlas_image1 = PBB_GE_KLK6_204733_at_tn.png
| Function = {{GNF_GO|id=GO:0004252 |text = serine-type endopeptidase activity}} {{GNF_GO|id=GO:0004293 |text = tissue kallikrein activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008233 |text = peptidase activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006508 |text = proteolysis}} {{GNF_GO|id=GO:0007417 |text = central nervous system development}} {{GNF_GO|id=GO:0009611 |text = response to wounding}} {{GNF_GO|id=GO:0016540 |text = protein autoprocessing}} {{GNF_GO|id=GO:0030574 |text = collagen catabolic process}} {{GNF_GO|id=GO:0042246 |text = tissue regeneration}} {{GNF_GO|id=GO:0042445 |text = hormone metabolic process}} {{GNF_GO|id=GO:0042552 |text = myelination}} {{GNF_GO|id=GO:0042982 |text = amyloid precursor protein metabolic process}} {{GNF_GO|id=GO:0045595 |text = regulation of cell differentiation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5653
    | Hs_Ensembl = ENSG00000167755
    | Hs_RefseqProtein = NP_001012982
    | Hs_RefseqmRNA = NM_001012964
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 56153700
    | Hs_GenLoc_end = 56164741
    | Hs_Uniprot = Q92876
    | Mm_EntrezGene = 19144
    | Mm_Ensembl = ENSMUSG00000050063
    | Mm_RefseqmRNA = NM_011177
    | Mm_RefseqProtein = NP_035307
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 43692600
    | Mm_GenLoc_end = 43699828
    | Mm_Uniprot = 
  }}
}}
'''Kallikrein-related peptidase 6''', also known as '''KLK6''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: KLK6 kallikrein-related peptidase 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5653| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
[[Kallikrein]]s are a subgroup of serine [[protease]]s having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in [[carcinogenesis]] and some have potential as novel cancer and other disease [[biomarker]]s. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. The encoded enzyme is regulated by steroid hormones. In tissue culture, the enzyme has been found to generate amyloidogenic fragments from the [[amyloid precursor protein]], suggesting a potential for involvement in [[Alzheimer's disease]]. Multiple alternatively spliced transcript variants that encode different isoforms have been identified for this gene.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. The encoded enzyme is regulated by steroid hormones. In tissue culture, the enzyme has been found to generate amyloidogenic fragments from the amyloid precursor protein, suggesting a potential for involvement in Alzheimer's disease. Multiple alternatively spliced transcript variants that encode different isoforms have been identified for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: KLK6 kallikrein-related peptidase 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5653| accessdate = }}</ref>
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Yousef GM, Kishi T, Diamandis EP | title = Role of kallikrein enzymes in the central nervous system | journal = Clinica Chimica Acta; International Journal of Clinical Chemistry | volume = 329 | issue = 1-2 | pages = 1–8 | date = Mar 2003 | pmid = 12589961 | doi = 10.1016/S0009-8981(03)00004-4 }}
| citations =
* {{cite journal | vauthors = Menendez-Gonzalez M, Castro-Santos P, Suarez A, Calatayud MT, Perez-Pinera P, Martinez M, Ribacoba R, Gutierrez C | title = Value of measuring plasmatic levels of neurosin in the diagnosis of Alzheimer's disease | journal = Journal of Alzheimer's Disease | volume = 14 | issue = 1 | pages = 59–67 | date = May 2008 | pmid = 18525128 }}
*{{cite journal | author=Yousef GM, Kishi T, Diamandis EP |title=Role of kallikrein enzymes in the central nervous system. |journal=Clin. Chim. Acta |volume=329 |issue= 1-2 |pages= 1-8 |year= 2003 |pmid= 12589961 |doi= }}
* {{cite journal | vauthors = Menendez-Gonzalez M, Castro-Santos P, Calatayud MT, Perez-Piñera P, Ribacoba R, Martinez-Rivera M, Gutierrez C, Lopez-Muñiz A, Suarez A | title = Plasmatic level of neurosin predicts outcome of mild cognitive impairment | journal = International Archives of Medicine | volume = 1 | issue = 1 | pages = 11 | year = 2008 | pmid = 18620574 | pmc = 2475518 | doi = 10.1186/1755-7682-1-11 }}
*{{cite journal | author=Anisowicz A, Sotiropoulou G, Stenman G, ''et al.'' |title=A novel protease homolog differentially expressed in breast and ovarian cancer. |journal=Mol. Med. |volume=2 |issue= 5 |pages= 624-36 |year= 1997 |pmid= 8898378 |doi=  }}
* {{cite journal | vauthors = Anisowicz A, Sotiropoulou G, Stenman G, Mok SC, Sager R | title = A novel protease homolog differentially expressed in breast and ovarian cancer | journal = Molecular Medicine | volume = 2 | issue = 5 | pages = 624–36 | date = Sep 1996 | pmid = 8898378 | pmc = 2230195 | doi =  }}
*{{cite journal | author=Yamashiro K, Tsuruoka N, Kodama S, ''et al.'' |title=Molecular cloning of a novel trypsin-like serine protease (neurosin) preferentially expressed in brain. |journal=Biochim. Biophys. Acta |volume=1350 |issue= 1 |pages= 11-4 |year= 1997 |pmid= 9003450 |doi= }}
* {{cite journal | vauthors = Little SP, Dixon EP, Norris F, Buckley W, Becker GW, Johnson M, Dobbins JR, Wyrick T, Miller JR, MacKellar W, Hepburn D, Corvalan J, McClure D, Liu X, Stephenson D, Clemens J, Johnstone EM | title = Zyme, a novel and potentially amyloidogenic enzyme cDNA isolated from Alzheimer's disease brain | journal = The Journal of Biological Chemistry | volume = 272 | issue = 40 | pages = 25135–42 | date = Oct 1997 | pmid = 9312124 | doi = 10.1074/jbc.272.40.25135 }}
*{{cite journal | author=Little SP, Dixon EP, Norris F, ''et al.'' |title=Zyme, a novel and potentially amyloidogenic enzyme cDNA isolated from Alzheimer's disease brain. |journal=J. Biol. Chem. |volume=272 |issue= 40 |pages= 25135-42 |year= 1997 |pmid= 9312124 |doi=  }}
* {{cite journal | vauthors = Yousef GM, Luo LY, Scherer SW, Sotiropoulou G, Diamandis EP | title = Molecular characterization of zyme/protease M/neurosin (PRSS9), a hormonally regulated kallikrein-like serine protease | journal = Genomics | volume = 62 | issue = 2 | pages = 251–9 | date = Dec 1999 | pmid = 10610719 | doi = 10.1006/geno.1999.6012 }}
*{{cite journal | author=Yousef GM, Luo LY, Scherer SW, ''et al.'' |title=Molecular characterization of zyme/protease M/neurosin (PRSS9), a hormonally regulated kallikrein-like serine protease. |journal=Genomics |volume=62 |issue= 2 |pages= 251-9 |year= 2000 |pmid= 10610719 |doi= 10.1006/geno.1999.6012 }}
* {{cite journal | vauthors = Gan L, Lee I, Smith R, Argonza-Barrett R, Lei H, McCuaig J, Moss P, Paeper B, Wang K | title = Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region | journal = Gene | volume = 257 | issue = 1 | pages = 119–30 | date = Oct 2000 | pmid = 11054574 | doi = 10.1016/S0378-1119(00)00382-6 }}
*{{cite journal | author=Gan L, Lee I, Smith R, ''et al.'' |title=Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region. |journal=Gene |volume=257 |issue= 1 |pages= 119-30 |year= 2001 |pmid= 11054574 |doi= }}
* {{cite journal | vauthors = Petraki CD, Karavana VN, Skoufogiannis PT, Little SP, Howarth DJ, Yousef GM, Diamandis EP | title = The spectrum of human kallikrein 6 (zyme/protease M/neurosin) expression in human tissues as assessed by immunohistochemistry | journal = The Journal of Histochemistry and Cytochemistry | volume = 49 | issue = 11 | pages = 1431–41 | date = Nov 2001 | pmid = 11668196 | doi = 10.1177/002215540104901111 }}
*{{cite journal | author=Petraki CD, Karavana VN, Skoufogiannis PT, ''et al.'' |title=The spectrum of human kallikrein 6 (zyme/protease M/neurosin) expression in human tissues as assessed by immunohistochemistry. |journal=J. Histochem. Cytochem. |volume=49 |issue= 11 |pages= 1431-41 |year= 2001 |pmid= 11668196 |doi= }}
* {{cite journal | vauthors = Bernett MJ, Blaber SI, Scarisbrick IA, Dhanarajan P, Thompson SM, Blaber M | title = Crystal structure and biochemical characterization of human kallikrein 6 reveals that a trypsin-like kallikrein is expressed in the central nervous system | journal = The Journal of Biological Chemistry | volume = 277 | issue = 27 | pages = 24562–70 | date = Jul 2002 | pmid = 11983703 | doi = 10.1074/jbc.M202392200 }}
*{{cite journal | author=Bernett MJ, Blaber SI, Scarisbrick IA, ''et al.'' |title=Crystal structure and biochemical characterization of human kallikrein 6 reveals that a trypsin-like kallikrein is expressed in the central nervous system. |journal=J. Biol. Chem. |volume=277 |issue= 27 |pages= 24562-70 |year= 2002 |pmid= 11983703 |doi= 10.1074/jbc.M202392200 }}
* {{cite journal | vauthors = Gomis-Rüth FX, Bayés A, Sotiropoulou G, Pampalakis G, Tsetsenis T, Villegas V, Avilés FX, Coll M | title = The structure of human prokallikrein 6 reveals a novel activation mechanism for the kallikrein family | journal = The Journal of Biological Chemistry | volume = 277 | issue = 30 | pages = 27273–81 | date = Jul 2002 | pmid = 12016211 | doi = 10.1074/jbc.M201534200 }}
*{{cite journal | author=Gomis-Rüth FX, Bayés A, Sotiropoulou G, ''et al.'' |title=The structure of human prokallikrein 6 reveals a novel activation mechanism for the kallikrein family. |journal=J. Biol. Chem. |volume=277 |issue= 30 |pages= 27273-81 |year= 2002 |pmid= 12016211 |doi= 10.1074/jbc.M201534200 }}
* {{cite journal | vauthors = Scarisbrick IA, Blaber SI, Lucchinetti CF, Genain CP, Blaber M, Rodriguez M | title = Activity of a newly identified serine protease in CNS demyelination | journal = Brain | volume = 125 | issue = Pt 6 | pages = 1283–96 | date = Jun 2002 | pmid = 12023317 | doi = 10.1093/brain/awf142 }}
*{{cite journal | author=Scarisbrick IA, Blaber SI, Lucchinetti CF, ''et al.'' |title=Activity of a newly identified serine protease in CNS demyelination. |journal=Brain |volume=125 |issue= Pt 6 |pages= 1283-96 |year= 2002 |pmid= 12023317 |doi= }}
* {{cite journal | vauthors = Zarghooni M, Soosaipillai A, Grass L, Scorilas A, Mirazimi N, Diamandis EP | title = Decreased concentration of human kallikrein 6 in brain extracts of Alzheimer's disease patients | journal = Clinical Biochemistry | volume = 35 | issue = 3 | pages = 225–31 | date = May 2002 | pmid = 12074831 | doi = 10.1016/S0009-9120(02)00292-8 }}
*{{cite journal | author=Zarghooni M, Soosaipillai A, Grass L, ''et al.'' |title=Decreased concentration of human kallikrein 6 in brain extracts of Alzheimer's disease patients. |journal=Clin. Biochem. |volume=35 |issue= 3 |pages= 225-31 |year= 2002 |pmid= 12074831 |doi= }}
* {{cite journal | vauthors = Hoffman BR, Katsaros D, Scorilas A, Diamandis P, Fracchioli S, Rigault de la Longrais IA, Colgan T, Puopolo M, Giardina G, Massobrio M, Diamandis EP | title = Immunofluorometric quantitation and histochemical localisation of kallikrein 6 protein in ovarian cancer tissue: a new independent unfavourable prognostic biomarker | journal = British Journal of Cancer | volume = 87 | issue = 7 | pages = 763–71 | date = Sep 2002 | pmid = 12232761 | pmc = 2364256 | doi = 10.1038/sj.bjc.6600533 }}
*{{cite journal | author=Hoffman BR, Katsaros D, Scorilas A, ''et al.'' |title=Immunofluorometric quantitation and histochemical localisation of kallikrein 6 protein in ovarian cancer tissue: a new independent unfavourable prognostic biomarker. |journal=Br. J. Cancer |volume=87 |issue= 7 |pages= 763-71 |year= 2002 |pmid= 12232761 |doi= 10.1038/sj.bjc.6600533 }}
* {{cite journal | vauthors = Mitsui S, Okui A, Uemura H, Mizuno T, Yamada T, Yamamura Y, Yamaguchi N | title = Decreased cerebrospinal fluid levels of neurosin (KLK6), an aging-related protease, as a possible new risk factor for Alzheimer's disease | journal = Annals of the New York Academy of Sciences | volume = 977 | issue =  | pages = 216–23 | date = Nov 2002 | pmid = 12480753 | doi = 10.1111/j.1749-6632.2002.tb04818.x }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Hutchinson S, Luo LY, Yousef GM, Soosaipillai A, Diamandis EP | title = Purification of human kallikrein 6 from biological fluids and identification of its complex with alpha(1)-antichymotrypsin | journal = Clinical Chemistry | volume = 49 | issue = 5 | pages = 746–51 | date = May 2003 | pmid = 12709365 | doi = 10.1373/49.5.746 }}
*{{cite journal | author=Mitsui S, Okui A, Uemura H, ''et al.'' |title=Decreased cerebrospinal fluid levels of neurosin (KLK6), an aging-related protease, as a possible new risk factor for Alzheimer's disease. |journal=Ann. N. Y. Acad. Sci. |volume=977 |issue=  |pages= 216-23 |year= 2003 |pmid= 12480753 |doi= }}
* {{cite journal | vauthors = Magklara A, Mellati AA, Wasney GA, Little SP, Sotiropoulou G, Becker GW, Diamandis EP | title = Characterization of the enzymatic activity of human kallikrein 6: Autoactivation, substrate specificity, and regulation by inhibitors | journal = Biochemical and Biophysical Research Communications | volume = 307 | issue = 4 | pages = 948–55 | date = Aug 2003 | pmid = 12878203 | doi = 10.1016/S0006-291X(03)01271-3 }}
*{{cite journal | author=Hutchinson S, Luo LY, Yousef GM, ''et al.'' |title=Purification of human kallikrein 6 from biological fluids and identification of its complex with alpha(1)-antichymotrypsin. |journal=Clin. Chem. |volume=49 |issue= 5 |pages= 746-51 |year= 2003 |pmid= 12709365 |doi= }}
* {{cite journal | vauthors = Iwata A, Maruyama M, Akagi T, Hashikawa T, Kanazawa I, Tsuji S, Nukina N | title = Alpha-synuclein degradation by serine protease neurosin: implication for pathogenesis of synucleinopathies | journal = Human Molecular Genetics | volume = 12 | issue = 20 | pages = 2625–35 | date = Oct 2003 | pmid = 12928483 | doi = 10.1093/hmg/ddg283 }}
*{{cite journal | author=Magklara A, Mellati AA, Wasney GA, ''et al.'' |title=Characterization of the enzymatic activity of human kallikrein 6: Autoactivation, substrate specificity, and regulation by inhibitors. |journal=Biochem. Biophys. Res. Commun. |volume=307 |issue= 4 |pages= 948-55 |year= 2003 |pmid= 12878203 |doi= }}
* {{cite journal | vauthors = Sauter ER, Lininger J, Magklara A, Hewett JE, Diamandis EP | title = Association of kallikrein expression in nipple aspirate fluid with breast cancer risk | journal = International Journal of Cancer | volume = 108 | issue = 4 | pages = 588–91 | date = Feb 2004 | pmid = 14696124 | doi = 10.1002/ijc.11607 }}
*{{cite journal | author=Iwata A, Maruyama M, Akagi T, ''et al.'' |title=Alpha-synuclein degradation by serine protease neurosin: implication for pathogenesis of synucleinopathies. |journal=Hum. Mol. Genet. |volume=12 |issue= 20 |pages= 2625-35 |year= 2004 |pmid= 12928483 |doi= 10.1093/hmg/ddg283 }}
* {{cite journal | vauthors = Pampalakis G, Kurlender L, Diamandis EP, Sotiropoulou G | title = Cloning and characterization of novel isoforms of the human kallikrein 6 gene | journal = Biochemical and Biophysical Research Communications | volume = 320 | issue = 1 | pages = 54–61 | date = Jul 2004 | pmid = 15207701 | doi = 10.1016/j.bbrc.2004.04.205 }}
*{{cite journal | author=Sauter ER, Lininger J, Magklara A, ''et al.'' |title=Association of kallikrein expression in nipple aspirate fluid with breast cancer risk. |journal=Int. J. Cancer |volume=108 |issue= 4 |pages= 588-91 |year= 2004 |pmid= 14696124 |doi= 10.1002/ijc.11607 }}
*{{cite journal | author=Pampalakis G, Kurlender L, Diamandis EP, Sotiropoulou G |title=Cloning and characterization of novel isoforms of the human kallikrein 6 gene. |journal=Biochem. Biophys. Res. Commun. |volume=320 |issue= 1 |pages= 54-61 |year= 2004 |pmid= 15207701 |doi= 10.1016/j.bbrc.2004.04.205 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
== External links ==
{{WikiDoc Sources}}
* The [[MEROPS]] online database for peptidases and their inhibitors: [http://merops.sanger.ac.uk/cgi-bin/merops.cgi?id=S01.236 S01.236]
 
{{PDB Gallery|geneid=5653}}

Latest revision as of 22:00, 25 November 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Kallikrein-6 is a protein that in humans is encoded by the KLK6 gene.[1][2][3][4]

Function

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. The encoded enzyme is regulated by steroid hormones. In tissue culture, the enzyme has been found to generate amyloidogenic fragments from the amyloid precursor protein, suggesting a potential for involvement in Alzheimer's disease. Multiple alternatively spliced transcript variants that encode different isoforms have been identified for this gene.[4]

References

  1. ↑ Yamashiro K, Tsuruoka N, Kodama S, Tsujimoto M, Yamamura Y, Tanaka T, Nakazato H, Yamaguchi N (Jan 1997). "Molecular cloning of a novel trypsin-like serine protease (neurosin) preferentially expressed in brain". Biochimica et Biophysica Acta. 1350 (1): 11–4. doi:10.1016/s0167-4781(96)00187-x. PMID 9003450.
  2. ↑ Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis EP, Fritz H, Lilja H, Malm J, Maltais LJ, Olsson AY, Petraki C, Scorilas A, Sotiropoulou G, Stenman UH, Stephan C, Talieri M, Yousef GM (Jun 2006). "A comprehensive nomenclature for serine proteases with homology to tissue kallikreins". Biological Chemistry. 387 (6): 637–41. doi:10.1515/BC.2006.082. PMID 16800724.
  3. ↑ "Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005". Biological Chemistry. 387 (6): 635–824. Jun 2006. doi:10.1515/BC.2006.081. PMID 16800723.
  4. ↑ 4.0 4.1 "Entrez Gene: KLK6 kallikrein-related peptidase 6".

Further reading

  • Yousef GM, Kishi T, Diamandis EP (Mar 2003). "Role of kallikrein enzymes in the central nervous system". Clinica Chimica Acta; International Journal of Clinical Chemistry. 329 (1–2): 1–8. doi:10.1016/S0009-8981(03)00004-4. PMID 12589961.
  • Menendez-Gonzalez M, Castro-Santos P, Suarez A, Calatayud MT, Perez-Pinera P, Martinez M, Ribacoba R, Gutierrez C (May 2008). "Value of measuring plasmatic levels of neurosin in the diagnosis of Alzheimer's disease". Journal of Alzheimer's Disease. 14 (1): 59–67. PMID 18525128.
  • Menendez-Gonzalez M, Castro-Santos P, Calatayud MT, Perez-Piñera P, Ribacoba R, Martinez-Rivera M, Gutierrez C, Lopez-Muñiz A, Suarez A (2008). "Plasmatic level of neurosin predicts outcome of mild cognitive impairment". International Archives of Medicine. 1 (1): 11. doi:10.1186/1755-7682-1-11. PMC 2475518. PMID 18620574.
  • Anisowicz A, Sotiropoulou G, Stenman G, Mok SC, Sager R (Sep 1996). "A novel protease homolog differentially expressed in breast and ovarian cancer". Molecular Medicine. 2 (5): 624–36. PMC 2230195. PMID 8898378.
  • Little SP, Dixon EP, Norris F, Buckley W, Becker GW, Johnson M, Dobbins JR, Wyrick T, Miller JR, MacKellar W, Hepburn D, Corvalan J, McClure D, Liu X, Stephenson D, Clemens J, Johnstone EM (Oct 1997). "Zyme, a novel and potentially amyloidogenic enzyme cDNA isolated from Alzheimer's disease brain". The Journal of Biological Chemistry. 272 (40): 25135–42. doi:10.1074/jbc.272.40.25135. PMID 9312124.
  • Yousef GM, Luo LY, Scherer SW, Sotiropoulou G, Diamandis EP (Dec 1999). "Molecular characterization of zyme/protease M/neurosin (PRSS9), a hormonally regulated kallikrein-like serine protease". Genomics. 62 (2): 251–9. doi:10.1006/geno.1999.6012. PMID 10610719.
  • Gan L, Lee I, Smith R, Argonza-Barrett R, Lei H, McCuaig J, Moss P, Paeper B, Wang K (Oct 2000). "Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region". Gene. 257 (1): 119–30. doi:10.1016/S0378-1119(00)00382-6. PMID 11054574.
  • Petraki CD, Karavana VN, Skoufogiannis PT, Little SP, Howarth DJ, Yousef GM, Diamandis EP (Nov 2001). "The spectrum of human kallikrein 6 (zyme/protease M/neurosin) expression in human tissues as assessed by immunohistochemistry". The Journal of Histochemistry and Cytochemistry. 49 (11): 1431–41. doi:10.1177/002215540104901111. PMID 11668196.
  • Bernett MJ, Blaber SI, Scarisbrick IA, Dhanarajan P, Thompson SM, Blaber M (Jul 2002). "Crystal structure and biochemical characterization of human kallikrein 6 reveals that a trypsin-like kallikrein is expressed in the central nervous system". The Journal of Biological Chemistry. 277 (27): 24562–70. doi:10.1074/jbc.M202392200. PMID 11983703.
  • Gomis-Rüth FX, Bayés A, Sotiropoulou G, Pampalakis G, Tsetsenis T, Villegas V, Avilés FX, Coll M (Jul 2002). "The structure of human prokallikrein 6 reveals a novel activation mechanism for the kallikrein family". The Journal of Biological Chemistry. 277 (30): 27273–81. doi:10.1074/jbc.M201534200. PMID 12016211.
  • Scarisbrick IA, Blaber SI, Lucchinetti CF, Genain CP, Blaber M, Rodriguez M (Jun 2002). "Activity of a newly identified serine protease in CNS demyelination". Brain. 125 (Pt 6): 1283–96. doi:10.1093/brain/awf142. PMID 12023317.
  • Zarghooni M, Soosaipillai A, Grass L, Scorilas A, Mirazimi N, Diamandis EP (May 2002). "Decreased concentration of human kallikrein 6 in brain extracts of Alzheimer's disease patients". Clinical Biochemistry. 35 (3): 225–31. doi:10.1016/S0009-9120(02)00292-8. PMID 12074831.
  • Hoffman BR, Katsaros D, Scorilas A, Diamandis P, Fracchioli S, Rigault de la Longrais IA, Colgan T, Puopolo M, Giardina G, Massobrio M, Diamandis EP (Sep 2002). "Immunofluorometric quantitation and histochemical localisation of kallikrein 6 protein in ovarian cancer tissue: a new independent unfavourable prognostic biomarker". British Journal of Cancer. 87 (7): 763–71. doi:10.1038/sj.bjc.6600533. PMC 2364256. PMID 12232761.
  • Mitsui S, Okui A, Uemura H, Mizuno T, Yamada T, Yamamura Y, Yamaguchi N (Nov 2002). "Decreased cerebrospinal fluid levels of neurosin (KLK6), an aging-related protease, as a possible new risk factor for Alzheimer's disease". Annals of the New York Academy of Sciences. 977: 216–23. doi:10.1111/j.1749-6632.2002.tb04818.x. PMID 12480753.
  • Hutchinson S, Luo LY, Yousef GM, Soosaipillai A, Diamandis EP (May 2003). "Purification of human kallikrein 6 from biological fluids and identification of its complex with alpha(1)-antichymotrypsin". Clinical Chemistry. 49 (5): 746–51. doi:10.1373/49.5.746. PMID 12709365.
  • Magklara A, Mellati AA, Wasney GA, Little SP, Sotiropoulou G, Becker GW, Diamandis EP (Aug 2003). "Characterization of the enzymatic activity of human kallikrein 6: Autoactivation, substrate specificity, and regulation by inhibitors". Biochemical and Biophysical Research Communications. 307 (4): 948–55. doi:10.1016/S0006-291X(03)01271-3. PMID 12878203.
  • Iwata A, Maruyama M, Akagi T, Hashikawa T, Kanazawa I, Tsuji S, Nukina N (Oct 2003). "Alpha-synuclein degradation by serine protease neurosin: implication for pathogenesis of synucleinopathies". Human Molecular Genetics. 12 (20): 2625–35. doi:10.1093/hmg/ddg283. PMID 12928483.
  • Sauter ER, Lininger J, Magklara A, Hewett JE, Diamandis EP (Feb 2004). "Association of kallikrein expression in nipple aspirate fluid with breast cancer risk". International Journal of Cancer. 108 (4): 588–91. doi:10.1002/ijc.11607. PMID 14696124.
  • Pampalakis G, Kurlender L, Diamandis EP, Sotiropoulou G (Jul 2004). "Cloning and characterization of novel isoforms of the human kallikrein 6 gene". Biochemical and Biophysical Research Communications. 320 (1): 54–61. doi:10.1016/j.bbrc.2004.04.205. PMID 15207701.

External links

  • The MEROPS online database for peptidases and their inhibitors: S01.236
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