KIR2DL4: Difference between revisions

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{{distinguish|NKR2B4}}
{{PBB_Controls
{{Infobox_gene}}
| update_page = yes
'''Killer cell immunoglobulin-like receptor 2DL4''' is a [[protein]] that in humans is encoded by the ''KIR2DL4'' [[gene]].<ref name="pmid8946682">{{cite journal | vauthors = Selvakumar A, Steffens U, Dupont B | title = NK cell receptor gene of the KIR family with two IG domains but highest homology to KIR receptors with three IG domains | journal = Tissue Antigens | volume = 48 | issue = 4 Pt 1 | pages = 285–94 | date=October 1996 | pmid = 8946682 | pmc =  | doi = 10.1111/j.1399-0039.1996.tb02647.x }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: KIR2DL4 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3805| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4
| HGNCid = 6332
| Symbol = KIR2DL4
| AltSymbols =; 103AS; 15.212; CD158D; KIR103; KIR103AS
| OMIM = 604945
| ECnumber = 
| Homologene = 
| MGIid = 
| GeneAtlas_image1 = PBB_GE_KIR2DL4_208426_x_at_tn.png
| GeneAtlas_image2 = PBB_GE_KIR2DL4_211242_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_KIR2DL4_211245_x_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004888 |text = transmembrane receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006968 |text = cellular defense response}} {{GNF_GO|id=GO:0007165 |text = signal transduction}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3805
    | Hs_Ensembl = ENSG00000189013
    | Hs_RefseqProtein = NP_001074239
    | Hs_RefseqmRNA = NM_001080770
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 60006892
    | Hs_GenLoc_end = 60017783
    | Hs_Uniprot = Q99706
    | Mm_EntrezGene = 
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = 
    | Mm_RefseqProtein = 
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4''', also known as '''KIR2DL4''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: KIR2DL4 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3805| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
[[Killer cell immunoglobulin-like receptors]] (KIRs) are transmembrane glycoproteins expressed by [[natural killer cells]] and subsets of [[CD8+ T cells]].<ref name="pmid18334671">{{cite journal | vauthors = Carosella ED, Favier B, Rouas-Freiss N, Moreau P, Lemaoult J | title = Beyond the increasing complexity of the immunomodulatory HLA-G molecule | journal = Blood | volume = 111 | issue = 10 | pages = 4862–70  | date = May 2008 | pmid = 18334671 | pmc =  | doi = 10.1182/blood-2007-12-127662 }}</ref> The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb [[leukocyte receptor complex]] (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the "framework" loci that is present on all haplotypes. Alternative splicing results in multiple transcript variants.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several &quot;framework&quot; genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the &quot;framework&quot; loci that is present on all haplotypes. Alternative splicing results in multiple transcript variants.<ref name="entrez">{{cite web | title = Entrez Gene: KIR2DL4 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3805| accessdate = }}</ref>
}}


==See also==
The only so far reported ligand of KIR2DL4 is the non-classical HLA class 1 gene HLA-G, leading to the inhibition of the cytolytic NK cell function.<ref name="pmid18334671"/>
 
== See also ==
* [[Cluster of differentiation]]
* [[Cluster of differentiation]]


==References==
== References ==
{{reflist|2}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Selvakumar A, Steffens U, Dupont B | title = Polymorphism and domain variability of human killer cell inhibitory receptors | journal = Immunol. Rev. | volume = 155 | issue =  | pages = 183–96 | year = 1997 | pmid = 9059894 | doi = 10.1111/j.1600-065X.1997.tb00951.x }}
| citations =
* {{cite journal | vauthors = Selvakumar A, Steffens U, Palanisamy N, Chaganti RS, Dupont B | title = Genomic organization and allelic polymorphism of the human killer cell inhibitory receptor gene KIR103 | journal = Tissue Antigens | volume = 49 | issue = 6 | pages = 564–73 | year = 1997 | pmid = 9234477 | doi = 10.1111/j.1399-0039.1997.tb02803.x }}
*{{cite journal | author=Selvakumar A, Steffens U, Dupont B |title=Polymorphism and domain variability of human killer cell inhibitory receptors. |journal=Immunol. Rev. |volume=155 |issue=  |pages= 183-96 |year= 1997 |pmid= 9059894 |doi= }}
* {{cite journal | vauthors = Valiante NM, Uhrberg M, Shilling HG, Lienert-Weidenbach K, Arnett KL, D'Andrea A, Phillips JH, Lanier LL, Parham P | title = Functionally and structurally distinct NK cell receptor repertoires in the peripheral blood of two human donors | journal = Immunity | volume = 7 | issue = 6 | pages = 739–51 | year = 1997 | pmid = 9430220 | doi = 10.1016/S1074-7613(00)80393-3 }}
*{{cite journal  | author=Selvakumar A, Steffens U, Dupont B |title=NK cell receptor gene of the KIR family with two IG domains but highest homology to KIR receptors with three IG domains. |journal=Tissue Antigens |volume=48 |issue= 4 Pt 1 |pages= 285-94 |year= 1997 |pmid= 8946682 |doi=  }}
* {{cite journal | vauthors = Uhrberg M, Valiante NM, Shum BP, Shilling HG, Lienert-Weidenbach K, Corliss B, Tyan D, Lanier LL, Parham P | title = Human diversity in killer cell inhibitory receptor genes | journal = Immunity | volume = 7 | issue = 6 | pages = 753–63 | year = 1997 | pmid = 9430221 | doi = 10.1016/S1074-7613(00)80394-5 }}
*{{cite journal | author=Selvakumar A, Steffens U, Palanisamy N, ''et al.'' |title=Genomic organization and allelic polymorphism of the human killer cell inhibitory receptor gene KIR103. |journal=Tissue Antigens |volume=49 |issue= 6 |pages= 564-73 |year= 1997 |pmid= 9234477 |doi= }}
* {{cite journal | vauthors = Rajagopalan S, Long EO | title = A human histocompatibility leukocyte antigen (HLA)-G-specific receptor expressed on all natural killer cells | journal = J. Exp. Med. | volume = 189 | issue = 7 | pages = 1093–100 | year = 1999 | pmid = 10190900 | pmc = 2193010 | doi = 10.1084/jem.189.7.1093 }}
*{{cite journal | author=Valiante NM, Uhrberg M, Shilling HG, ''et al.'' |title=Functionally and structurally distinct NK cell receptor repertoires in the peripheral blood of two human donors. |journal=Immunity |volume=7 |issue= 6 |pages= 739-51 |year= 1998 |pmid= 9430220 |doi= }}
* {{cite journal | vauthors = Rajalingam R, Gardiner CM, Canavez F, Vilches C, Parham P | title = Identification of seventeen novel KIR variants: fourteen of them from two non-Caucasian donors | journal = Tissue Antigens | volume = 57 | issue = 1 | pages = 22–31 | year = 2001 | pmid = 11169255 | doi = 10.1034/j.1399-0039.2001.057001022.x }}
*{{cite journal | author=Uhrberg M, Valiante NM, Shum BP, ''et al.'' |title=Human diversity in killer cell inhibitory receptor genes. |journal=Immunity |volume=7 |issue= 6 |pages= 753-63 |year= 1998 |pmid= 9430221 |doi= }}
* {{cite journal | vauthors = Rajagopalan S, Fu J, Long EO | title = Cutting edge: induction of IFN-gamma production but not cytotoxicity by the killer cell Ig-like receptor KIR2DL4 (CD158d) in resting NK cells | journal = J. Immunol. | volume = 167 | issue = 4 | pages = 1877–81 | year = 2001 | pmid = 11489965 | doi = 10.4049/jimmunol.167.4.1877 }}
*{{cite journal | author=Rajagopalan S, Long EO |title=A human histocompatibility leukocyte antigen (HLA)-G-specific receptor expressed on all natural killer cells. |journal=J. Exp. Med. |volume=189 |issue= 7 |pages= 1093-100 |year= 1999 |pmid= 10190900 |doi= }}
* {{cite journal | vauthors = Witt CS, Whiteway JM, Warren HS, Barden A, Rogers M, Martin A, Beilin L, Christiansen FT | title = Alleles of the KIR2DL4 receptor and their lack of association with pre-eclampsia | journal = Eur. J. Immunol. | volume = 32 | issue = 1 | pages = 18–29 | year = 2002 | pmid = 11754000 | doi = 10.1002/1521-4141(200201)32:1<18::AID-IMMU18>3.0.CO;2-7 }}
*{{cite journal | author=Rajalingam R, Gardiner CM, Canavez F, ''et al.'' |title=Identification of seventeen novel KIR variants: fourteen of them from two non-Caucasian donors. |journal=Tissue Antigens |volume=57 |issue= 1 |pages= 22-31 |year= 2001 |pmid= 11169255 |doi= }}
* {{cite journal | vauthors = Yusa S, Catina TL, Campbell KS | title = SHP-1- and phosphotyrosine-independent inhibitory signaling by a killer cell Ig-like receptor cytoplasmic domain in human NK cells | journal = J. Immunol. | volume = 168 | issue = 10 | pages = 5047–57 | year = 2002 | pmid = 11994457 | doi = 10.4049/jimmunol.168.10.5047 }}
*{{cite journal | author=Rajagopalan S, Fu J, Long EO |title=Cutting edge: induction of IFN-gamma production but not cytotoxicity by the killer cell Ig-like receptor KIR2DL4 (CD158d) in resting NK cells. |journal=J. Immunol. |volume=167 |issue= 4 |pages= 1877-81 |year= 2001 |pmid= 11489965 |doi= }}
* {{cite journal | vauthors = Faure M, Long EO | title = KIR2DL4 (CD158d), an NK cell-activating receptor with inhibitory potential | journal = J. Immunol. | volume = 168 | issue = 12 | pages = 6208–14 | year = 2002 | pmid = 12055234 | doi = 10.4049/jimmunol.168.12.6208 }}
*{{cite journal | author=Witt CS, Whiteway JM, Warren HS, ''et al.'' |title=Alleles of the KIR2DL4 receptor and their lack of association with pre-eclampsia. |journal=Eur. J. Immunol. |volume=32 |issue= 1 |pages= 18-29 |year= 2002 |pmid= 11754000 |doi= }}
* {{cite journal | vauthors = Santourlidis S, Trompeter HI, Weinhold S, Eisermann B, Meyer KL, Wernet P, Uhrberg M | title = Crucial role of DNA methylation in determination of clonally distributed killer cell Ig-like receptor expression patterns in NK cells | journal = J. Immunol. | volume = 169 | issue = 8 | pages = 4253–61 | year = 2002 | pmid = 12370356 | doi = 10.4049/jimmunol.169.8.4253 }}
*{{cite journal | author=Yusa S, Catina TL, Campbell KS |title=SHP-1- and phosphotyrosine-independent inhibitory signaling by a killer cell Ig-like receptor cytoplasmic domain in human NK cells. |journal=J. Immunol. |volume=168 |issue= 10 |pages= 5047-57 |year= 2002 |pmid= 11994457 |doi= }}
* {{cite journal | vauthors = Chan HW, Kurago ZB, Stewart CA, Wilson MJ, Martin MP, Mace BE, Carrington M, Trowsdale J, Lutz CT | title = DNA methylation maintains allele-specific KIR gene expression in human natural killer cells | journal = J. Exp. Med. | volume = 197 | issue = 2 | pages = 245–55 | year = 2003 | pmid = 12538663 | pmc = 2193817 | doi = 10.1084/jem.20021127 }}
*{{cite journal | author=Faure M, Long EO |title=KIR2DL4 (CD158d), an NK cell-activating receptor with inhibitory potential. |journal=J. Immunol. |volume=168 |issue= 12 |pages= 6208-14 |year= 2002 |pmid= 12055234 |doi= }}
* {{cite journal | vauthors = Becker S, Tonn T, Füssel T, Uhrberg M, Bogdanow M, Seifried E, Seidl C | title = Assessment of killer cell immunoglobulinlike receptor expression and corresponding HLA class I phenotypes demonstrates heterogenous KIR expression independent of anticipated HLA class I ligands | journal = Hum. Immunol. | volume = 64 | issue = 2 | pages = 183–93 | year = 2003 | pmid = 12559621 | doi = 10.1016/S0198-8859(02)00802-9 }}
*{{cite journal | author=Santourlidis S, Trompeter HI, Weinhold S, ''et al.'' |title=Crucial role of DNA methylation in determination of clonally distributed killer cell Ig-like receptor expression patterns in NK cells. |journal=J. Immunol. |volume=169 |issue= 8 |pages= 4253-61 |year= 2002 |pmid= 12370356 |doi= }}
* {{cite journal | vauthors = Gómez-Lozano N, de Pablo R, Puente S, Vilches C | title = Recognition of HLA-G by the NK cell receptor KIR2DL4 is not essential for human reproduction | journal = Eur. J. Immunol. | volume = 33 | issue = 3 | pages = 639–44 | year = 2003 | pmid = 12616484 | doi = 10.1002/eji.200323741 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Stewart CA, Van Bergen J, Trowsdale J | title = Different and divergent regulation of the KIR2DL4 and KIR3DL1 promoters | journal = J. Immunol. | volume = 170 | issue = 12 | pages = 6073–81 | year = 2003 | pmid = 12794136 | doi = 10.4049/jimmunol.170.12.6073 }}
*{{cite journal | author=Chan HW, Kurago ZB, Stewart CA, ''et al.'' |title=DNA methylation maintains allele-specific KIR gene expression in human natural killer cells. |journal=J. Exp. Med. |volume=197 |issue= 2 |pages= 245-55 |year= 2003 |pmid= 12538663 |doi= }}
* {{cite journal | vauthors = Williams F, Maxwell LD, Halfpenny IA, Meenagh A, Sleator C, Curran MD, Middleton D | title = Multiple copies of KIR 3DL/S1 and KIR 2DL4 genes identified in a number of individuals | journal = Hum. Immunol. | volume = 64 | issue = 7 | pages = 729–32 | year = 2003 | pmid = 12826375 | doi = 10.1016/S0198-8859(03)00089-2 }}
*{{cite journal | author=Becker S, Tonn T, Füssel T, ''et al.'' |title=Assessment of killer cell immunoglobulinlike receptor expression and corresponding HLA class I phenotypes demonstrates heterogenous KIR expression independent of anticipated HLA class I ligands. |journal=Hum. Immunol. |volume=64 |issue= 2 |pages= 183-93 |year= 2003 |pmid= 12559621 |doi= }}
* {{cite journal | vauthors = Goodridge JP, Witt CS, Christiansen FT, Warren HS | title = KIR2DL4 (CD158d) genotype influences expression and function in NK cells | journal = J. Immunol. | volume = 171 | issue = 4 | pages = 1768–74 | year = 2003 | pmid = 12902476 | doi = 10.4049/jimmunol.171.4.1768 }}
*{{cite journal | author=Gómez-Lozano N, de Pablo R, Puente S, Vilches C |title=Recognition of HLA-G by the NK cell receptor KIR2DL4 is not essential for human reproduction. |journal=Eur. J. Immunol. |volume=33 |issue= 3 |pages= 639-44 |year= 2003 |pmid= 12616484 |doi= 10.1002/eji.200323741 }}
*{{cite journal | author=Stewart CA, Van Bergen J, Trowsdale J |title=Different and divergent regulation of the KIR2DL4 and KIR3DL1 promoters. |journal=J. Immunol. |volume=170 |issue= 12 |pages= 6073-81 |year= 2003 |pmid= 12794136 |doi= }}
*{{cite journal | author=Williams F, Maxwell LD, Halfpenny IA, ''et al.'' |title=Multiple copies of KIR 3DL/S1 and KIR 2DL4 genes identified in a number of individuals. |journal=Hum. Immunol. |volume=64 |issue= 7 |pages= 729-32 |year= 2004 |pmid= 12826375 |doi= }}
*{{cite journal | author=Goodridge JP, Witt CS, Christiansen FT, Warren HS |title=KIR2DL4 (CD158d) genotype influences expression and function in NK cells. |journal=J. Immunol. |volume=171 |issue= 4 |pages= 1768-74 |year= 2003 |pmid= 12902476 |doi= }}
}}
{{refend}}
{{refend}}


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Revision as of 01:54, 27 October 2017

Not to be confused with NKR2B4.
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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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Wikidata
View/Edit Human

Killer cell immunoglobulin-like receptor 2DL4 is a protein that in humans is encoded by the KIR2DL4 gene.[1][2]

Function

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of CD8+ T cells.[3] The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the "framework" loci that is present on all haplotypes. Alternative splicing results in multiple transcript variants.[2]

The only so far reported ligand of KIR2DL4 is the non-classical HLA class 1 gene HLA-G, leading to the inhibition of the cytolytic NK cell function.[3]

See also

References

  1. ↑ Selvakumar A, Steffens U, Dupont B (October 1996). "NK cell receptor gene of the KIR family with two IG domains but highest homology to KIR receptors with three IG domains". Tissue Antigens. 48 (4 Pt 1): 285–94. doi:10.1111/j.1399-0039.1996.tb02647.x. PMID 8946682.
  2. ↑ 2.0 2.1 "Entrez Gene: KIR2DL4 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4".
  3. ↑ 3.0 3.1 Carosella ED, Favier B, Rouas-Freiss N, Moreau P, Lemaoult J (May 2008). "Beyond the increasing complexity of the immunomodulatory HLA-G molecule". Blood. 111 (10): 4862–70. doi:10.1182/blood-2007-12-127662. PMID 18334671.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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