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'''Far upstream element-binding protein 2''' is a [[protein]] that in humans is encoded by the ''KHSRP'' [[gene]].<ref name="pmid9136930">{{cite journal |vauthors=Min H, Turck CW, Nikolic JM, Black DL | title = A new regulatory protein, KSRP, mediates exon inclusion through an intronic splicing enhancer | journal = Genes Dev | volume = 11 | issue = 8 | pages = 1023–36 |date=May 1997 | pmid = 9136930 | pmc = | doi =10.1101/gad.11.8.1023 }}</ref><ref name="pmid8940189">{{cite journal |vauthors=Davis-Smyth T, Duncan RC, Zheng T, Michelotti G, Levens D | title = The far upstream element-binding proteins comprise an ancient family of single-strand DNA-binding transactivators | journal = J Biol Chem | volume = 271 | issue = 49 | pages = 31679–87 |date=Jan 1997 | pmid = 8940189 | pmc = | doi =10.1074/jbc.271.49.31679 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: KHSRP KH-type splicing regulatory protein (FUSE binding protein 2)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8570| accessdate = }}</ref> | |||
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==References== | ==References== | ||
{{reflist | {{reflist}} | ||
==Further reading== | ==Further reading== | ||
{{refbegin | 2}} | {{refbegin | 2}} | ||
{{PBB_Further_reading | {{PBB_Further_reading | ||
| citations = | | citations = | ||
*{{cite journal | | *{{cite journal |vauthors=Dawson SJ, White LA |title=Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin. |journal=J. Infect. |volume=24 |issue= 3 |pages= 317–20 |year= 1992 |pmid= 1602151 |doi=10.1016/S0163-4453(05)80037-4 }} | ||
*{{cite journal | | *{{cite journal |vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 }} | ||
*{{cite journal | | *{{cite journal |vauthors=Chou MY, Rooke N, Turck CW, Black DL |title=hnRNP H is a component of a splicing enhancer complex that activates a c-src alternative exon in neuronal cells. |journal=Mol. Cell. Biol. |volume=19 |issue= 1 |pages= 69–77 |year= 1999 |pmid= 9858532 |doi= | pmc=83866 }} | ||
*{{cite journal | *{{cite journal |vauthors=Ring HZ, Vameghi-Meyers V, Nikolic JM, etal |title=Mapping of the KHSRP gene to a region of conserved synteny on human chromosome 19p13.3 and mouse chromosome 17. |journal=Genomics |volume=56 |issue= 3 |pages= 350–2 |year= 1999 |pmid= 10087204 |doi= 10.1006/geno.1998.5725 }} | ||
*{{cite journal | *{{cite journal |vauthors=Lellek H, Kirsten R, Diehl I, etal |title=Purification and molecular cloning of a novel essential component of the apolipoprotein B mRNA editing enzyme-complex. |journal=J. Biol. Chem. |volume=275 |issue= 26 |pages= 19848–56 |year= 2000 |pmid= 10781591 |doi= 10.1074/jbc.M001786200 }} | ||
*{{cite journal | *{{cite journal |vauthors=Chou MY, Underwood JG, Nikolic J, etal |title=Multisite RNA binding and release of polypyrimidine tract binding protein during the regulation of c-src neural-specific splicing. |journal=Mol. Cell |volume=5 |issue= 6 |pages= 949–57 |year= 2000 |pmid= 10911989 |doi=10.1016/S1097-2765(00)80260-9 }} | ||
*{{cite journal | *{{cite journal |vauthors=Markovtsov V, Nikolic JM, Goldman JA, etal |title=Cooperative assembly of an hnRNP complex induced by a tissue-specific homolog of polypyrimidine tract binding protein. |journal=Mol. Cell. Biol. |volume=20 |issue= 20 |pages= 7463–79 |year= 2000 |pmid= 11003644 |doi=10.1128/MCB.20.20.7463-7479.2000 | pmc=86300 }} | ||
*{{cite journal | *{{cite journal |vauthors=Chen CY, Gherzi R, Ong SE, etal |title=AU binding proteins recruit the exosome to degrade ARE-containing mRNAs. |journal=Cell |volume=107 |issue= 4 |pages= 451–64 |year= 2002 |pmid= 11719186 |doi=10.1016/S0092-8674(01)00578-5 }} | ||
*{{cite journal | *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }} | ||
*{{cite journal | | *{{cite journal |vauthors=Hall MP, Huang S, Black DL |title=Differentiation-induced colocalization of the KH-type splicing regulatory protein with polypyrimidine tract binding protein and the c-src pre-mRNA. |journal=Mol. Biol. Cell |volume=15 |issue= 2 |pages= 774–86 |year= 2004 |pmid= 14657238 |doi= 10.1091/mbc.E03-09-0692 | pmc=329392 }} | ||
*{{cite journal |vauthors=Gherzi R, Lee KY, Briata P, etal |title=A KH domain RNA binding protein, KSRP, promotes ARE-directed mRNA turnover by recruiting the degradation machinery. |journal=Mol. Cell |volume=14 |issue= 5 |pages= 571–83 |year= 2004 |pmid= 15175153 |doi= 10.1016/j.molcel.2004.05.002 }} | |||
*{{cite journal | *{{cite journal |vauthors=Suswam EA, Nabors LB, Huang Y, etal |title=IL-1beta induces stabilization of IL-8 mRNA in malignant breast cancer cells via the 3' untranslated region: Involvement of divergent RNA-binding factors HuR, KSRP and TIAR. |journal=Int. J. Cancer |volume=113 |issue= 6 |pages= 911–9 |year= 2005 |pmid= 15514971 |doi= 10.1002/ijc.20675 }} | ||
*{{cite journal | *{{cite journal |vauthors=Wickham L, Benjannet S, Marcinkiewicz E, etal |title=Beta-amyloid protein converting enzyme 1 and brain-specific type II membrane protein BRI3: binding partners processed by furin. |journal=J. Neurochem. |volume=92 |issue= 1 |pages= 93–102 |year= 2005 |pmid= 15606899 |doi= 10.1111/j.1471-4159.2004.02840.x }} | ||
*{{cite journal | *{{cite journal |vauthors=Chou CF, Mulky A, Maitra S, etal |title=Tethering KSRP, a decay-promoting AU-rich element-binding protein, to mRNAs elicits mRNA decay. |journal=Mol. Cell. Biol. |volume=26 |issue= 10 |pages= 3695–706 |year= 2006 |pmid= 16648466 |doi= 10.1128/MCB.26.10.3695-3706.2006 | pmc=1489004 }} | ||
*{{cite journal | *{{cite journal |vauthors=Beausoleil SA, Villén J, Gerber SA, etal |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285–92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 }} | ||
*{{cite journal | *{{cite journal |vauthors=Olsen JV, Blagoev B, Gnad F, etal |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }} | ||
*{{cite journal | *{{cite journal |vauthors=Gherzi R, Trabucchi M, Ponassi M, etal |title=The RNA-binding protein KSRP promotes decay of beta-catenin mRNA and is inactivated by PI3K-AKT signaling. |journal=PLoS Biol. |volume=5 |issue= 1 |pages= e5 |year= 2007 |pmid= 17177604 |doi= 10.1371/journal.pbio.0050005 | pmc=1702562 }} | ||
*{{cite journal | *{{cite journal |vauthors=Ewing RM, Chu P, Elisma F, etal |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= 1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 | pmc=1847948 }} | ||
}} | }} | ||
{{refend}} | {{refend}} | ||
{{PDB Gallery|geneid=8570}} | |||
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| External IDs | GeneCards: [1] | ||||||
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| Location (UCSC) | n/a | n/a | |||||
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Far upstream element-binding protein 2 is a protein that in humans is encoded by the KHSRP gene.[1][2][3]
References
- ↑ Min H, Turck CW, Nikolic JM, Black DL (May 1997). "A new regulatory protein, KSRP, mediates exon inclusion through an intronic splicing enhancer". Genes Dev. 11 (8): 1023–36. doi:10.1101/gad.11.8.1023. PMID 9136930.
- ↑ Davis-Smyth T, Duncan RC, Zheng T, Michelotti G, Levens D (Jan 1997). "The far upstream element-binding proteins comprise an ancient family of single-strand DNA-binding transactivators". J Biol Chem. 271 (49): 31679–87. doi:10.1074/jbc.271.49.31679. PMID 8940189.
- ↑ "Entrez Gene: KHSRP KH-type splicing regulatory protein (FUSE binding protein 2)".
Further reading
- Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin". J. Infect. 24 (3): 317–20. doi:10.1016/S0163-4453(05)80037-4. PMID 1602151.
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
- Chou MY, Rooke N, Turck CW, Black DL (1999). "hnRNP H is a component of a splicing enhancer complex that activates a c-src alternative exon in neuronal cells". Mol. Cell. Biol. 19 (1): 69–77. PMC 83866. PMID 9858532.
- Ring HZ, Vameghi-Meyers V, Nikolic JM, et al. (1999). "Mapping of the KHSRP gene to a region of conserved synteny on human chromosome 19p13.3 and mouse chromosome 17". Genomics. 56 (3): 350–2. doi:10.1006/geno.1998.5725. PMID 10087204.
- Lellek H, Kirsten R, Diehl I, et al. (2000). "Purification and molecular cloning of a novel essential component of the apolipoprotein B mRNA editing enzyme-complex". J. Biol. Chem. 275 (26): 19848–56. doi:10.1074/jbc.M001786200. PMID 10781591.
- Chou MY, Underwood JG, Nikolic J, et al. (2000). "Multisite RNA binding and release of polypyrimidine tract binding protein during the regulation of c-src neural-specific splicing". Mol. Cell. 5 (6): 949–57. doi:10.1016/S1097-2765(00)80260-9. PMID 10911989.
- Markovtsov V, Nikolic JM, Goldman JA, et al. (2000). "Cooperative assembly of an hnRNP complex induced by a tissue-specific homolog of polypyrimidine tract binding protein". Mol. Cell. Biol. 20 (20): 7463–79. doi:10.1128/MCB.20.20.7463-7479.2000. PMC 86300. PMID 11003644.
- Chen CY, Gherzi R, Ong SE, et al. (2002). "AU binding proteins recruit the exosome to degrade ARE-containing mRNAs". Cell. 107 (4): 451–64. doi:10.1016/S0092-8674(01)00578-5. PMID 11719186.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Hall MP, Huang S, Black DL (2004). "Differentiation-induced colocalization of the KH-type splicing regulatory protein with polypyrimidine tract binding protein and the c-src pre-mRNA". Mol. Biol. Cell. 15 (2): 774–86. doi:10.1091/mbc.E03-09-0692. PMC 329392. PMID 14657238.
- Gherzi R, Lee KY, Briata P, et al. (2004). "A KH domain RNA binding protein, KSRP, promotes ARE-directed mRNA turnover by recruiting the degradation machinery". Mol. Cell. 14 (5): 571–83. doi:10.1016/j.molcel.2004.05.002. PMID 15175153.
- Suswam EA, Nabors LB, Huang Y, et al. (2005). "IL-1beta induces stabilization of IL-8 mRNA in malignant breast cancer cells via the 3' untranslated region: Involvement of divergent RNA-binding factors HuR, KSRP and TIAR". Int. J. Cancer. 113 (6): 911–9. doi:10.1002/ijc.20675. PMID 15514971.
- Wickham L, Benjannet S, Marcinkiewicz E, et al. (2005). "Beta-amyloid protein converting enzyme 1 and brain-specific type II membrane protein BRI3: binding partners processed by furin". J. Neurochem. 92 (1): 93–102. doi:10.1111/j.1471-4159.2004.02840.x. PMID 15606899.
- Chou CF, Mulky A, Maitra S, et al. (2006). "Tethering KSRP, a decay-promoting AU-rich element-binding protein, to mRNAs elicits mRNA decay". Mol. Cell. Biol. 26 (10): 3695–706. doi:10.1128/MCB.26.10.3695-3706.2006. PMC 1489004. PMID 16648466.
- Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
- Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
- Gherzi R, Trabucchi M, Ponassi M, et al. (2007). "The RNA-binding protein KSRP promotes decay of beta-catenin mRNA and is inactivated by PI3K-AKT signaling". PLoS Biol. 5 (1): e5. doi:10.1371/journal.pbio.0050005. PMC 1702562. PMID 17177604.
- Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
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