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==Overview==
==Overview==

Revision as of 20:09, 7 February 2018

Jaundice Microchapters

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Fatima Shaukat, MD [2]

Overview

Jaundice is classified in two categories: Unconjugated hyperbilirubinemia and combined conjugated and unconjugated hyperbilirubinema. Unconjugated hypebilirubinemia can be caused by eiether increased production, reduced reuptake or defects in conjugation. While combined conjugated and unconjugated hyperbilirubinemia is further classified into: Obstruction of biliary tract, Interahepatic cholestasis, injury to hepatocellular parenchyma and defects of hepatocellular canalicular excretion or re-uptake in sinusoids

Classification

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Jaundice classification
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Conjugated and unconjugated hyperbilirubenemia
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Unconjugated hyperbilirubinemia
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Obstruction of biliary tract
 
Intra-hepatic cholestasis
 
 
 
Injury to hepatocellular parenchyma
 
 
 
Defects of hepatocellular canalicular excretion or re-uptake in sinusoids
 
Increased production
 
Reduced uptake
 
 
 
Defects in conjugation
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Acute
 
Chronic
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Acquired
 
Inherited
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
• Primary billiary cholangitis
Primary sclerosing cholangitis
Viral hepatitis (ocassionally)
Progressive familial intrahepatic cholestasis
Intrahepatic Cholestasis of Pregnancy
Corticosteroids
 
 
 
 
 
 
 
 
 
Dubin-Johnson syndrome
Rotor syndrome
 

Hemolysis
Wilson disease
• Extravasation
Shunt hyperbilirubinemia
 
• Portosystemic shunts
Drugs
Gilbert syndrome (some cases)
 

• Neonatal
• Maternal milk
• Lucy-Driscoll
Hyperthyroidism
• Chronic persitent hepatitis
• Advanced cirrhosis
 
Crigler-Najjar syndrome l
Crigler-Najjar syndrome II
Gilbert syndrome
 

References


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