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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
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'''Protein ajuba''' is a [[protein]] that in humans is encoded by the ''JUB'' [[gene]].<ref name="pmid10330178">{{cite journal | vauthors = Goyal RK, Lin P, Kanungo J, Payne AS, Muslin AJ, Longmore GD | title = Ajuba, a Novel LIM Protein, Interacts with Grb2, Augments Mitogen-Activated Protein Kinase Activity in Fibroblasts, and Promotes Meiotic Maturation of Xenopus Oocytes in a Grb2- and Ras-Dependent Manner | journal = Mol Cell Biol | volume = 19 | issue = 6 | pages = 4379–89 | date = Jun 1999 | pmid = 10330178 | pmc = 104397 | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: JUB jub, ajuba homolog (Xenopus laevis)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84962| accessdate = }}</ref>
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| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Jub, ajuba homolog (Xenopus laevis)
| HGNCid = 20250
| Symbol = JUB
| AltSymbols =; Ajuba; MGC15563
| OMIM = 609066
| ECnumber = 
| Homologene = 7789
| MGIid = 1341886
| Function = {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component =
| Process =
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 84962
    | Hs_Ensembl = ENSG00000129474
    | Hs_RefseqProtein = NP_116265
    | Hs_RefseqmRNA = NM_032876
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 14
    | Hs_GenLoc_start = 22510249
    | Hs_GenLoc_end = 22521691
    | Hs_Uniprot = 
    | Mm_EntrezGene = 16475
    | Mm_Ensembl = ENSMUSG00000022178
    | Mm_RefseqmRNA = NM_010590
    | Mm_RefseqProtein = NP_034720
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 14
    | Mm_GenLoc_start = 53523136
    | Mm_GenLoc_end = 53531469
    | Mm_Uniprot = 
  }}
}}
'''Jub, ajuba homolog (Xenopus laevis)''', also known as '''JUB''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: JUB jub, ajuba homolog (Xenopus laevis)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84962| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
JUB proteins contribute to cell fate determination and regulate cell proliferation and differentiation. Plays an important role in regulation of the kinase activity of AURKA/Aurora-A for mitotic commitment.
{{PBB_Summary
| section_title =
| summary_text =
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
JUB (gene) has been shown to [[Protein-protein interaction|interact]] with [[Stratifin]]<ref name=pmid15778465>{{cite journal | vauthors = Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H | title = Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer | journal = Mol. Cell. Proteomics | volume = 4 | issue = 6 | pages = 785–95 | date = Jun 2005 | pmid = 15778465 | doi = 10.1074/mcp.M500021-MCP200 }}</ref> and [[SLC1A2]].<ref name=pmid11860269>{{cite journal | vauthors = Marie H, Billups D, Bedford FK, Dumoulin A, Goyal RK, Longmore GD, Moss SJ, Attwell D | title = The amino terminus of the glial glutamate transporter GLT-1 interacts with the LIM protein Ajuba | journal = Mol. Cell. Neurosci. | volume = 19 | issue = 2 | pages = 152–64 | date = Feb 2002 | pmid = 11860269 | doi = 10.1006/mcne.2001.1066 }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Kanungo J, Pratt SJ, Marie H, Longmore GD | title = Ajuba, a Cytosolic LIM Protein, Shuttles into the Nucleus and Affects Embryonal Cell Proliferation and Fate Decisions | journal = Mol. Biol. Cell | volume = 11 | issue = 10 | pages = 3299–313 | year = 2000 | pmid = 11029037 | pmc = 14993 | doi = 10.1091/mbc.11.10.3299 }}
| citations =
* {{cite journal | vauthors = Marie H, Billups D, Bedford FK, Dumoulin A, Goyal RK, Longmore GD, Moss SJ, Attwell D | title = The amino terminus of the glial glutamate transporter GLT-1 interacts with the LIM protein Ajuba | journal = Mol. Cell. Neurosci. | volume = 19 | issue = 2 | pages = 152–64 | year = 2002 | pmid = 11860269 | doi = 10.1006/mcne.2001.1066 }}
*{{cite journal | author=Goyal RK, Lin P, Kanungo J, ''et al.'' |title=Ajuba, a novel LIM protein, interacts with Grb2, augments mitogen-activated protein kinase activity in fibroblasts, and promotes meiotic maturation of Xenopus oocytes in a Grb2- and Ras-dependent manner. |journal=Mol. Cell. Biol. |volume=19 |issue= 6 |pages= 4379-89 |year= 1999 |pmid= 10330178 |doi=  }}
* {{cite journal | vauthors = Marie H, Pratt SJ, Betson M, Epple H, Kittler JT, Meek L, Moss SJ, Troyanovsky S, Attwell D, Longmore GD, Braga VM | title = The LIM protein Ajuba is recruited to cadherin-dependent cell junctions through an association with alpha-catenin | journal = J. Biol. Chem. | volume = 278 | issue = 2 | pages = 1220–8 | year = 2003 | pmid = 12417594 | doi = 10.1074/jbc.M205391200 }}
*{{cite journal  | author=Kanungo J, Pratt SJ, Marie H, Longmore GD |title=Ajuba, a cytosolic LIM protein, shuttles into the nucleus and affects embryonal cell proliferation and fate decisions. |journal=Mol. Biol. Cell |volume=11 |issue= 10 |pages= 3299-313 |year= 2000 |pmid= 11029037 |doi= }}
* {{cite journal | vauthors = Hirota T, Kunitoku N, Sasayama T, Marumoto T, Zhang D, Nitta M, Hatakeyama K, Saya H | title = Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells | journal = Cell | volume = 114 | issue = 5 | pages = 585–98 | year = 2003 | pmid = 13678582 | doi = 10.1016/S0092-8674(03)00642-1 }}
*{{cite journal | author=Marie H, Billups D, Bedford FK, ''et al.'' |title=The amino terminus of the glial glutamate transporter GLT-1 interacts with the LIM protein Ajuba. |journal=Mol. Cell. Neurosci. |volume=19 |issue= 2 |pages= 152-64 |year= 2002 |pmid= 11860269 |doi= 10.1006/mcne.2001.1066 }}
* {{cite journal | vauthors = Pratt SJ, Epple H, Ward M, Feng Y, Braga VM, Longmore GD | title = The LIM protein Ajuba influences p130Cas localization and Rac1 activity during cell migration | journal = J. Cell Biol. | volume = 168 | issue = 5 | pages = 813–24 | year = 2005 | pmid = 15728191 | pmc = 2171823 | doi = 10.1083/jcb.200406083 }}
*{{cite journal | author=Marie H, Pratt SJ, Betson M, ''et al.'' |title=The LIM protein Ajuba is recruited to cadherin-dependent cell junctions through an association with alpha-catenin. |journal=J. Biol. Chem. |volume=278 |issue= 2 |pages= 1220-8 |year= 2003 |pmid= 12417594 |doi= 10.1074/jbc.M205391200 }}
* {{cite journal | vauthors = Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H | title = Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer | journal = Mol. Cell. Proteomics | volume = 4 | issue = 6 | pages = 785–95 | year = 2005 | pmid = 15778465 | doi = 10.1074/mcp.M500021-MCP200 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Kisseleva M, Feng Y, Ward M, Song C, Anderson RA, Longmore GD | title = The LIM Protein Ajuba Regulates Phosphatidylinositol 4,5-Bisphosphate Levels in Migrating Cells through an Interaction with and Activation of PIPKIα | journal = Mol. Cell. Biol. | volume = 25 | issue = 10 | pages = 3956–66 | year = 2005 | pmid = 15870270 | pmc = 1087706 | doi = 10.1128/MCB.25.10.3956-3966.2005 }}
*{{cite journal  | author=Hirota T, Kunitoku N, Sasayama T, ''et al.'' |title=Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells. |journal=Cell |volume=114 |issue= 5 |pages= 585-98 |year= 2003 |pmid= 13678582 |doi= }}
* {{cite journal | vauthors = Feng Y, Longmore GD | title = The LIM Protein Ajuba Influences Interleukin-1-Induced NF-κB Activation by Affecting the Assembly and Activity of the Protein Kinase Cζ/p62/TRAF6 Signaling Complex | journal = Mol. Cell. Biol. | volume = 25 | issue = 10 | pages = 4010–22 | year = 2005 | pmid = 15870274 | pmc = 1087715 | doi = 10.1128/MCB.25.10.4010-4022.2005 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
* {{cite journal | vauthors = Abe Y, Ohsugi M, Haraguchi K, Fujimoto J, Yamamoto T | title = LATS2-Ajuba complex regulates gamma-tubulin recruitment to centrosomes and spindle organization during mitosis | journal = FEBS Lett. | volume = 580 | issue = 3 | pages = 782–8 | year = 2006 | pmid = 16413547 | doi = 10.1016/j.febslet.2005.12.096 }}
*{{cite journal | author=Pratt SJ, Epple H, Ward M, ''et al.'' |title=The LIM protein Ajuba influences p130Cas localization and Rac1 activity during cell migration. |journal=J. Cell Biol. |volume=168 |issue= 5 |pages= 813-24 |year= 2005 |pmid= 15728191 |doi= 10.1083/jcb.200406083 }}
* {{cite journal | vauthors = Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY | title = A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration | journal = Cell | volume = 125 | issue = 4 | pages = 801–14 | year = 2006 | pmid = 16713569 | doi = 10.1016/j.cell.2006.03.032 }}
*{{cite journal | author=Benzinger A, Muster N, Koch HB, ''et al.'' |title=Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer. |journal=Mol. Cell Proteomics |volume=4 |issue= 6 |pages= 785-95 |year= 2005 |pmid= 15778465 |doi= 10.1074/mcp.M500021-MCP200 }}
* {{cite journal | vauthors = Alagaratnam S, Hardy JR, Lothe RA, Skotheim RI, Byrne JA | title = TPD52, a candidate gene from genomic studies, is overexpressed in testicular germ cell tumours | journal = Mol. Cell. Endocrinol. | volume = 306 | issue = 1–2 | pages = 75–80 | year = 2008 | pmid = 19041365 | doi = 10.1016/j.mce.2008.10.043 }}
*{{cite journal | author=Kisseleva M, Feng Y, Ward M, ''et al.'' |title=The LIM protein Ajuba regulates phosphatidylinositol 4,5-bisphosphate levels in migrating cells through an interaction with and activation of PIPKI alpha. |journal=Mol. Cell. Biol. |volume=25 |issue= 10 |pages= 3956-66 |year= 2005 |pmid= 15870270 |doi= 10.1128/MCB.25.10.3956-3966.2005 }}
*{{cite journal | author=Feng Y, Longmore GD |title=The LIM protein Ajuba influences interleukin-1-induced NF-kappaB activation by affecting the assembly and activity of the protein kinase Czeta/p62/TRAF6 signaling complex. |journal=Mol. Cell. Biol. |volume=25 |issue= 10 |pages= 4010-22 |year= 2005 |pmid= 15870274 |doi= 10.1128/MCB.25.10.4010-4022.2005 }}
*{{cite journal | author=Abe Y, Ohsugi M, Haraguchi K, ''et al.'' |title=LATS2-Ajuba complex regulates gamma-tubulin recruitment to centrosomes and spindle organization during mitosis. |journal=FEBS Lett. |volume=580 |issue= 3 |pages= 782-8 |year= 2006 |pmid= 16413547 |doi= 10.1016/j.febslet.2005.12.096 }}
*{{cite journal | author=Lim J, Hao T, Shaw C, ''et al.'' |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801-14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 }}
}}
{{refend}}
{{refend}}


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Latest revision as of 06:27, 10 January 2019

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Protein ajuba is a protein that in humans is encoded by the JUB gene.[1][2]

Function

JUB proteins contribute to cell fate determination and regulate cell proliferation and differentiation. Plays an important role in regulation of the kinase activity of AURKA/Aurora-A for mitotic commitment.

Interactions

JUB (gene) has been shown to interact with Stratifin[3] and SLC1A2.[4]

References

  1. ↑ Goyal RK, Lin P, Kanungo J, Payne AS, Muslin AJ, Longmore GD (Jun 1999). "Ajuba, a Novel LIM Protein, Interacts with Grb2, Augments Mitogen-Activated Protein Kinase Activity in Fibroblasts, and Promotes Meiotic Maturation of Xenopus Oocytes in a Grb2- and Ras-Dependent Manner". Mol Cell Biol. 19 (6): 4379–89. PMC 104397. PMID 10330178.
  2. ↑ "Entrez Gene: JUB jub, ajuba homolog (Xenopus laevis)".
  3. ↑ Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H (Jun 2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Mol. Cell. Proteomics. 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.
  4. ↑ Marie H, Billups D, Bedford FK, Dumoulin A, Goyal RK, Longmore GD, Moss SJ, Attwell D (Feb 2002). "The amino terminus of the glial glutamate transporter GLT-1 interacts with the LIM protein Ajuba". Mol. Cell. Neurosci. 19 (2): 152–64. doi:10.1006/mcne.2001.1066. PMID 11860269.

Further reading


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