ITIH2: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Inter-alpha-trypsin inhibitor heavy chain H2''' is a [[protein]] that in humans is encoded by the ''ITIH2'' [[gene]].<ref name="pmid1385302">{{cite journal |vauthors=Salier JP, Simon D, Rouet P, Raguenez G, Muscatelli F, Gebhard W, Guenet JL, Mattei MG | title = Homologous chromosomal locations of the four genes for inter-alpha-inhibitor and pre-alpha-inhibitor family in human and mouse: assignment of the ancestral gene for the lipocalin superfamily | journal = Genomics | volume = 14 | issue = 1 | pages = 83–8 |date=Dec 1992 | pmid = 1385302 | pmc =  | doi =10.1016/S0888-7543(05)80287-3  }}</ref><ref name="pmid10100603">{{cite journal |vauthors=Jean L, Risler JL, Nagase T, Coulouarn C, Nomura N, Salier JP | title = The nuclear protein PH5P of the inter-alpha-inhibitor superfamily: a missing link between poly(ADP-ribose)polymerase and the inter-alpha-inhibitor family and a novel actor of DNA repair? | journal = FEBS Lett | volume = 446 | issue = 1 | pages = 6–8 |date=May 1999 | pmid = 10100603 | pmc = | doi =10.1016/S0014-5793(99)00173-8  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ITIH2 inter-alpha (globulin) inhibitor H2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3698| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
It is known to contain a [[Gla domain]], and thus be dependent for production on post translational modification requiring [[vitamin K]]. Its function is also presumably dependent on calcium ions.
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Inter-alpha (globulin) inhibitor H2
| HGNCid = 6167
| Symbol = ITIH2
| AltSymbols =; H2P; SHAP
| OMIM = 146640
| ECnumber = 
| Homologene = 1668
| MGIid = 96619
| GeneAtlas_image1 = PBB_GE_ITIH2_204987_at_tn.png
| Function = {{GNF_GO|id=GO:0004867 |text = serine-type endopeptidase inhibitor activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}}
| Process = {{GNF_GO|id=GO:0030212 |text = hyaluronan metabolic process}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3698
    | Hs_Ensembl = ENSG00000151655
    | Hs_RefseqProtein = NP_002207
    | Hs_RefseqmRNA = NM_002216
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 10
    | Hs_GenLoc_start = 7785238
    | Hs_GenLoc_end = 7831489
    | Hs_Uniprot = P19823
    | Mm_EntrezGene = 16425
    | Mm_Ensembl = ENSMUSG00000037254
    | Mm_RefseqmRNA = NM_010582
    | Mm_RefseqProtein = NP_034712
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 10012442
    | Mm_GenLoc_end = 10048516
    | Mm_Uniprot = Q3UZM0
  }}
}}
'''Inter-alpha (globulin) inhibitor H2''', also known as '''ITIH2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ITIH2 inter-alpha (globulin) inhibitor H2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3698| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== See also ==
{{PBB_Summary
* [[Inter-alpha-trypsin inhibitor]]
| section_title =
* [[ITIH1]]
| summary_text =
* [[ITIH3]]
}}
* [[ITIH4]]


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal   |vauthors=Malki N, Balduyck M, Maes P, etal |title=The heavy chains of human plasma inter-alpha-trypsin inhibitor: their isolation, their identification by electrophoresis and partial sequencing. Differential reactivity with concanavalin A. |journal=Biol. Chem. Hoppe-Seyler |volume=373 |issue= 10 |pages= 1009–18 |year= 1992 |pmid= 1384548 |doi=  10.1515/bchm3.1992.373.2.1009}}
| citations =
*{{cite journal   |vauthors=Salier JP, Diarra-Mehrpour M, Sesboue R, etal |title=Isolation and characterization of cDNAs encoding the heavy chain of human inter-alpha-trypsin inhibitor (I alpha TI): unambiguous evidence for multipolypeptide chain structure of I alpha TI. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=84 |issue= 23 |pages= 8272–6 |year= 1988 |pmid= 2446322 |doi=10.1073/pnas.84.23.8272  | pmc=299524  }}
*{{cite journal | author=Jean L, Risler JL, Nagase T, ''et al.'' |title=The nuclear protein PH5P of the inter-alpha-inhibitor superfamily: a missing link between poly(ADP-ribose)polymerase and the inter-alpha-inhibitor family and a novel actor of DNA repair? |journal=FEBS Lett. |volume=446 |issue= 1 |pages= 6-8 |year= 1999 |pmid= 10100603 |doi=  }}
*{{cite journal  |vauthors=Gebhard W, Schreitmüller T, Hochstrasser K, Wachter E |title=Complementary DNA and derived amino acid sequence of the precursor of one of the three protein components of the inter-alpha-trypsin inhibitor complex. |journal=FEBS Lett. |volume=229 |issue= 1 |pages= 63–7 |year= 1988 |pmid= 2450046 |doi=10.1016/0014-5793(88)80798-1  }}
*{{cite journal | author=Malki N, Balduyck M, Maes P, ''et al.'' |title=The heavy chains of human plasma inter-alpha-trypsin inhibitor: their isolation, their identification by electrophoresis and partial sequencing. Differential reactivity with concanavalin A. |journal=Biol. Chem. Hoppe-Seyler |volume=373 |issue= 10 |pages= 1009-18 |year= 1992 |pmid= 1384548 |doi= }}
*{{cite journal   |vauthors=Salier JP, Diarra-Mehrpour M, Sesboüé R, etal |title=Human inter-alpha-trypsin inhibitor. Isolation and characterization of heavy (H) chain cDNA clones coding for a 383 amino-acid sequence of the H chain. |journal=Biol. Chem. Hoppe-Seyler |volume=369 Suppl |issue= |pages= 15–8 |year= 1989 |pmid= 2462430 |doi=  }}
*{{cite journal  | author=Salier JP, Simon D, Rouet P, ''et al.'' |title=Homologous chromosomal locations of the four genes for inter-alpha-inhibitor and pre-alpha-inhibitor family in human and mouse: assignment of the ancestral gene for the lipocalin superfamily. |journal=Genomics |volume=14 |issue= 1 |pages= 83-8 |year= 1992 |pmid= 1385302 |doi= }}
*{{cite journal   |vauthors=Diarra-Mehrpour M, Bourguignon J, Sesboüé R, etal |title=Human plasma inter-alpha-trypsin inhibitor is encoded by four genes on three chromosomes. |journal=Eur. J. Biochem. |volume=179 |issue= 1 |pages= 147–54 |year= 1989 |pmid= 2465147 |doi=10.1111/j.1432-1033.1989.tb14532.x }}
*{{cite journal | author=Salier JP, Diarra-Mehrpour M, Sesboue R, ''et al.'' |title=Isolation and characterization of cDNAs encoding the heavy chain of human inter-alpha-trypsin inhibitor (I alpha TI): unambiguous evidence for multipolypeptide chain structure of I alpha TI. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=84 |issue= 23 |pages= 8272-6 |year= 1988 |pmid= 2446322 |doi=  }}
*{{cite journal  |vauthors=Enghild JJ, Thøgersen IB, Pizzo SV, Salvesen G |title=Analysis of inter-alpha-trypsin inhibitor and a novel trypsin inhibitor, pre-alpha-trypsin inhibitor, from human plasma. Polypeptide chain stoichiometry and assembly by glycan. |journal=J. Biol. Chem. |volume=264 |issue= 27 |pages= 15975–81 |year= 1989 |pmid= 2476436 |doi=  }}
*{{cite journal | author=Gebhard W, Schreitmüller T, Hochstrasser K, Wachter E |title=Complementary DNA and derived amino acid sequence of the precursor of one of the three protein components of the inter-alpha-trypsin inhibitor complex. |journal=FEBS Lett. |volume=229 |issue= 1 |pages= 63-7 |year= 1988 |pmid= 2450046 |doi=  }}
*{{cite journal   |vauthors=Schreitmüller T, Hochstrasser K, Reisinger PW, etal |title=cDNA cloning of human inter-alpha-trypsin inhibitor discloses three different proteins. |journal=Biol. Chem. Hoppe-Seyler |volume=368 |issue= 8 |pages= 963–70 |year= 1987 |pmid= 3663330 |doi=  10.1515/bchm3.1987.368.2.963}}
*{{cite journal  | author=Salier JP, Diarra-Mehrpour M, Sesboüé R, ''et al.'' |title=Human inter-alpha-trypsin inhibitor. Isolation and characterization of heavy (H) chain cDNA clones coding for a 383 amino-acid sequence of the H chain. |journal=Biol. Chem. Hoppe-Seyler |volume=369 Suppl |issue= |pages= 15-8 |year= 1989 |pmid= 2462430 |doi=  }}
*{{cite journal  |vauthors=Huang L, Yoneda M, Kimata K |title=A serum-derived hyaluronan-associated protein (SHAP) is the heavy chain of the inter alpha-trypsin inhibitor. |journal=J. Biol. Chem. |volume=268 |issue= 35 |pages= 26725–30 |year= 1994 |pmid= 7504674 |doi=  }}
*{{cite journal | author=Diarra-Mehrpour M, Bourguignon J, Sesboüé R, ''et al.'' |title=Human plasma inter-alpha-trypsin inhibitor is encoded by four genes on three chromosomes. |journal=Eur. J. Biochem. |volume=179 |issue= 1 |pages= 147-54 |year= 1989 |pmid= 2465147 |doi=  }}
*{{cite journal   |vauthors=Morelle W, Capon C, Balduyck M, etal |title=Chondroitin sulphate covalently cross-links the three polypeptide chains of inter-alpha-trypsin inhibitor. |journal=Eur. J. Biochem. |volume=221 |issue= 2 |pages= 881–8 |year= 1994 |pmid= 7513643 |doi=10.1111/j.1432-1033.1994.tb18803.x }}
*{{cite journal  | author=Enghild JJ, Thøgersen IB, Pizzo SV, Salvesen G |title=Analysis of inter-alpha-trypsin inhibitor and a novel trypsin inhibitor, pre-alpha-trypsin inhibitor, from human plasma. Polypeptide chain stoichiometry and assembly by glycan. |journal=J. Biol. Chem. |volume=264 |issue= 27 |pages= 15975-81 |year= 1989 |pmid= 2476436 |doi=  }}
*{{cite journal  |vauthors=Wisniewski HG, Burgess WH, Oppenheim JD, Vilcek J |title=TSG-6, an arthritis-associated hyaluronan binding protein, forms a stable complex with the serum protein inter-alpha-inhibitor. |journal=Biochemistry |volume=33 |issue= 23 |pages= 7423–9 |year= 1994 |pmid= 7516184 |doi=10.1021/bi00189a049 }}
*{{cite journal | author=Schreitmüller T, Hochstrasser K, Reisinger PW, ''et al.'' |title=cDNA cloning of human inter-alpha-trypsin inhibitor discloses three different proteins. |journal=Biol. Chem. Hoppe-Seyler |volume=368 |issue= 8 |pages= 963-70 |year= 1987 |pmid= 3663330 |doi=  }}
*{{cite journal   |vauthors=Enghild JJ, Salvesen G, Thøgersen IB, etal |title=Presence of the protein-glycosaminoglycan-protein covalent cross-link in the inter-alpha-inhibitor-related proteinase inhibitor heavy chain 2/bikunin. |journal=J. Biol. Chem. |volume=268 |issue= 12 |pages= 8711–6 |year= 1993 |pmid= 7682553 |doi=  }}
*{{cite journal  | author=Huang L, Yoneda M, Kimata K |title=A serum-derived hyaluronan-associated protein (SHAP) is the heavy chain of the inter alpha-trypsin inhibitor. |journal=J. Biol. Chem. |volume=268 |issue= 35 |pages= 26725-30 |year= 1994 |pmid= 7504674 |doi=  }}
*{{cite journal  |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal | author=Morelle W, Capon C, Balduyck M, ''et al.'' |title=Chondroitin sulphate covalently cross-links the three polypeptide chains of inter-alpha-trypsin inhibitor. |journal=Eur. J. Biochem. |volume=221 |issue= 2 |pages= 881-8 |year= 1994 |pmid= 7513643 |doi=  }}
*{{cite journal   |vauthors=Mizon C, Balduyck M, Albani D, etal |title=Development of an enzyme-linked immunosorbent assay for human plasma inter-alpha-trypsin inhibitor (ITI) using specific antibodies against each of the H1 and H2 heavy chains. |journal=J. Immunol. Methods |volume=190 |issue= 1 |pages= 61–70 |year= 1996 |pmid= 8601712 |doi=10.1016/0022-1759(95)00257-X  }}
*{{cite journal  | author=Wisniewski HG, Burgess WH, Oppenheim JD, Vilcek J |title=TSG-6, an arthritis-associated hyaluronan binding protein, forms a stable complex with the serum protein inter-alpha-inhibitor. |journal=Biochemistry |volume=33 |issue= 23 |pages= 7423-9 |year= 1994 |pmid= 7516184 |doi=  }}
*{{cite journal   |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Enghild JJ, Salvesen G, Thøgersen IB, ''et al.'' |title=Presence of the protein-glycosaminoglycan-protein covalent cross-link in the inter-alpha-inhibitor-related proteinase inhibitor heavy chain 2/bikunin. |journal=J. Biol. Chem. |volume=268 |issue= 12 |pages= 8711-6 |year= 1993 |pmid= 7682553 |doi= }}
*{{cite journal   |vauthors=Olsen EH, Rahbek-Nielsen H, Thogersen IB, etal |title=Posttranslational modifications of human inter-alpha-inhibitor: identification of glycans and disulfide bridges in heavy chains 1 and 2. |journal=Biochemistry |volume=37 |issue= 1 |pages= 408–16 |year= 1998 |pmid= 9425062 |doi= 10.1021/bi971137d }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal  |vauthors=Mizushima S, Nii A, Kato K, Uemura A |title=Gene expression of the two heavy chains and one light chain forming the inter-alpha-trypsin-inhibitor in human tissues. |journal=Biol. Pharm. Bull. |volume=21 |issue= 2 |pages= 167–9 |year= 1998 |pmid= 9514613 |doi=  10.1248/bpb.21.167}}
*{{cite journal | author=Mizon C, Balduyck M, Albani D, ''et al.'' |title=Development of an enzyme-linked immunosorbent assay for human plasma inter-alpha-trypsin inhibitor (ITI) using specific antibodies against each of the H1 and H2 heavy chains. |journal=J. Immunol. Methods |volume=190 |issue= 1 |pages= 61-70 |year= 1996 |pmid= 8601712 |doi= }}
*{{cite journal   |vauthors=Flahaut C, Capon C, Balduyck M, etal |title=Glycosylation pattern of human inter-alpha-inhibitor heavy chains. |journal=Biochem. J. |volume=333 |issue= 3|pages= 749–56 |year= 1998 |pmid= 9677337 |doi= | pmc=1219641  }}
*{{cite journal  | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal   |vauthors=Hamm A, Veeck J, Bektas N, etal |title=Frequent expression loss of Inter-alpha-trypsin inhibitor heavy chain (ITIH) genes in multiple human solid tumors: a systematic expression analysis. |journal=BMC Cancer |volume=8 |issue= 25 |year= 2008 |pmid= 18226209 |doi=10.1186/1471-2407-8-25 |pages=25 | pmc=2268946 }}
*{{cite journal | author=Olsen EH, Rahbek-Nielsen H, Thogersen IB, ''et al.'' |title=Posttranslational modifications of human inter-alpha-inhibitor: identification of glycans and disulfide bridges in heavy chains 1 and 2. |journal=Biochemistry |volume=37 |issue= 1 |pages= 408-16 |year= 1998 |pmid= 9425062 |doi= 10.1021/bi971137d }}
*{{cite journal | author=Mizushima S, Nii A, Kato K, Uemura A |title=Gene expression of the two heavy chains and one light chain forming the inter-alpha-trypsin-inhibitor in human tissues. |journal=Biol. Pharm. Bull. |volume=21 |issue= 2 |pages= 167-9 |year= 1998 |pmid= 9514613 |doi= }}
*{{cite journal  | author=Flahaut C, Capon C, Balduyck M, ''et al.'' |title=Glycosylation pattern of human inter-alpha-inhibitor heavy chains. |journal=Biochem. J. |volume=333 ( Pt 3) |issue=  |pages= 749-56 |year= 1998 |pmid= 9677337 |doi=  }}
}}
{{refend}}
{{refend}}


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{{WikiDoc Sources}}
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Latest revision as of 00:11, 1 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

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RefSeq (protein)

n/a

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Inter-alpha-trypsin inhibitor heavy chain H2 is a protein that in humans is encoded by the ITIH2 gene.[1][2][3]

It is known to contain a Gla domain, and thus be dependent for production on post translational modification requiring vitamin K. Its function is also presumably dependent on calcium ions.

See also

References

  1. ↑ Salier JP, Simon D, Rouet P, Raguenez G, Muscatelli F, Gebhard W, Guenet JL, Mattei MG (Dec 1992). "Homologous chromosomal locations of the four genes for inter-alpha-inhibitor and pre-alpha-inhibitor family in human and mouse: assignment of the ancestral gene for the lipocalin superfamily". Genomics. 14 (1): 83–8. doi:10.1016/S0888-7543(05)80287-3. PMID 1385302.
  2. ↑ Jean L, Risler JL, Nagase T, Coulouarn C, Nomura N, Salier JP (May 1999). "The nuclear protein PH5P of the inter-alpha-inhibitor superfamily: a missing link between poly(ADP-ribose)polymerase and the inter-alpha-inhibitor family and a novel actor of DNA repair?". FEBS Lett. 446 (1): 6–8. doi:10.1016/S0014-5793(99)00173-8. PMID 10100603.
  3. ↑ "Entrez Gene: ITIH2 inter-alpha (globulin) inhibitor H2".

Further reading


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