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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Integrin, beta 4''' ('''ITGB4''') also known as '''CD104''' ('''C'''luster of '''D'''ifferentiation 104), is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ITGB4 integrin, beta 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3691| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_ITGB4_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1qg3.
| PDB = {{PDB2|1qg3}}
| Name = Integrin, beta 4
| HGNCid = 6158
| Symbol = ITGB4
| AltSymbols =; CD104
| OMIM = 147557
| ECnumber = 
| Homologene = 179
| MGIid = 96613
| GeneAtlas_image1 = PBB_GE_ITGB4_204990_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_ITGB4_204989_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_ITGB4_211905_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0008305 |text = integrin complex}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007154 |text = cell communication}} {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007160 |text = cell-matrix adhesion}} {{GNF_GO|id=GO:0007229 |text = integrin-mediated signaling pathway}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3691
    | Hs_Ensembl = ENSG00000132470
    | Hs_RefseqProtein = NP_000204
    | Hs_RefseqmRNA = NM_000213
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 17
    | Hs_GenLoc_start = 71229111
    | Hs_GenLoc_end = 71265493
    | Hs_Uniprot = P16144
    | Mm_EntrezGene = 192897
    | Mm_Ensembl = ENSMUSG00000020758
    | Mm_RefseqmRNA = NM_001005607
    | Mm_RefseqProtein = NP_001005607
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 115791069
    | Mm_GenLoc_end = 115824502
    | Mm_Uniprot = 
  }}
}}
'''Integrin, beta 4''' ('''ITGB4''') also known as '''CD104''' ('''C'''luster of '''D'''ifferentiation 104), is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ITGB4 integrin, beta 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3691| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
Integrins are heterodimers composed of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: ITGB4 integrin, beta 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3691| accessdate = }}</ref>
}}


==See also==
== Interactions ==
 
ITGB4 has been shown to [[Protein-protein interaction|interact]] with [[Collagen, type XVII, alpha 1]],<ref name=pmid9500991>{{cite journal | vauthors = Aho S, Uitto J | title = Direct interaction between the intracellular domains of bullous pemphigoid antigen 2 (BP180) and beta 4 integrin, hemidesmosomal components of basal keratinocytes | journal = Biochemical and Biophysical Research Communications | volume = 243 | issue = 3 | pages = 694–9 | date = Feb 1998 | pmid = 9500991 | doi = 10.1006/bbrc.1998.8162 }}</ref><ref name=pmid9660880>{{cite journal | vauthors = Schaapveld RQ, Borradori L, Geerts D, van Leusden MR, Kuikman I, Nievers MG, Niessen CM, Steenbergen RD, Snijders PJ, Sonnenberg A | title = Hemidesmosome formation is initiated by the beta4 integrin subunit, requires complex formation of beta4 and HD1/plectin, and involves a direct interaction between beta4 and the bullous pemphigoid antigen 180 | journal = The Journal of Cell Biology | volume = 142 | issue = 1 | pages = 271–84 | date = Jul 1998 | pmid = 9660880 | pmc = 2133016 | doi = 10.1083/jcb.142.1.271 }}</ref> [[EIF6]]<ref name=pmid9374518>{{cite journal | vauthors = Biffo S, Sanvito F, Costa S, Preve L, Pignatelli R, Spinardi L, Marchisio PC | title = Isolation of a novel beta4 integrin-binding protein (p27(BBP)) highly expressed in epithelial cells | journal = The Journal of Biological Chemistry | volume = 272 | issue = 48 | pages = 30314–21 | date = Nov 1997 | pmid = 9374518 | doi = 10.1074/jbc.272.48.30314 }}</ref> and [[Erbin (protein)|Erbin]].<ref name=pmid11375975>{{cite journal | vauthors = Favre B, Fontao L, Koster J, Shafaatian R, Jaunin F, Saurat JH, Sonnenberg A, Borradori L | title = The hemidesmosomal protein bullous pemphigoid antigen 1 and the integrin beta 4 subunit bind to ERBIN. Molecular cloning of multiple alternative splice variants of ERBIN and analysis of their tissue expression | journal = The Journal of Biological Chemistry | volume = 276 | issue = 35 | pages = 32427–36 | date = Aug 2001 | pmid = 11375975 | doi = 10.1074/jbc.M011005200 }}</ref>
 
== See also ==
* [[Cluster of differentiation]]
* [[Cluster of differentiation]]
* [[List of target antigens in pemphigoid]]


==References==
== References ==
{{reflist|2}}
{{reflist}}
{{clear}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin|33em}}
{{PBB_Further_reading
* {{cite journal | vauthors = Lipscomb EA, Mercurio AM | title = Mobilization and activation of a signaling competent alpha6beta4integrin underlies its contribution to carcinoma progression | journal = Cancer Metastasis Reviews | volume = 24 | issue = 3 | pages = 413–23 | date = Sep 2005 | pmid = 16258729 | doi = 10.1007/s10555-005-5133-4 }}
| citations =
* {{cite journal | vauthors = Sonnenberg A, Linders CJ, Modderman PW, Damsky CH, Aumailley M, Timpl R | title = Integrin recognition of different cell-binding fragments of laminin (P1, E3, E8) and evidence that alpha 6 beta 1 but not alpha 6 beta 4 functions as a major receptor for fragment E8 | journal = The Journal of Cell Biology | volume = 110 | issue = 6 | pages = 2145–55 | date = Jun 1990 | pmid = 1693624 | pmc = 2116116 | doi = 10.1083/jcb.110.6.2145 }}
*{{cite journal | author=Lipscomb EA, Mercurio AM |title=Mobilization and activation of a signaling competent alpha6beta4integrin underlies its contribution to carcinoma progression. |journal=Cancer Metastasis Rev. |volume=24 |issue= 3 |pages= 413-23 |year= 2006 |pmid= 16258729 |doi= 10.1007/s10555-005-5133-4 }}
* {{cite journal | vauthors = Tamura RN, Rozzo C, Starr L, Chambers J, Reichardt LF, Cooper HM, Quaranta V | title = Epithelial integrin alpha 6 beta 4: complete primary structure of alpha 6 and variant forms of beta 4 | journal = The Journal of Cell Biology | volume = 111 | issue = 4 | pages = 1593–604 | date = Oct 1990 | pmid = 1976638 | pmc = 2116232 | doi = 10.1083/jcb.111.4.1593 }}
*{{cite journal | author=Sonnenberg A, Linders CJ, Modderman PW, ''et al.'' |title=Integrin recognition of different cell-binding fragments of laminin (P1, E3, E8) and evidence that alpha 6 beta 1 but not alpha 6 beta 4 functions as a major receptor for fragment E8. |journal=J. Cell Biol. |volume=110 |issue= 6 |pages= 2145-55 |year= 1990 |pmid= 1693624 |doi= }}
* {{cite journal | vauthors = Hogervorst F, Kuikman I, van Kessel AG, Sonnenberg A | title = Molecular cloning of the human alpha 6 integrin subunit. Alternative splicing of alpha 6 mRNA and chromosomal localization of the alpha 6 and beta 4 genes | journal = European Journal of Biochemistry / FEBS | volume = 199 | issue = 2 | pages = 425–33 | date = Jul 1991 | pmid = 2070796 | doi = 10.1111/j.1432-1033.1991.tb16140.x }}
*{{cite journal | author=Tamura RN, Rozzo C, Starr L, ''et al.'' |title=Epithelial integrin alpha 6 beta 4: complete primary structure of alpha 6 and variant forms of beta 4. |journal=J. Cell Biol. |volume=111 |issue= 4 |pages= 1593-604 |year= 1990 |pmid= 1976638 |doi= }}
* {{cite journal | vauthors = Vogel BE, Tarone G, Giancotti FG, Gailit J, Ruoslahti E | title = A novel fibronectin receptor with an unexpected subunit composition (alpha v beta 1) | journal = The Journal of Biological Chemistry | volume = 265 | issue = 11 | pages = 5934–7 | date = Apr 1990 | pmid = 2138612 | doi =  }}
*{{cite journal | author=Hogervorst F, Kuikman I, van Kessel AG, Sonnenberg A |title=Molecular cloning of the human alpha 6 integrin subunit. Alternative splicing of alpha 6 mRNA and chromosomal localization of the alpha 6 and beta 4 genes. |journal=Eur. J. Biochem. |volume=199 |issue= 2 |pages= 425-33 |year= 1991 |pmid= 2070796 |doi= }}
* {{cite journal | vauthors = Suzuki S, Naitoh Y | title = Amino acid sequence of a novel integrin beta 4 subunit and primary expression of the mRNA in epithelial cells | journal = The EMBO Journal | volume = 9 | issue = 3 | pages = 757–63 | date = Mar 1990 | pmid = 2311577 | pmc = 551732 | doi =  }}
*{{cite journal | author=Vogel BE, Tarone G, Giancotti FG, ''et al.'' |title=A novel fibronectin receptor with an unexpected subunit composition (alpha v beta 1). |journal=J. Biol. Chem. |volume=265 |issue= 11 |pages= 5934-7 |year= 1990 |pmid= 2138612 |doi=  }}
* {{cite journal | vauthors = Hogervorst F, Kuikman I, von dem Borne AE, Sonnenberg A | title = Cloning and sequence analysis of beta-4 cDNA: an integrin subunit that contains a unique 118 kd cytoplasmic domain | journal = The EMBO Journal | volume = 9 | issue = 3 | pages = 765–70 | date = Mar 1990 | pmid = 2311578 | pmc = 551734 | doi =  }}
*{{cite journal | author=Suzuki S, Naitoh Y |title=Amino acid sequence of a novel integrin beta 4 subunit and primary expression of the mRNA in epithelial cells. |journal=EMBO J. |volume=9 |issue= 3 |pages= 757-63 |year= 1990 |pmid= 2311577 |doi=  }}
* {{cite journal | vauthors = Kajiji S, Tamura RN, Quaranta V | title = A novel integrin (alpha E beta 4) from human epithelial cells suggests a fourth family of integrin adhesion receptors | journal = The EMBO Journal | volume = 8 | issue = 3 | pages = 673–80 | date = Mar 1989 | pmid = 2542022 | pmc = 400860 | doi =  }}
*{{cite journal | author=Hogervorst F, Kuikman I, von dem Borne AE, Sonnenberg A |title=Cloning and sequence analysis of beta-4 cDNA: an integrin subunit that contains a unique 118 kd cytoplasmic domain. |journal=EMBO J. |volume=9 |issue= 3 |pages= 765-70 |year= 1990 |pmid= 2311578 |doi=  }}
* {{cite journal | vauthors = Hemler ME, Crouse C, Sonnenberg A | title = Association of the VLA alpha 6 subunit with a novel protein. A possible alternative to the common VLA beta 1 subunit on certain cell lines | journal = The Journal of Biological Chemistry | volume = 264 | issue = 11 | pages = 6529–35 | date = Apr 1989 | pmid = 2649503 | doi =  }}
*{{cite journal | author=Kajiji S, Tamura RN, Quaranta V |title=A novel integrin (alpha E beta 4) from human epithelial cells suggests a fourth family of integrin adhesion receptors. |journal=EMBO J. |volume=8 |issue= 3 |pages= 673-80 |year= 1989 |pmid= 2542022 |doi=  }}
* {{cite journal | vauthors = Vidal F, Aberdam D, Miquel C, Christiano AM, Pulkkinen L, Uitto J, Ortonne JP, Meneguzzi G | title = Integrin beta 4 mutations associated with junctional epidermolysis bullosa with pyloric atresia | journal = Nature Genetics | volume = 10 | issue = 2 | pages = 229–34 | date = Jun 1995 | pmid = 7545057 | doi = 10.1038/ng0695-229 }}
*{{cite journal | author=Hemler ME, Crouse C, Sonnenberg A |title=Association of the VLA alpha 6 subunit with a novel protein. A possible alternative to the common VLA beta 1 subunit on certain cell lines. |journal=J. Biol. Chem. |volume=264 |issue= 11 |pages= 6529-35 |year= 1989 |pmid= 2649503 |doi=  }}
* {{cite journal | vauthors = Mainiero F, Pepe A, Wary KK, Spinardi L, Mohammadi M, Schlessinger J, Giancotti FG | title = Signal transduction by the alpha 6 beta 4 integrin: distinct beta 4 subunit sites mediate recruitment of Shc/Grb2 and association with the cytoskeleton of hemidesmosomes | journal = The EMBO Journal | volume = 14 | issue = 18 | pages = 4470–81 | date = Sep 1995 | pmid = 7556090 | pmc = 394539 | doi =  }}
*{{cite journal | author=Vidal F, Aberdam D, Miquel C, ''et al.'' |title=Integrin beta 4 mutations associated with junctional epidermolysis bullosa with pyloric atresia. |journal=Nat. Genet. |volume=10 |issue= 2 |pages= 229-34 |year= 1995 |pmid= 7545057 |doi= 10.1038/ng0695-229 }}
* {{cite journal | vauthors = Clarke AS, Lotz MM, Mercurio AM | title = A novel structural variant of the human beta 4 integrin cDNA | journal = Cell Adhesion and Communication | volume = 2 | issue = 1 | pages = 1–6 | date = Apr 1994 | pmid = 7982032 | doi = 10.3109/15419069409014197 }}
*{{cite journal | author=Mainiero F, Pepe A, Wary KK, ''et al.'' |title=Signal transduction by the alpha 6 beta 4 integrin: distinct beta 4 subunit sites mediate recruitment of Shc/Grb2 and association with the cytoskeleton of hemidesmosomes. |journal=EMBO J. |volume=14 |issue= 18 |pages= 4470-81 |year= 1995 |pmid= 7556090 |doi=  }}
* {{cite journal | vauthors = Weeks BS, Desai K, Loewenstein PM, Klotman ME, Klotman PE, Green M, Kleinman HK | title = Identification of a novel cell attachment domain in the HIV-1 Tat protein and its 90-kDa cell surface binding protein | journal = The Journal of Biological Chemistry | volume = 268 | issue = 7 | pages = 5279–84 | date = Mar 1993 | pmid = 8444901 | doi =  }}
*{{cite journal | author=Clarke AS, Lotz MM, Mercurio AM |title=A novel structural variant of the human beta 4 integrin cDNA. |journal=Cell Adhes. Commun. |volume=2 |issue= 1 |pages= 1-6 |year= 1995 |pmid= 7982032 |doi= }}
* {{cite journal | vauthors = Iacovacci S, Gagnoux-Palacios L, Zambruno G, Meneguzzi G, D'Alessio M | title = Genomic organization of the human integrin beta4 gene | journal = Mammalian Genome | volume = 8 | issue = 6 | pages = 448–50 | date = Jun 1997 | pmid = 9166594 | doi = 10.1007/s003359900467 }}
*{{cite journal | author=Weeks BS, Desai K, Loewenstein PM, ''et al.'' |title=Identification of a novel cell attachment domain in the HIV-1 Tat protein and its 90-kDa cell surface binding protein. |journal=J. Biol. Chem. |volume=268 |issue= 7 |pages= 5279-84 |year= 1993 |pmid= 8444901 |doi=  }}
* {{cite journal | vauthors = Mainiero F, Murgia C, Wary KK, Curatola AM, Pepe A, Blumemberg M, Westwick JK, Der CJ, Giancotti FG | title = The coupling of alpha6beta4 integrin to Ras-MAP kinase pathways mediated by Shc controls keratinocyte proliferation | journal = The EMBO Journal | volume = 16 | issue = 9 | pages = 2365–75 | date = May 1997 | pmid = 9171350 | pmc = 1169837 | doi = 10.1093/emboj/16.9.2365 }}
*{{cite journal | author=Iacovacci S, Gagnoux-Palacios L, Zambruno G, ''et al.'' |title=Genomic organization of the human integrin beta4 gene. |journal=Mamm. Genome |volume=8 |issue= 6 |pages= 448-50 |year= 1997 |pmid= 9166594 |doi= }}
* {{cite journal | vauthors = Pulkkinen L, Kurtz K, Xu Y, Bruckner-Tuderman L, Uitto J | title = Genomic organization of the integrin beta 4 gene (ITGB4): a homozygous splice-site mutation in a patient with junctional epidermolysis bullosa associated with pyloric atresia | journal = Laboratory Investigation | volume = 76 | issue = 6 | pages = 823–33 | date = Jun 1997 | pmid = 9194858 | doi =  }}
*{{cite journal | author=Mainiero F, Murgia C, Wary KK, ''et al.'' |title=The coupling of alpha6beta4 integrin to Ras-MAP kinase pathways mediated by Shc controls keratinocyte proliferation. |journal=EMBO J. |volume=16 |issue= 9 |pages= 2365-75 |year= 1997 |pmid= 9171350 |doi= 10.1093/emboj/16.9.2365 }}
* {{cite journal | vauthors = van Leusden MR, Kuikman I, Sonnenberg A | title = The unique cytoplasmic domain of the human integrin variant beta4E is produced by partial retention of intronic sequences | journal = Biochemical and Biophysical Research Communications | volume = 235 | issue = 3 | pages = 826–30 | date = Jun 1997 | pmid = 9207246 | doi = 10.1006/bbrc.1997.6892 }}
*{{cite journal | author=Pulkkinen L, Kurtz K, Xu Y, ''et al.'' |title=Genomic organization of the integrin beta 4 gene (ITGB4): a homozygous splice-site mutation in a patient with junctional epidermolysis bullosa associated with pyloric atresia. |journal=Lab. Invest. |volume=76 |issue= 6 |pages= 823-33 |year= 1997 |pmid= 9194858 |doi=  }}
* {{cite journal | vauthors = von Bredow DC, Nagle RB, Bowden GT, Cress AE | title = Cleavage of beta 4 integrin by matrilysin | journal = Experimental Cell Research | volume = 236 | issue = 1 | pages = 341–5 | date = Oct 1997 | pmid = 9344615 | doi = 10.1006/excr.1997.3711 }}
*{{cite journal | author=van Leusden MR, Kuikman I, Sonnenberg A |title=The unique cytoplasmic domain of the human integrin variant beta4E is produced by partial retention of intronic sequences. |journal=Biochem. Biophys. Res. Commun. |volume=235 |issue= 3 |pages= 826-30 |year= 1997 |pmid= 9207246 |doi= 10.1006/bbrc.1997.6892 }}
* {{cite journal | vauthors = Biffo S, Sanvito F, Costa S, Preve L, Pignatelli R, Spinardi L, Marchisio PC | title = Isolation of a novel beta4 integrin-binding protein (p27(BBP)) highly expressed in epithelial cells | journal = The Journal of Biological Chemistry | volume = 272 | issue = 48 | pages = 30314–21 | date = Nov 1997 | pmid = 9374518 | doi = 10.1074/jbc.272.48.30314 }}
*{{cite journal | author=von Bredow DC, Nagle RB, Bowden GT, Cress AE |title=Cleavage of beta 4 integrin by matrilysin. |journal=Exp. Cell Res. |volume=236 |issue= 1 |pages= 341-5 |year= 1997 |pmid= 9344615 |doi= 10.1006/excr.1997.3711 }}
* {{cite journal | vauthors = Pulkkinen L, Kim DU, Uitto J | title = Epidermolysis bullosa with pyloric atresia: novel mutations in the beta4 integrin gene (ITGB4) | journal = The American Journal of Pathology | volume = 152 | issue = 1 | pages = 157–66 | date = Jan 1998 | pmid = 9422533 | pmc = 1858138 | doi =  }}
*{{cite journal | author=Biffo S, Sanvito F, Costa S, ''et al.'' |title=Isolation of a novel beta4 integrin-binding protein (p27(BBP)) highly expressed in epithelial cells. |journal=J. Biol. Chem. |volume=272 |issue= 48 |pages= 30314-21 |year= 1997 |pmid= 9374518 |doi= }}
* {{cite journal | vauthors = Hughes AE, Bradley DT, Campbell M, Lechner J, Dash DP, Simpson DA, Willoughby CE | title = Mutation altering the miR-184 seed region causes familial keratoconus with cataract | journal = American Journal of Human Genetics | volume = 89 | issue = 5 | pages = 628–33 | date = Nov 2011 | pmid = 21996275 | pmc = 3213395 | doi = 10.1016/j.ajhg.2011.09.014 | url = http://www.cell.com/AJHG/abstract/S0002-9297(11)00404-6 }}
*{{cite journal | author=Pulkkinen L, Kim DU, Uitto J |title=Epidermolysis bullosa with pyloric atresia: novel mutations in the beta4 integrin gene (ITGB4). |journal=Am. J. Pathol. |volume=152 |issue= 1 |pages= 157-66 |year= 1998 |pmid= 9422533 |doi=  }}
}}
{{refend}}
{{refend}}


==External links==
== External links ==
* [https://www.ncbi.nlm.nih.gov/books/NBK1157/  GeneReviews/NCBI/NIH/UW entry on Epidermolysis Bullosa with Pyloric Atresia]
* {{MeshName|ITGB4+protein,+human}}
* {{MeshName|ITGB4+protein,+human}}
*[http://cmkb.cellmigration.org/report.cgi?report=orth_overview&orth_acc=co00001468 ITGB4] Info with links in the [http://www.cellmigration.org/index.shtml Cell Migration Gateway]


{{membrane-protein-stub}}
{{NLM content}}
{{NLM content}}
{{PDB Gallery|geneid=3691}}
{{Clusters of differentiation}}
{{Clusters of differentiation}}
{{Integrins}}
[[Category:Clusters of differentiation]]
[[Category:Clusters of differentiation]]
{{WikiDoc Sources}}
[[Category:Integrins]]

Latest revision as of 00:11, 1 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Integrin, beta 4 (ITGB4) also known as CD104 (Cluster of Differentiation 104), is a human gene.[1]

Function

Integrins are heterodimers composed of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[1]

Interactions

ITGB4 has been shown to interact with Collagen, type XVII, alpha 1,[2][3] EIF6[4] and Erbin.[5]

See also

References

  1. ↑ 1.0 1.1 "Entrez Gene: ITGB4 integrin, beta 4".
  2. ↑ Aho S, Uitto J (Feb 1998). "Direct interaction between the intracellular domains of bullous pemphigoid antigen 2 (BP180) and beta 4 integrin, hemidesmosomal components of basal keratinocytes". Biochemical and Biophysical Research Communications. 243 (3): 694–9. doi:10.1006/bbrc.1998.8162. PMID 9500991.
  3. ↑ Schaapveld RQ, Borradori L, Geerts D, van Leusden MR, Kuikman I, Nievers MG, Niessen CM, Steenbergen RD, Snijders PJ, Sonnenberg A (Jul 1998). "Hemidesmosome formation is initiated by the beta4 integrin subunit, requires complex formation of beta4 and HD1/plectin, and involves a direct interaction between beta4 and the bullous pemphigoid antigen 180". The Journal of Cell Biology. 142 (1): 271–84. doi:10.1083/jcb.142.1.271. PMC 2133016. PMID 9660880.
  4. ↑ Biffo S, Sanvito F, Costa S, Preve L, Pignatelli R, Spinardi L, Marchisio PC (Nov 1997). "Isolation of a novel beta4 integrin-binding protein (p27(BBP)) highly expressed in epithelial cells". The Journal of Biological Chemistry. 272 (48): 30314–21. doi:10.1074/jbc.272.48.30314. PMID 9374518.
  5. ↑ Favre B, Fontao L, Koster J, Shafaatian R, Jaunin F, Saurat JH, Sonnenberg A, Borradori L (Aug 2001). "The hemidesmosomal protein bullous pemphigoid antigen 1 and the integrin beta 4 subunit bind to ERBIN. Molecular cloning of multiple alternative splice variants of ERBIN and analysis of their tissue expression". The Journal of Biological Chemistry. 276 (35): 32427–36. doi:10.1074/jbc.M011005200. PMID 11375975.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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