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WikiDoc Resources for Hypophosphatasia


Most recent articles on Hypophosphatasia

Most cited articles on Hypophosphatasia

Review articles on Hypophosphatasia

Articles on Hypophosphatasia in N Eng J Med, Lancet, BMJ


Powerpoint slides on Hypophosphatasia

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Evidence Based Medicine

Cochrane Collaboration on Hypophosphatasia

Bandolier on Hypophosphatasia

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Clinical Trials

Ongoing Trials on Hypophosphatasia at Clinical Trials.gov

Trial results on Hypophosphatasia

Clinical Trials on Hypophosphatasia at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Hypophosphatasia

NICE Guidance on Hypophosphatasia


FDA on Hypophosphatasia

CDC on Hypophosphatasia


Books on Hypophosphatasia


Hypophosphatasia in the news

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Blogs on Hypophosphatasia


Definitions of Hypophosphatasia

Patient Resources / Community

Patient resources on Hypophosphatasia

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Directions to Hospitals Treating Hypophosphatasia

Risk calculators and risk factors for Hypophosphatasia

Healthcare Provider Resources

Symptoms of Hypophosphatasia

Causes & Risk Factors for Hypophosphatasia

Diagnostic studies for Hypophosphatasia

Treatment of Hypophosphatasia

Continuing Medical Education (CME)

CME Programs on Hypophosphatasia


Hypophosphatasia en Espanol

Hypophosphatasia en Francais


Hypophosphatasia in the Marketplace

Patents on Hypophosphatasia

Experimental / Informatics

List of terms related to Hypophosphatasia

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]


Hypophosphatasia is a rare inherited metabolic disease of decreased tissue nonspecific alkaline phosphatase (TNSALP) and defective bone mineralization. Both autosomal recessive and autosomal dominant variants of the disease exist. The disease comes in one of five forms, perinatal, infantile, childhood, adult, and odontohypophosphatasia. Perinatal hypophosphatasia is invariably lethal while infantile hypophosphatasia has a roughly 50% mortality rate with symptoms appearing within the first 6th months after birth. The other forms are generally non-lethal. Common symptoms include bone malformations and higher chance of bone fracture. Both the adult form and odontohypophosphatasial form are marked by premature teeth loss.

There is no known cure for hypophosphatasia. However, there have been some claims that choline may have positive health benefits for those with the disease that take it as a dietary supplement.


Rathbun J. (1948). "Hypophosphatasia, a new developmental anomaly". Am J Dis Child. 75: 822–827.


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