Hypertrophic cardiomyopathy pathologic abnormalities: Difference between revisions

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==Microscopic Pathological Findings==


Histopathologically, small vessels have hypertrophy of the tunica media.  Combined with increased wall tension, decreased vasodilator reserve and inadequate capillary density, there is a mismatch between blood supply and demand.  Over time, it is thought that there is repeated ischemia followed by fibrosis and eventually, dilation and systolic dysfunction (“burned out hypertrophy”).
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Image:3380.jpg|Micro med mag H&E mid-mural myocardium with hypertrophy and interstitial fibrosis atrophy is present marked increase in interstitial fibroblastic cells
Image:3381.jpg|Micro high mag H&E myofiber hypertrophy and interstitial fibrosis with marked increase in interstitial fibroblastic cells
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Image:3480.jpg|Micro med mag H&E myofiber hypertrophy some atrophy interstitial fibrosis with many fibroblastic cells
Image:3481.jpg|Micro high mag H&E hypertrophied fibers with some evidence of atrophy and marked interstitial fibrosis with many fibroblastic type cells
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Image:3482.jpg|Micro low mag H&E shows myofiber hypertrophy and interstitial fibrosis
Image:439.jpg|Cardiomyopathy: Micro H&E low mag interventricular septum at junction of normal myofiber orientation with asymmetrical hypertrophy (an excellent example)
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Image:440.jpg|Cardiomyopathy: Micro H&E low mag marked myofiber disarray asymmetrical hypertrophy
Image:441.jpg|Cardiomyopathy: Micro trichrome high mag marked myofiber disarray
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Image:442.jpg|Cardiomyopathy: Micro H&E med mag excellent example myofiber disarray
Image:438.jpg|Cardiomyopathy: Micro H&E high mag excellent example myofiber disarray
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==References==
==References==

Latest revision as of 18:26, 14 August 2011

Hypertrophic Cardiomyopathy Microchapters

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Overview

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Differentiating Hypertrophic Cardiomyopathy from other Diseases

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Risk calculators and risk factors for Hypertrophic cardiomyopathy pathologic abnormalities

Overview

Gross Pathological Findings

  • Cardiomyopathy: Intermediate between hypertrophic and dilated

    Cardiomyopathy: Intermediate between hypertrophic and dilated

  • Hypertrophic cardiomyopathy, concentric

    Hypertrophic cardiomyopathy, concentric


  • Hypertrophic Obstructive Cardiomyopathy: Gross natural color opened left ventricular outflow tract with subaortic shelf and marked endocardial thickening matching the contour of the anterior mitral leaflet

    Hypertrophic Obstructive Cardiomyopathy: Gross natural color opened left ventricular outflow tract with subaortic shelf and marked endocardial thickening matching the contour of the anterior mitral leaflet

  • Cardiomyopathy: Gross apical slice of left and right ventricles concentric hypertrophy with cavitary obliteration sudden unexpected death obstructive cardiomyopathy

    Cardiomyopathy: Gross apical slice of left and right ventricles concentric hypertrophy with cavitary obliteration sudden unexpected death obstructive cardiomyopathy


  • Cardiomyopathy Asymmetrical Septal Hypertrophy

    Cardiomyopathy Asymmetrical Septal Hypertrophy

  • Cardiomyopathy: Gross excellent view of mitral valve atrial surface showing thickening which is fibrous in body of valve and myxoid at area of free margin changes presumed secondary to insufficiency due to anterior motion

    Cardiomyopathy: Gross excellent view of mitral valve atrial surface showing thickening which is fibrous in body of valve and myxoid at area of free margin changes presumed secondary to insufficiency due to anterior motion


  • Cardiomyopathy: Gross close up view of a ventricle slice

    Cardiomyopathy: Gross close up view of a ventricle slice

  • Cardiomyopathy: Gross ventricular slices hypertrophy and extensive myocardial fibrosis a unique case of global fiber disarray with atrophy and fibrosis

    Cardiomyopathy: Gross ventricular slices hypertrophy and extensive myocardial fibrosis a unique case of global fiber disarray with atrophy and fibrosis


References

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