Hypertriglyceridemia niacin
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Priyamvada Singh, M.B.B.S. [2]
Overview
Treatment of hypertriglyceridemia is by restriction of carbohydrates and fat in the diet, as well as with niacin, fibrates and statins (three classes of drugs). Increased fish oil intake may substantially lower an individual's triglycerides.[1][2][3].
Niacin/Nicotinic acid
Mechanism of benefit
- Reduces the level of low density lipoprotein (LDL) (17-26%)[4]
- Increases the level of high density lipoprotein (HDL)
Dosage
1.5 - 2 gm once daily
Advantages
- Statin alone or combination therapy of niacin with statin are usually the first options used in patients with increased risk of premature coronary artery disease.
- Decreases the progression of atherosclerosis in hypertriglyceridemia patients.
Side-effects
- Flushing
- Pruritus
- Nausea
- Hepatitis (higher doses)
Contraindication
- Hypersensitivity
- Hepatic disease
Supportive trial data
References
- ↑ "Lipids Online Slides: hypertriglyceridemia, ICAM-1, fish oil, E-selectin".
- ↑ Terres W, Beil U, Reimann B, Tiede S, Bleifeld W (1991). "[Low-dose fish oil in primary hypertriglyceridemia. A randomized placebo-controlled study]". Zeitschrift für Kardiologie (in German). 80 (1): 20–4. PMID 2035283.
- ↑ "Fish oils in hypertriglyceridemia - Fish Oils Revisited Nutrition Research Newsletter - Find Articles".
- ↑ Brunzell JD (2007). "Clinical practice. Hypertriglyceridemia". N Engl J Med. 357 (10): 1009–17. doi:10.1056/NEJMcp070061. PMID 17804845.