Hypertriglyceridemia niacin: Difference between revisions
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Treatment of hypertriglyceridemia is by restriction of carbohydrates and fat in the [[diet (nutrition)|diet]], as well as with [[niacin]], [[fibrate]]s and [[statin]]s (three classes of drugs). Increased [[fish oil]] intake may substantially lower an individual's triglycerides.<ref>{{cite web |url=http://www.lipidsonline.org/slides/slide01.cfm?q=hypertriglyceridemia&dpg=13 |title=Lipids Online Slides: hypertriglyceridemia, ICAM-1, fish oil, E-selectin | format= |work=}}</ref><ref name="pmid2035283">{{cite journal |author=Terres W, Beil U, Reimann B, Tiede S, Bleifeld W |title=[Low-dose fish oil in primary hypertriglyceridemia. A randomized placebo-controlled study] |language=German |journal=Zeitschrift für Kardiologie |volume=80 |issue=1 |pages=20-4 |year=1991 |pmid=2035283 |doi=}}</ref><ref>{{cite web |url=http://www.findarticles.com/p/articles/mi_m0887/is_n4_v9/ai_8960077 |title=Fish oils in hypertriglyceridemia - Fish Oils Revisited Nutrition Research Newsletter - Find Articles |format= |work=}}</ref>. | Treatment of hypertriglyceridemia is by restriction of carbohydrates and fat in the [[diet (nutrition)|diet]], as well as with [[niacin]], [[fibrate]]s and [[statin]]s (three classes of drugs). Increased [[fish oil]] intake may substantially lower an individual's triglycerides.<ref>{{cite web |url=http://www.lipidsonline.org/slides/slide01.cfm?q=hypertriglyceridemia&dpg=13 |title=Lipids Online Slides: hypertriglyceridemia, ICAM-1, fish oil, E-selectin | format= |work=}}</ref><ref name="pmid2035283">{{cite journal |author=Terres W, Beil U, Reimann B, Tiede S, Bleifeld W |title=[Low-dose fish oil in primary hypertriglyceridemia. A randomized placebo-controlled study] |language=German |journal=Zeitschrift für Kardiologie |volume=80 |issue=1 |pages=20-4 |year=1991 |pmid=2035283 |doi=}}</ref><ref>{{cite web |url=http://www.findarticles.com/p/articles/mi_m0887/is_n4_v9/ai_8960077 |title=Fish oils in hypertriglyceridemia - Fish Oils Revisited Nutrition Research Newsletter - Find Articles |format= |work=}}</ref>. | ||
==Mechanism of benefit== | ==Niacin/Nicotinic acid== | ||
===Mechanism of benefit=== | |||
* Reduce levels of low density lipoprotein (LDL) | * Reduce levels of low density lipoprotein (LDL) | ||
* Increases the level of HDL2 particles | * Increases the level of HDL2 particles | ||
==Advantages== | ===Advantages=== | ||
* Combination therapy of niacin with statin or statin alone are usually the first options used in patients with increased risk of premature coronary artery disease. | * Combination therapy of niacin with statin or statin alone are usually the first options used in patients with increased risk of premature coronary artery disease. | ||
* Decreases the progression of atherosclerosis in hypertriglyceridemia patients. | * Decreases the progression of atherosclerosis in hypertriglyceridemia patients. | ||
==Side-effects== | ===Side-effects=== | ||
* Flushing | * Flushing | ||
* Pruritus | * Pruritus | ||
* Nausea | * Nausea | ||
* Hepatitis (higher doses) | * Hepatitis (higher doses) | ||
==Contraindication== | ===Contraindication=== | ||
* Hypersensitivity | * Hypersensitivity | ||
* Hepatic disease | * Hepatic disease | ||
==Supportive trial data== | ===Supportive trial data=== | ||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
Revision as of 02:04, 4 October 2011
For full Omega-3 fatty acid drug info click here
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Priyamvada Singh, M.B.B.S. [2]
Overview
Treatment of hypertriglyceridemia is by restriction of carbohydrates and fat in the diet, as well as with niacin, fibrates and statins (three classes of drugs). Increased fish oil intake may substantially lower an individual's triglycerides.[1][2][3].
Niacin/Nicotinic acid
Mechanism of benefit
- Reduce levels of low density lipoprotein (LDL)
- Increases the level of HDL2 particles
Advantages
- Combination therapy of niacin with statin or statin alone are usually the first options used in patients with increased risk of premature coronary artery disease.
- Decreases the progression of atherosclerosis in hypertriglyceridemia patients.
Side-effects
- Flushing
- Pruritus
- Nausea
- Hepatitis (higher doses)
Contraindication
- Hypersensitivity
- Hepatic disease
Supportive trial data
References
- ↑ "Lipids Online Slides: hypertriglyceridemia, ICAM-1, fish oil, E-selectin".
- ↑ Terres W, Beil U, Reimann B, Tiede S, Bleifeld W (1991). "[Low-dose fish oil in primary hypertriglyceridemia. A randomized placebo-controlled study]". Zeitschrift für Kardiologie (in German). 80 (1): 20–4. PMID 2035283.
- ↑ "Fish oils in hypertriglyceridemia - Fish Oils Revisited Nutrition Research Newsletter - Find Articles".