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{{CMG}} {{AE}} {{AN}}
{{CMG}} {{AE}} {{AN}}{{NN}}
==Classification==
==Classification==
Hypertensive nephropathy is divided into two distinct entities:
Hypertensive nephropathy is classified according to disease severity and histological finding into two subtypes<ref name="OnoOno1997">{{cite journal|last1=Ono|first1=Hidehiko|last2=Ono|first2=Yuko|title=NEPHROSCLEROSIS AND HYPERTENSION|journal=Medical Clinics of North America|volume=81|issue=6|year=1997|pages=1273–1288|issn=00257125|doi=10.1016/S0025-7125(05)70582-4}}</ref>:


* Benign arteriolar nephrosclerosis
* '''Benign nephrosclerosis'''
** Seen in patients who are hypertensive for a long period of time (> 150/90 mm Hg) but has not progressed to malignant stage.
**It often occurs in the benign phase of essential [[hypertension]].
* Malignant (accelerated) arteriolar nephrosclerosis
** It is characterized by [[Hyaline]] accumulation in the renal arterioles leading to afferent arteriolar narrowing.
** Characterized by sudden elevation of [[blood pressure]] ([[diastolic pressure]] > 130 mm Hg) along with [[papilledema]], central nervous system manifestations like [[confusion]], cardiac decompensation and acute progressive decline in renal function.
[[File:Renal arterial hyalinosis - pas - very high mag.jpg|300px|center]]


* '''Malignant nephrosclerosis'''
** It occurs in the malignant phase of essential [[hypertension]], which is defined by a sudden elevation of [[blood pressure]] along with multi-organ damage such as [[papilledema]], central nervous system involvement, cardiac decompensation, and progressive renal failure.
** It is characterized by [[fibrinoid]] necrosis in the afferent arterioles.
==References==
==References==
{{reflist|2}}
{{reflist|2}}

Latest revision as of 23:01, 7 June 2020

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Aarti Narayan, M.B.B.S [2]Nasrin Nikravangolsefid, MD-MPH [3]

Classification

Hypertensive nephropathy is classified according to disease severity and histological finding into two subtypes[1]:

  • Benign nephrosclerosis
    • It often occurs in the benign phase of essential hypertension.
    • It is characterized by Hyaline accumulation in the renal arterioles leading to afferent arteriolar narrowing.



  • Malignant nephrosclerosis
    • It occurs in the malignant phase of essential hypertension, which is defined by a sudden elevation of blood pressure along with multi-organ damage such as papilledema, central nervous system involvement, cardiac decompensation, and progressive renal failure.
    • It is characterized by fibrinoid necrosis in the afferent arterioles.

References

  1. Ono, Hidehiko; Ono, Yuko (1997). "NEPHROSCLEROSIS AND HYPERTENSION". Medical Clinics of North America. 81 (6): 1273–1288. doi:10.1016/S0025-7125(05)70582-4. ISSN 0025-7125.

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