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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Associate Editor-In-Chief: Cafer Zorkun, M.D., Ph.D. [2]


Bended thumb as example of hypermobility
ICD-10 M35.7
ICD-9 728.5
OMIM 147900
DiseasesDB 31101

WikiDoc Resources for Hypermobility


Most recent articles on Hypermobility

Most cited articles on Hypermobility

Review articles on Hypermobility

Articles on Hypermobility in N Eng J Med, Lancet, BMJ


Powerpoint slides on Hypermobility

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Photos of Hypermobility

Podcasts & MP3s on Hypermobility

Videos on Hypermobility

Evidence Based Medicine

Cochrane Collaboration on Hypermobility

Bandolier on Hypermobility

TRIP on Hypermobility

Clinical Trials

Ongoing Trials on Hypermobility at Clinical Trials.gov

Trial results on Hypermobility

Clinical Trials on Hypermobility at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Hypermobility

NICE Guidance on Hypermobility


FDA on Hypermobility

CDC on Hypermobility


Books on Hypermobility


Hypermobility in the news

Be alerted to news on Hypermobility

News trends on Hypermobility


Blogs on Hypermobility


Definitions of Hypermobility

Patient Resources / Community

Patient resources on Hypermobility

Discussion groups on Hypermobility

Patient Handouts on Hypermobility

Directions to Hospitals Treating Hypermobility

Risk calculators and risk factors for Hypermobility

Healthcare Provider Resources

Symptoms of Hypermobility

Causes & Risk Factors for Hypermobility

Diagnostic studies for Hypermobility

Treatment of Hypermobility

Continuing Medical Education (CME)

CME Programs on Hypermobility


Hypermobility en Espanol

Hypermobility en Francais


Hypermobility in the Marketplace

Patents on Hypermobility

Experimental / Informatics

List of terms related to Hypermobility

Hypermobility (also called double-jointedness, hypermobility syndrome or hyperlaxity) describes joints that stretch farther than is normal. For example, some hypermobile people can bend their thumbs backwards to their wrists, or bend their knee joints backwards. It can affect a single joint or multiple joints throughout the body.


Hypermobility generally results from one or more of the following:

The condition tends to run in families, suggesting that there may be a genetic basis for at least some forms of hypermobility. The term double jointed is often used to describe hypermobility, however the name is a misnomer and is not to be taken literally, as an individual with hypermobility in a joint does not actually have two separate joints where others would have just the one.

Some people have hypermobility with no other symptoms or medical conditions. However, people with hypermobility syndrome may experience many difficulties. For example, their joints may be easily injured, and they may develop problems from muscle overuse (as muscles must work harder to compensate for the excessive weakness in the ligaments that support the joints).

Hypermobility may also be symptomatic of a serious medical condition, such as Ehlers-Danlos Syndrome, Marfan syndrome, rheumatoid arthritis, osteogenesis imperfecta, lupus, polio, down syndrome, morquio syndrome, cleidocranial dysostosis or myotonia congenita.

In addition, hypermobility has been associated with chronic fatigue syndrome and fibromyalgia.

Hypermobility Syndrome

Hypermobility syndrome (known by a variety of other names, including Benign Joint Hypermobility Syndrome) is generally considered to comprise hypermobility together with other symptoms, such as myalgia and arthralgia, and extra-articular features such as skin hyperextensibility and varicose veins. It affects more females than males.

The current diagnostic criteria for hypermobility syndrome are the Brighton criteria, which incorporates the Beighton score[3]. Hypermobility syndrome is considered by many doctors expert in hypermobility (e.g. Professor Rodney Grahame) to be equivalent to the Hypermobile Type of Ehlers-Danlos Syndrome.

People with hypermobility syndrome may develop other conditions caused by their lax connective tissues. These conditions include

  1. Gastroesophageal Reflux Disease (GERD)
  2. Irritable Bowel Syndrome (IBS)
  3. Varicose Veins
  4. Flat feet, pronated feet, plantar fasciitis or sesamoiditis and unsupportive shoes
  5. Idiopathic scoliosis
  6. Joint instability causing frequent sprains, tendinitis, or bursitis when doing activities that would not affect the normal individual.
  7. Early-onset osteoarthritis
  8. There is evidence linking hypermobility syndrome to anxiety and depression. [4][5]
  9. Subluxations or dislocations, especially in the shoulder.
  10. Knee pain
  11. Back pain, prolapsed discs or spondylolisthesis
  12. Hernias
  13. Bruising easily
  14. Worsening of symptoms in cold weather
  15. Joints that make clicking noises
  16. Headaches
  17. Susceptibility to whiplash
  18. Temporomandibular Joint Syndrome also known as TMJ syndrome
  19. Increased nerve compression disorders (i.e. carpal tunnel syndrome)
  20. Mitral valve prolapse
  21. Uterine prolapse


Physical therapy

It is important that the individual with hypermobility remain extremely fit - even more so than the average individual - to prevent recurrent injuries. Regular exercise and physical therapy or hydrotherapy can reduce symptoms of hypermobility, because strong muscles help to stabilize joints. These treatments can also help by stretching tight, overused muscles and ensuring that the person can use their full, hypermobile range of motion. Low-impact exercise such as Pilates is usually recommended for hypermobile people as it is less likely to cause injury than high-impact exercise or contact sports.

Moist hot packs can relieve the pain of aching joints and muscles. For some patients, ice packs also help to relieve pain.


Medications frequently used to reduce pain and inflammation caused by hypermobility include analgesics, anti-inflammatory drugs, and tricyclic antidepressants. Some people with hypermobility may benefit from other medications such as steroid injections or gabapentin, a drug originally used for treating epilepsy.

Lifestyle modification

For many people with hypermobility, lifestyle changes decrease the severity of symptoms. For example:

  • If writing is painful, people may be able to reduce the pain by typing.
  • If typing is painful, they may try voice control software for their computer.
  • They should avoid over-stretching the joints - stretching to one's maximum capabilities may result in injuries. Just because they are able to stretch much further, doesn't mean that it is a good idea.
  • They should watch their posture to make sure they are standing or sitting up straight. Weakened ligaments & muscles contribute to poor posture which may result in numerous other medical conditions.

Other treatments

  • Bracing to support weak joints may be helpful, but caution must be used not to weaken the joints further.
  • Those who are overweight should lose weight. The extra weight puts additional stress on the already weakened ligaments, making them more susceptible to injury.

See also

Support Sites

External links

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