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| #*[[Hyperlipidemia statins in children and adolescents with hyperlipidemia | Statins]] | | #*[[Hyperlipidemia statins in children and adolescents with hyperlipidemia | Statins]] |
| #[[Hyperlipidemia NCEP guidelines for adjuvant therapies in children and adolescents | Adjuvant therapies]] | | #[[Hyperlipidemia NCEP guidelines for adjuvant therapies in children and adolescents | Adjuvant therapies]] |
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| ===[[Omega-3 fatty acids | Omega-3 Fatty Acids]]===
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| {|class="wikitable" border="1" style="width:750px"
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| |-style="background:#CDC9C9"
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| |''' Drug '''
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| |''' Mechanisms of Benefit '''
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| |''' Dosage '''
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| |''' Advantages '''
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| |''' Side Effects '''
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| |''' Contraindications '''
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| |-
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| | '''Omega-3 fatty acids'''
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| ↓ hepatic [[lipogenesis]]<br>↓ plasma [[lipoprotein lipase]] activity<br>↑ hepatic mitochondrial and peroxisomal [[beta-oxidation]]<br>Inhibition of acyl CoA:1,2-[[diacylglycerol acyltransferase]] enzyme<br>[[EPA]] and [[DHA]] are poor enzyme substrates for [[triglyceride]] synthesis in [[liver]] and inhibits esterification of other fatty acids.
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| 3 g/day of EPA and DHA<ref name="pmid16825676">{{cite journal| author=Wang C, Harris WS, Chung M, Lichtenstein AH, Balk EM, Kupelnick B et al.| title=n-3 Fatty acids from fish or fish-oil supplements, but not alpha-linolenic acid, benefit cardiovascular disease outcomes in primary- and secondary-prevention studies: a systematic review. | journal=Am J Clin Nutr | year= 2006 | volume= 84 | issue= 1 |pages= 5-17 | pmid=16825676 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16825676 }} </ref>
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| ↓ [[VLDL]]<ref name="pmid6736254">{{cite journal| author=Nestel PJ, Connor WE, Reardon MF, Connor S, Wong S, Boston R| title=Suppression by diets rich in fish oil of very low density lipoprotein production in man. | journal=J Clin Invest | year= 1984 | volume= 74 | issue= 1 | pages= 82-9 | pmid=6736254 | doi=10.1172/JCI111422 | pmc=PMC425187 | url=}} </ref>, <ref name="pmid11303007">{{cite journal| author=Durrington PN, Bhatnagar D, Mackness MI, Morgan J, Julier K, Khan MA et al.| title=An omega-3 polyunsaturated fatty acid concentrate administered for one year decreased triglycerides in simvastatin treated patients with coronary heart disease and persisting hypertriglyceridaemia. |journal=Heart | year= 2001 | volume= 85 | issue= 5 | pages= 544-8 | pmid=11303007 | doi= | pmc=PMC1729738 | url= }}</ref><br>↓ [[TG]] by ≥50%
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| [[Bleeding]], at high doses<br>
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| Fishy smell, can be reduced by
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| *freezing of medication
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| *trying different formulation
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| *taking medication with food
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| [[Nausea]]
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| Hypersensitivity
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| |} (↑ - Increase, ↓ - Decrease)
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| ==References== | | ==References== |