Hyperlipoproteinemia laboratory findings
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Lipoprotein Disorders Microchapters |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Laboratory Findings
Complete lipid profile
The US National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) suggests screening asymptomatic individuals with a complete fasting lipid profile every 5 years. Obtain complete lipid profile after 9 to 12-hour fast. The reference values according to ATP III classification for making the diagnosis and risk stratification are depicted below:
| Levels of total cholesterol (mg/dl) | |
| < 200 | Desirable |
| 200 - 239 | Borderline high |
| ≥ 240 | High |
| Levels of LDL cholesterol (mg/dl) | |
| < 100 | Optimal |
| 100 - 129 | Near optimal |
| 130 - 159 | Borderline high |
| 160 - 189 | High |
| ≥ 190 | Very high |
| Levels of HDL Cholesterol (mg/dl) | |
| < 40 | Low |
| ≥ 60 | High |
| Levels of serum triglycerides (mg/dl) | |
| < 150 | Normal |
| 150 - 199 | Borderline high |
| 200 - 499 | High |
| ≥ 500 | Very high |
Other laboratory tests
For careful medical evaluation, must take into consideration all medications (both prescription and over-the-counter medications) and perform following tests to rule out secondary hyperlipidemias:
- Serum thyroid-stimulating hormone
- Liver function tests
- Serum creatinine
- Urinalysis
Other tests that may be done include: Studies of cells called fibroblasts to see how the body absorbs LDL cholesterol Gene or receptor analysis for the defect associated with this condition.
Approach
| Hyperlipidemia | |||||||||||||||||||||||||||||||||||||||||
| Triglycerides > 75th Percentile | NO | Type IIa | |||||||||||||||||||||||||||||||||||||||
| YES | |||||||||||||||||||||||||||||||||||||||||
| Types I, IIb, IV, V | |||||||||||||||||||||||||||||||||||||||||
| Total Cholesterol/Apo B ratio ≥ 6.2 | NO | Types IIb, IV | |||||||||||||||||||||||||||||||||||||||