High density lipoprotein overview: Difference between revisions
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Most [[clinical trials]] on prevention of [[coronary artery disease]] focus on lowering the levels of [[LDL]] cholesterol in the blood using [[statins]] and other lipid lowering drugs. These have shown improved clinical outcomes and reduction in mortality. | Most [[clinical trials]] on prevention of [[coronary artery disease]] focus on lowering the levels of [[LDL]] cholesterol in the blood using [[statins]] and other lipid lowering drugs. These have shown improved clinical outcomes and reduction in mortality. | ||
However, a causal relationship between low [[HDL]] cholesterol levels and development of significant [[coronary artery disease]] has not been established. There is a lack of evidence for proving that raising [[HDL]] levels can reduce cardiovascular events in those with coronary artery disease. [[Statin]]s are used in treatment of patients with low [[HDL]] levels to reduce the levels of "bad" [[LDL]] cholesterol in the blood <ref name="pmid23420445">{{cite journal |author=Rubenfire M, Brook RD |title=HDL cholesterol and cardiovascular outcomes: what is the evidence? |journal=[[Current Cardiology Reports]] |volume=15 |issue=4 |pages=349 |year=2013 |month=April |pmid=23420445 |doi=10.1007/s11886-013-0349-3 |url=}}</ref> <ref name="pmid23406187">{{cite journal |author=Ginter E, Simko V |title=New promising potential in fighting atherosclerosis: HDL and reverse cholesterol transport |journal=[[Bratislavské Lekárske Listy]] |volume=114 |issue=3 |pages=172–6 |year=2013 |pmid=23406187 |doi= |url=}}</ref>. | However, a causal relationship between low [[HDL]] cholesterol levels and development of significant [[coronary artery disease]] has not been established. There is a lack of evidence for proving that raising [[HDL]] levels can reduce cardiovascular events in those with [[coronary artery disease]]. [[Statin]]s are used in treatment of patients with low [[HDL]] levels to reduce the levels of "bad" [[LDL]] cholesterol in the blood <ref name="pmid23420445">{{cite journal |author=Rubenfire M, Brook RD |title=HDL cholesterol and cardiovascular outcomes: what is the evidence? |journal=[[Current Cardiology Reports]] |volume=15 |issue=4 |pages=349 |year=2013 |month=April |pmid=23420445 |doi=10.1007/s11886-013-0349-3 |url=}}</ref> <ref name="pmid23406187">{{cite journal |author=Ginter E, Simko V |title=New promising potential in fighting atherosclerosis: HDL and reverse cholesterol transport |journal=[[Bratislavské Lekárske Listy]] |volume=114 |issue=3 |pages=172–6 |year=2013 |pmid=23406187 |doi= |url=}}</ref>. | ||
==References== | ==References== | ||
Revision as of 14:54, 14 April 2013
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High Density Lipoprotein Microchapters |
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Diagnosis |
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Treatment |
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Clinical Trials |
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Case Studies |
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High density lipoprotein overview On the Web |
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American Roentgen Ray Society Images of High density lipoprotein overview |
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Risk calculators and risk factors for High density lipoprotein overview |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aarti Narayan, M.B.B.S [2]; Raviteja Guddeti, M.B.B.S. [3]
Overview
High-density lipoproteins form a class of lipoproteins, varying somewhat in their size (8–11 nm in diameter), that carry cholesterol from the body's tissues to the liver. About thirty percent of blood cholesterol is carried by HDL.[1]
It is hypothesized that HDL can remove cholesterol from atheroma within arteries and transport it back to the liver for excretion or re-utilization— which is the main reason why HDL-bound cholesterol is sometimes called "good cholesterol", or HDL-C. A high level of HDL-C seems to protect against cardiovascular diseases, and low HDL cholesterol levels (less than 40 mg/dL) increase the risk for heart disease. When measuring cholesterol, any contained in HDL particles is considered as protection to the body's cardiovascular health, in contrast to "bad" LDL cholesterol.
Most clinical trials on prevention of coronary artery disease focus on lowering the levels of LDL cholesterol in the blood using statins and other lipid lowering drugs. These have shown improved clinical outcomes and reduction in mortality.
However, a causal relationship between low HDL cholesterol levels and development of significant coronary artery disease has not been established. There is a lack of evidence for proving that raising HDL levels can reduce cardiovascular events in those with coronary artery disease. Statins are used in treatment of patients with low HDL levels to reduce the levels of "bad" LDL cholesterol in the blood [2] [3].
References
- ↑ http://www.americanheart.org/presenter.jhtml?identifier=180
- ↑ Rubenfire M, Brook RD (2013). "HDL cholesterol and cardiovascular outcomes: what is the evidence?". Current Cardiology Reports. 15 (4): 349. doi:10.1007/s11886-013-0349-3. PMID 23420445. Unknown parameter
|month=ignored (help) - ↑ Ginter E, Simko V (2013). "New promising potential in fighting atherosclerosis: HDL and reverse cholesterol transport". Bratislavské Lekárske Listy. 114 (3): 172–6. PMID 23406187.