High cholesterol primary prevention: Difference between revisions
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== | ==LDL lowering drug therapy== | ||
==References== | ==References== | ||
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Revision as of 03:01, 9 September 2011
Primary prevention is the most effective means of reducing the global burden of cardiovascular disease. NCEP recommends population-based and clinical-based approaches for primary prevention. Physicians should establish short-term and long-term goals for their patients based on risk factors and 10-year CHD risk. Two-step approach is preferred:
Therapeutic lifestyle changes
Therapeutic lifestyle changes should be recommended to every individual to reduce long-term risk. These include cessation of smoking, dietary modifications, weight control and physical inactivity. A previous meta-analysis showed that dietary lowering of cholesterol was associated with CHD risk reduction similar to drug therapy[1]. A recent randomized controlled trial by Jenkins et al. showed that cholesterol lowering diets were associated with a significant reduction in LDL and 10-year CHD risk at 6 monhts, as compared to control diet[2].
LDL lowering drug therapy
References
- ↑ Gordon DJ.Cholesterol lowering reduces mortality:the statins. In: Grundy SM, ed. Cholesterol-lowering therapy: evaluation of clinical trial evidence. New York:Marcel Dekker Inc., 2000:299-311
- ↑ Jenkins DJ, Jones PJ, Lamarche B, Kendall CW, Faulkner D, Cermakova L; et al. (2011). "Effect of a dietary portfolio of cholesterol-lowering foods given at 2 levels of intensity of dietary advice on serum lipids in hyperlipidemia: a randomized controlled trial". JAMA. 306 (8): 831–9. doi:10.1001/jama.2011.1202. PMID 21862744.