Hepatotoxicity epidemiology and demographics: Difference between revisions

Jump to navigation Jump to search
(Created page with "__NOTOC__ {{Hepatotoxicity}} {{CMG}} ==Overview== ==Epidemiology== ==References== {{Reflist|2}} Category:Disease Category:Hepatology Category:Toxicology [...")
 
mNo edit summary
Line 9: Line 9:
==Epidemiology==
==Epidemiology==


Drug-related hepatotoxicity is generally considered as an uncommon complication for many drugs, with an incidence between 1 in 10,000 and 1 in 100,000.<ref name="Larrey-2002">{{Cite journal  | last1 = Larrey | first1 = D. | title = Epidemiology and individual susceptibility to adverse drug reactions affecting the liver. | journal = Semin Liver Dis | volume = 22 | issue = 2 | pages = 145-55 | month =  | year = 2002 | doi = 10.1055/s-2002-30105 | PMID = 12016546 }}</ref> The incidence of hepatotoxicity is hard to determine, partly because of difficulties in detection as well as the lack of unified criteria for diagnosis.


One study from France reported a crude annual incidence of 13.9 ± 2.4 per 100,000 inhabitants, which is 16 times greater than the number noted by spontaneous reporting to French regulatory authorities. The true incidence of hepatic adverse events in the general population remains unknown and is often underestimated.<ref name="Larrey-2002">{{Cite journal  | last1 = Larrey | first1 = D. | title = Epidemiology and individual susceptibility to adverse drug reactions affecting the liver. | journal = Semin Liver Dis | volume = 22 | issue = 2 | pages = 145-55 | month =  | year = 2002 | doi = 10.1055/s-2002-30105 | PMID = 12016546 }}</ref>


==References==
==References==

Revision as of 20:17, 11 February 2014

Hepatotoxicity Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Hepatotoxicity from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms

Physical Examination

Laboratory Findings

X Ray

CT

MRI

Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Hepatotoxicity epidemiology and demographics On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Hepatotoxicity epidemiology and demographics

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Hepatotoxicity epidemiology and demographics

CDC on Hepatotoxicity epidemiology and demographics

Hepatotoxicity epidemiology and demographics in the news

Blogs on Hepatotoxicity epidemiology and demographics

Directions to Hospitals Treating Hepatotoxicity

Risk calculators and risk factors for Hepatotoxicity epidemiology and demographics

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Epidemiology

Drug-related hepatotoxicity is generally considered as an uncommon complication for many drugs, with an incidence between 1 in 10,000 and 1 in 100,000.[1] The incidence of hepatotoxicity is hard to determine, partly because of difficulties in detection as well as the lack of unified criteria for diagnosis.

One study from France reported a crude annual incidence of 13.9 ± 2.4 per 100,000 inhabitants, which is 16 times greater than the number noted by spontaneous reporting to French regulatory authorities. The true incidence of hepatic adverse events in the general population remains unknown and is often underestimated.[1]

References

  1. 1.0 1.1 Larrey, D. (2002). "Epidemiology and individual susceptibility to adverse drug reactions affecting the liver". Semin Liver Dis. 22 (2): 145–55. doi:10.1055/s-2002-30105. PMID 12016546.