Hemophilia historical perspective: Difference between revisions
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==Overview== | ==Overview== | ||
==Historical Perspective== | ==Historical Perspective== | ||
The first | The first evidence of hemophilia is in the Talmud, Jewish holy text, which states that males did not have to be circumcised if two brothers had already died from the procedure. In the 12th century, the Arab physician Albucasis wrote of a family whose males died of bleeding after minor injuries. Then, in 1803, Dr. John Conrad Otto, a Philadelphia physician, wrote an account about "a hemorrhagic disposition existing in certain families." He recognised that the disorder was hereditary and that it affected males and rarely females. He was able to trace the disease back to a woman who settled near Plymouth in 1720. The first usage of the term "hemophilia" appears in a description of the condition written by Hopff at the University of Zurich in 1828.<ref>{{cite web |url=http://www.hemophilia.ca/en/2.1.2.php |title=The History of haemophilia |accessdate=2007-06-27 |format= |work=}}</ref> In 1937, Patek and Taylor, two doctors from Harvard, discovered [[Factor VII|anti-hemophilic globulin]]. Pavlosky, a doctor from Buenos Aires, found [[Hemophilia A]] and [[Hemophilia B]] to be separate diseases by doing a lab test. This test was done by transferring the blood of one hemophiliac to another hemophiliac. The fact that this corrected the clotting problem showed that there was more than one form of hemophilia. | ||
:''See main article at [[ | :''See main article at [[Hemophilia in European royalty]]'' | ||
Hemophilia figured prominently in the history of European royalty and thus is sometimes known as "the royal disease". Queen Victoria passed the mutation to her son Leopold and, through several of her daughters, to various royals across the continent, including the royal families of Spain, Germany, and Russia. Tsarevich Alexei Nikolaevich, son of Nicholas II, was a descendant of Queen Victoria and suffered from hemophilia. | |||
Prior to 1985, there were no laws enacted to screen blood, even though the technology existed. Corporations decided that the deaths of thousands of young men were more cost efficient than the | Prior to 1985, there were no laws enacted to screen blood, even though the technology existed. Corporations decided that the deaths of thousands of young men were more cost efficient than the installation and usage of the screening equipment. As a result, many haemophilia patients who received untested and unscreened clotting factor prior to 1992 were at an extreme risk for contracting [[HIV]] and [[Hepatitis C]] via these blood products. At a rate of over 90% of the Hemophilia population, over 10,000 people contracted HIV from the tainted blood supply in the United States alone. | ||
==References== | ==References== | ||
Revision as of 20:19, 13 August 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Historical Perspective
The first evidence of hemophilia is in the Talmud, Jewish holy text, which states that males did not have to be circumcised if two brothers had already died from the procedure. In the 12th century, the Arab physician Albucasis wrote of a family whose males died of bleeding after minor injuries. Then, in 1803, Dr. John Conrad Otto, a Philadelphia physician, wrote an account about "a hemorrhagic disposition existing in certain families." He recognised that the disorder was hereditary and that it affected males and rarely females. He was able to trace the disease back to a woman who settled near Plymouth in 1720. The first usage of the term "hemophilia" appears in a description of the condition written by Hopff at the University of Zurich in 1828.[1] In 1937, Patek and Taylor, two doctors from Harvard, discovered anti-hemophilic globulin. Pavlosky, a doctor from Buenos Aires, found Hemophilia A and Hemophilia B to be separate diseases by doing a lab test. This test was done by transferring the blood of one hemophiliac to another hemophiliac. The fact that this corrected the clotting problem showed that there was more than one form of hemophilia.
- See main article at Hemophilia in European royalty
Hemophilia figured prominently in the history of European royalty and thus is sometimes known as "the royal disease". Queen Victoria passed the mutation to her son Leopold and, through several of her daughters, to various royals across the continent, including the royal families of Spain, Germany, and Russia. Tsarevich Alexei Nikolaevich, son of Nicholas II, was a descendant of Queen Victoria and suffered from hemophilia.
Prior to 1985, there were no laws enacted to screen blood, even though the technology existed. Corporations decided that the deaths of thousands of young men were more cost efficient than the installation and usage of the screening equipment. As a result, many haemophilia patients who received untested and unscreened clotting factor prior to 1992 were at an extreme risk for contracting HIV and Hepatitis C via these blood products. At a rate of over 90% of the Hemophilia population, over 10,000 people contracted HIV from the tainted blood supply in the United States alone.
References
- ↑ "The History of haemophilia". Retrieved 2007-06-27.