Hemoglobinopathy: Difference between revisions
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===Prevalence=== | ===Prevalence=== | ||
*In 2008, the prevalence of hemoglobinopathy was estimated to be 7% of the worldwide population being carrier.<ref name=" | *In 2008, the prevalence of hemoglobinopathy was estimated to be 7% of the worldwide population being carrier.<ref name="pmid21886666">{{cite journal |vauthors=Kohne E |title=Hemoglobinopathies: clinical manifestations, diagnosis, and treatment |journal=Dtsch Arztebl Int |volume=108 |issue=31-32 |pages=532–40 |date=August 2011 |pmid=21886666 |pmc=3163784 |doi=10.3238/arztebl.2011.0532 |url=}}</ref> | ||
===Race=== | ===Race=== | ||
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* Hb M | * Hb M | ||
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[[Category:Hematology]] | [[Category:Hematology]] | ||
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Revision as of 18:09, 31 August 2018
Template:Search infobox Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sogand Goudarzi, MD [2]
Overview
Hemoglobinopathy is a kind of genetic defect that results in abnormal structure of one of the globin chains of the hemoglobin molecule. Most common hemoglobinopathies include sickle-cell disease.
Classification
Hemoglobinopathy be classified according to genetic and structure of hemoglobin into two main groups:
- Thalassemia syndromes
- α-thalassemia
- β-thalassemia
- Structural hemoglobin variants
- HbS
- HbE
- HbC
- Hb Bart’s
- Hb J(Johnstown)
- HbM
- HbX
- Hb D
Migration patterns
Epidemiology and Demographics
Incidence
- The incidence/prevalence of [disease name] is approximately [number range] per 100,000 individuals worldwide.
- In [year], the incidence/prevalence of [disease name] was estimated to be [number range] cases per 100,000 individuals worldwide.[1]
Prevalence
- In 2008, the prevalence of hemoglobinopathy was estimated to be 7% of the worldwide population being carrier.[1]
Race
α-thalassemias
It occure cur mainly in Africa, Arab nations, and, more frequently and South-East Asia.
β-thalassemias
It occure cur mainly in Mediterranean countries, South-East Europe, Arab nations and Asia.
Screening
Common variants
- Hb S
- Hb C
- Hb E
- Hb D-Punjab
- Hb O-Arab
- Hb G-Philadelphia
- Hb Hasharon
- Hb Korle-Bu
- Hb Lepore
- Hb M
References
- ↑ 1.0 1.1 Kohne E (August 2011). "Hemoglobinopathies: clinical manifestations, diagnosis, and treatment". Dtsch Arztebl Int. 108 (31–32): 532–40. doi:10.3238/arztebl.2011.0532. PMC 3163784. PMID 21886666.