Hemoglobinopathy: Difference between revisions

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==Classification==
==Classification==
Hemoglobinopathy be classified according to genetic and structure of hemoglobin into two main groups:<ref name="pmid218866662">{{cite journal |vauthors=Kohne E |title=Hemoglobinopathies: clinical manifestations, diagnosis, and treatment |journal=Dtsch Arztebl Int |volume=108 |issue=31-32 |pages=532–40 |date=August 2011 |pmid=21886666 |pmc=3163784 |doi=10.3238/arztebl.2011.0532 |url=}}</ref>
Hemoglobinopathy be classified according to genetic and structure of hemoglobin into two main groups:<ref name="pmid17950634">{{cite journal |vauthors=Petrides PE, Beykirch MK, Kohne E |title=The high oxygen-affinity Hemoglobin Johnstown [(beta 109(G11) Val-->Leu] in a German kindred with an elevated erythrocyte hemoglobin content: potential interaction with HFE mutations |journal=Blood Cells Mol. Dis. |volume=40 |issue=2 |pages=180–2 |date=2008 |pmid=17950634 |doi=10.1016/j.bcmd.2007.08.007 |url=}}</ref>
* Thalassemia syndromes  
* Thalassemia syndromes  
**α-thalassemia
**α-thalassemia
Line 17: Line 17:
** HbC
** HbC
** Hb Bart’s  
** Hb Bart’s  
** Hb J(Johnstown)
** HbM 
** HbX
** HbX
** Hb D
** Hb D

Revision as of 15:32, 31 August 2018

Template:Search infobox Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sogand Goudarzi, MD [2]


Overview

Hemoglobinopathy is a kind of genetic defect that results in abnormal structure of one of the globin chains of the hemoglobin molecule. Most common hemoglobinopathies include sickle-cell disease.

Classification

Hemoglobinopathy be classified according to genetic and structure of hemoglobin into two main groups:[1]

  • Thalassemia syndromes
    • α-thalassemia
    • β-thalassemia
  • Structural hemoglobin variants
    • HbS
    • HbE
    • HbC
    • Hb Bart’s
    • Hb J(Johnstown)
    • HbM
    • HbX
    • Hb D


Migration patterns

Epidemiology and Demographics

Incidence

  • The incidence/prevalence of [disease name] is approximately [number range] per 100,000 individuals worldwide.
  • In [year], the incidence/prevalence of [disease name] was estimated to be [number range] cases per 100,000 individuals worldwide.

Prevalence

  • In 2008, the prevalence of hemoglobinopathy was estimated to be 7% of the worldwide population being carrier.

α-thalassemias

It occure cur mainly in Africa, Arab nations, and, more frequently and South-East Asia

β-thalassemias

It occure cur mainly in Mediterranean countries, South-East Europe, Arab nations and Asia.

Common variants

  • Hb S
  • Hb C
  • Hb E
  • Hb D-Punjab
  • Hb O-Arab
  • Hb G-Philadelphia
  • Hb Hasharon
  • Hb Korle-Bu
  • Hb Lepore
  • Hb M

Hemoglobinopathy and evolution

de:Hämoglobinopathie nl:Hemoglobinopathie

Template:Hematology


Template:WikiDoc Sources

  1. Petrides PE, Beykirch MK, Kohne E (2008). "The high oxygen-affinity Hemoglobin Johnstown [(beta 109(G11) Val-->Leu] in a German kindred with an elevated erythrocyte hemoglobin content: potential interaction with HFE mutations". Blood Cells Mol. Dis. 40 (2): 180–2. doi:10.1016/j.bcmd.2007.08.007. PMID 17950634.