Headache pathophysiology: Difference between revisions
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==Pathophysiology== | ==Pathophysiology== | ||
===Physiology=== | ===Physiology=== | ||
The normal | *The normal pathophysiology of can be understood as follows: | ||
*vascular dilation,trigeminal nerve stimulation and histamine release.<ref name="pmid23939643">{{cite journal| author=Weaver-Agostoni J| title=Cluster headache. | journal=Am Fam Physician | year= 2013 | volume= 88 | issue= 2 | pages= 122-8 | pmid=23939643 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23939643 }} </ref> | |||
===Pathogenesis=== | ===Pathogenesis=== | ||
Revision as of 00:38, 15 April 2021
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Headache Microchapters |
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Headache pathophysiology On the Web |
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American Roentgen Ray Society Images of Headache pathophysiology |
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Risk calculators and risk factors for Headache pathophysiology |
Editor-In-Chief: Robert G. Schwartz, M.D. [1], Piedmont Physical Medicine and Rehabilitation, P.A.; Associate Editor-In-Chief: Cafer Zorkun, M.D., Ph.D. [2]
Overview
The brain in itself is not sensitive to pain, because it lacks pain-sensitive nerve fibers. Several areas of the head can hurt, including a network of nerves which extend over the scalp and certain nerves in the face, mouth, and throat. The meninges and the blood vessels do have pain perception. Headaches often result from traction to or irritation of the meninges and blood vessels. The muscles of the head may similarly be sensitive to pain.
Pathophysiology
Physiology
- The normal pathophysiology of can be understood as follows:
- vascular dilation,trigeminal nerve stimulation and histamine release.[1]
Pathogenesis
- The exact pathophysiology of cluster headache is not completely understood.
- It is understood that cluster headache is caused by either vascular dilation,trigeminal nerve stimulation and histamine release.
Genetics
Genes involved in the pathogenesis of migraine include:
- MTDH
- LRP1
- TRPM8
The development of familial hemiplegic migraine is the result of multiple genetic mutations such as:
- CACNA1A
- ATP1A2
- SCN1A[2]
References
- ↑ Weaver-Agostoni J (2013). "Cluster headache". Am Fam Physician. 88 (2): 122–8. PMID 23939643.
- ↑ Andreou AP, Edvinsson L (2019). "Mechanisms of migraine as a chronic evolutive condition". J Headache Pain. 20 (1): 117. doi:10.1186/s10194-019-1066-0. PMC 6929435 Check
|pmc=value (help). PMID 31870279.