Headache differential diagnosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Sabeeh Islam, MBBS[2]


Disease History and Physical Examination PMHx Diagnostic approach
Unilateral Bilateral Throbbing character Autonomic symptoms Fever Photophobia Aphasia LOC Aura Nause/vomiting Rash Neck stiffness Vision changes Facial tenderness Neurologic deficits Labs and CSF findings CT/MRI Gold standard test
Migraine + - + - - + - - + + - - + - - Trigger factors, family hx - - Clinical assesment
Tension-type headache (TTH) - + - - - - - - - - - - - - - stress, genetics - - Clinical assesment
Cluster headache + - - + - - - - - - - - + - - episodic history - - Clinical assesment
Seizure - + - - - - +/- + +/- - - - - - +/- Hx of seizures prolactin level +/- mass lesion EEG
Meningitis - + - - + +/- +/- - - +/- +/- + - - + Hx of fever, malaise <math>\uparrow</math>WBC

<math>\uparrow</math>Protein

<math>\downarrow</math>glucose

+/- CSF analysis
Encephalitis - + +/- - + +/- +/- - - - +/- + - - + Hx of fever, malaise elevated WBC, low glucose + CSF PCR
Brain tumor - + - - - - +/- - - +/- - - +/- - +/- weight loss, fatigue neuromarkers +/- mass MRI
Subdural hemorrhage -/+ -/+ +/- - - - +/- - - - - - +/- - +/- Trauma, fall Xanthochromia + CT w/o contrast
Subarachnoid hemorrhage -/+ + +/- - - +/- +/- - - - - +/- +/- - +/- thunderclap headache <math>\uparrow</math>opening pressure, xanthochromia + CT w/o contrast
Hypertensive encephalopathy - + +/- - - +/- - - - - - - +/- - - Hypertension UA +/- +/- clinical assessment
CNS abscess -/+ -/+ - - + - +/- - - +/- +/- +/- +/- - +/- History of drug abuse, endocarditis, immunosupression leukocytes, glucose and protien + MRI
Conversion disorder -/+ -/+ - - - - +/- - - - - +/- +/- - +/- History of emotional stress - - Diagnosis of exclusion
Multiple sclerosis -/+ -/+ - - - - - - - - - - + - +/- History of relapses and remissions CSF IgG levels

(monoclonal bands)

+ MRI
Hemorrhagic stroke -/+ -/+ +/- - - - +/- - - - - - +/- - +/- HTN - + CT scan without contrast[1][2]
Neurosyphilis -/+ -/+ - - - - - +/- - - +/- - +/- - +/- STIs Leukocytes and protein + CSF VDRL-specifc

CSF FTA-Ab -sensitive[3]

Wernicke’s encephalopathy - -/+ - - - - +/- - - - - - +/- - +/- History of alcohal abuse blood ethanol levels +/- Clinical assesment and lab findings
Drug toxicity - -/+ - - +/- - - +/- - +/- - +/- +/- - +/- Medication hx Drug levels - Drug screen test
Metabolic disturbances - -/+ - - - - - - - +/- - - +/- - +/- Underlying CKD, CLD Hypoglycemia, hypo and hypernatremia, hypo and hyperkalemia - Cause dependent
NPH - -/+ - - - - - - - - - - +/- - - OCP use, meds - +/- CT and clinical
Sinusitis - -/+ - - +/- - - - - - - - - - - allergies, seasonal leukocytosis + CT

References

  1. Birenbaum D, Bancroft LW, Felsberg GJ (2011). "Imaging in acute stroke". West J Emerg Med. 12 (1): 67–76. PMC 3088377. PMID 21694755.
  2. DeLaPaz RL, Wippold FJ, Cornelius RS, Amin-Hanjani S, Angtuaco EJ, Broderick DF; et al. (2011). "ACR Appropriateness Criteria® on cerebrovascular disease". J Am Coll Radiol. 8 (8): 532–8. doi:10.1016/j.jacr.2011.05.010. PMID 21807345.
  3. Ho EL, Marra CM (2012). "Treponemal tests for neurosyphilis--less accurate than what we thought?". Sex Transm Dis. 39 (4): 298–9. doi:10.1097/OLQ.0b013e31824ee574. PMC 3746559. PMID 22421697.


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