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==Pathophysiology==
==Pathophysiology==
A few theories are proposed for Hashimoto encephalopathy.
A few theories are proposed for Hashimoto encephalopathy.



Revision as of 20:41, 24 July 2012

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Articles on Hashimoto's encephalopathy in N Eng J Med, Lancet, BMJ

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Hashimoto's Encephalopathy is a very rare condition associated with Hashimoto's Thyroiditis. Hashimoto's Encephalopathy is a neuroendocrine disorder. Much like the antibodies in Hashimoto's Thyroiditis attack the thyroid, in Hashimoto's Encephalopathy, antibodies attack neurons in the brain.

Pathophysiology

A few theories are proposed for Hashimoto encephalopathy.

  • Neuronal injury due to antibody mediated destruction.
  • Immmune complex mediated vasculitis.
  • Toxic effect of increased thyroid stimulating hormone.

Diagnosis

Symptoms

  • Headache
  • Disorientation
  • Psychosis
  • Tremors
  • Concentration and memory problems

Physical examination

  • Jerks in the muscles
  • Lack of coordination
  • Speech problems

Differential diagnosis

Treatment

Steroids or immunosuppressant treatment, this condition is now also referred to as "steroid-responsive" encephalopathy.

External links

References


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