Hantzsch pyrrole synthesis

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The Hantzch pyrrole synthesis is the chemical reaction of β-ketoesters (1) with ammonia (or primary amines) and α-haloketones (2) to give substituted pyrroles (3).[1][2]

The Hantzch pyrrole synthesis
The Hantzch pyrrole synthesis

References

  1. Hantzsch, A. Ber. 1890, 23, 1474.
  2. Feist, F. Ber. 1902, 35, 1538.

See also


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