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| {{DiseaseDisorder infobox
| | #REDIRECT [[Hemophilia B]] |
| | Name = Haemophilia B
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| | ICD10 = {{ICD10|D|67||d|65}}
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| | ICD9 = {{ICD9|286.1}}
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| | ICDO =
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| | Image =
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| | Caption =
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| | OMIM = 306900
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| | MedlinePlus = 000539
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| | eMedicineSubj = emerg
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| | eMedicineTopic = 240
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| | DiseasesDB = 5561
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| | MeshID = D002836
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| }}
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| {{Search infobox}}
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| {{CMG}}
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| {{Editor Help}}
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| ==Overview==
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| '''Haemophilia B''' (also spelled '''Hemophilia B''' or '''Hæmophilia B''') is a [[coagulation|blood clotting]] disorder caused by a [[mutation]] of the [[Factor IX]] [[gene]]. It is the second most common form of [[haemophilia]], rarer than [[haemophilia A]]. It is sometimes called '''Christmas disease''' after Stephen Christmas, the first patient described with this disease.<ref>{{WhoNamedIt|synd|2321|Christmas' disease}}</ref> In addition, the first report of its identification was published in the Christmas edition of the [[British Medical Journal]].<ref>Biggs RA, Douglas AS, MacFarlane RG, Dacie JV, Pittney WR, Merskey C, O'Brien JR. ''Christmas disease: a condition previously mistaken for haemophilia.'' [[British Medical Journal|Br Med J]] 1952;2:1378-1382. PMID 12997790.</ref>
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| ==Treatment==
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| Treatment (bleeding prophylaxis) is by intravenous infusion of factor IX.
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| ==Genetics==
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| The factor IX gene is located on the [[X chromosome]] (Xq27.1-q27.2). It is inherited [[X-linked]] recessive, which explains why - as in haemophilia A - mostly males are generally affected.
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| ==Pathophysiology==
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| Factor IX deficiency leads to an increased propensity for [[haemorrhage]]. This is in response to mild trauma or even spontaneously, such as in joints ([[hemarthrosis|haemarthrosis]]) or muscles.
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| ==References==
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| <references/>
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| ==See also==
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| *[[Haemophilia]]
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| *[[Haemophilia A]]
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| *[[Haemophilia C]]
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| ==External links==
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| *[http://www.ygyh.org/hemo/whatisit.htm Haemophilia: What is it?] at [[Cold Spring Harbor Laboratory|CSHL]] ''Your Genes, Your Health''
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| *{{GPnotebook|-1529872380|haemophilia B}}
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| *{{FPnotebook|HEM17|Factor IX Deficiency}}
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| <!--Navigation boxes--><br clear=all />
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| {{Hematology}}
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| {{SIB}}
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| [[es:Hemofilia B]]
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| [[pt:Hemofilia B]]
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| [[Category:Hematology]]
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| [[Category:Genetic disorders]]
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