HU-210

HU-210

Identifiers
IUPAC name 1,1-Dimethylheptyl-11-hydroxytetrahydrocannabinol
CAS Number	112830-95-2
PubChem CID	107778
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C25H38O3
Molar mass	386.567 g/mol

WikiDoc Resources for HU-210
Articles
Most recent articles on HU-210 Most cited articles on HU-210 Review articles on HU-210 Articles on HU-210 in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on HU-210 Images of HU-210 Photos of HU-210 Podcasts & MP3s on HU-210 Videos on HU-210
Evidence Based Medicine
Cochrane Collaboration on HU-210 Bandolier on HU-210 TRIP on HU-210
Clinical Trials
Ongoing Trials on HU-210 at Clinical Trials.gov Trial results on HU-210 Clinical Trials on HU-210 at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on HU-210 NICE Guidance on HU-210 NHS PRODIGY Guidance FDA on HU-210 CDC on HU-210
Books
Books on HU-210
News
HU-210 in the news Be alerted to news on HU-210 News trends on HU-210
Commentary
Blogs on HU-210
Definitions
Definitions of HU-210
Patient Resources / Community
Patient resources on HU-210 Discussion groups on HU-210 Patient Handouts on HU-210 Directions to Hospitals Treating HU-210 Risk calculators and risk factors for HU-210
Healthcare Provider Resources
Symptoms of HU-210 Causes & Risk Factors for HU-210 Diagnostic studies for HU-210 Treatment of HU-210
Continuing Medical Education (CME)
CME Programs on HU-210
International
HU-210 en Espanol HU-210 en Francais
Business
HU-210 in the Marketplace Patents on HU-210
Experimental / Informatics
List of terms related to HU-210

Overview

HU-210 is a synthetic cannabinoid that was discovered around 1988 in the group of Dr Raphael Mechoulam at the Hebrew University. HU-210 is 100 to 800 times more potent than natural THC from cannabis and has an extended duration of action.[1] HU-210 is the (+)-1,1-dimethylheptyl analog of 7-hydroxy-delta-6-tetrahydrocannabinol. The abbreviation HU stands for Hebrew University.

Per a 2005 article in the Journal Of Clinical Investigation, HU-210 with daily high doses over a few weeks stimulates neural growth in rats' hippocampus region, the opposite effect of drugs like alcohol, nicotine, heroin, and cocaine. It was also indicated by this increased neural growth to entail antianxiety and antidepressant effects.

HU-210, along side WIN 55,212-2 and JWH-133, is implicated in preventing the inflammation caused by Amyloid beta proteins involved in Alzheimer's Disease, in addition to preventing cognitive impairment and loss of neuronal markers. This anti-inflammatory action is induced through the agonization of cannabinoid receptors which prevents microglial activation that elicits the inflammation. Additionally, cannabinoids completely abolish neurotoxicity related to microglia activation in rat models.

HU-210 is a potent analgesic with many of the same effects as natural THC. This means that HU-210 could potentially be used in medicine as an alternative to medical marijuana, however its much stronger and longer lasting effects compared to those of THC could make appropriate titration of dosage difficult. Also because HU-210 is a CB₁ full agonist as opposed to THC which is a partial agonist, the sedative effects of HU-210 are much more prominent, meaning that while fatal overdoses of THC itself are virtually impossible[2], they would be possible with HU-210.

External links

• Wen Jiang; et al. (2005). "Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic and antidepressant-like effects". The Journal of Clinical Investigation.CS1 maint: Explicit use of et al. (link) Scientific article about nerve cell growth.
  • Geoff Brumfiel (2005). "Marijuana may make your brain grow. Cannabinoid injections sprout new neurons in mice". Nature.

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• Belén G. Ramírez, Cristina Blázquez, Teresa Gómez del Pulgar, Manuel Guzmán, and María L. de Ceballos (2005). "Prevention of Alzheimer's Disease Pathology by Cannabinoids: Neuroprotection Mediated by Blockade of Microglial Activation". The Journal of Neuroscience.CS1 maint: Multiple names: authors list (link)

• Science News: High Times for Brain Growth: Marijuana-like drug multiplies neurons