HIV associated nephropathy natural history, complications and prognosis: Difference between revisions
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==Natural History== | ==Natural History== | ||
If left untreated, HIV-associated nephropathy will progress to end-stage renal disease in a few weeks to months. | |||
==Complications== | ==Complications== | ||
Possible complications that are associated with HIV-associated nephropathy include: | |||
==Prognosis== | ==Prognosis== | ||
In the past, before the advent of HAART therapy, the prognosis of HIV-associated nephropathy was fatal. The mortality rate during this time was 100% within 6 months. Today, the prognosis with the availability of HAART therapy still remains grim, however, its availability has increased renal survival rate. | |||
'''The following are favorable prognostic factors:''' | |||
* Patients on HAART therapy | |||
* Patients with low-grade proteinuria | |||
* Patients who have a suppressed HIV-1 viral load | |||
* Patients who express a normal renal echogenicity | |||
* Patients with CD4 levels that between 200 and 500 cells/mm<sup>3</sup> | |||
* Patients who have higher estimated glomerular filtration rates | |||
'''The following are poor prognostics factors:''' | |||
* Patients not receiving HAART therapy | |||
* Patients with high-grade proteinuria | |||
* Patients who have under suppressed HIV-1 viral load | |||
* Patients who express a large renal echogenicity | |||
* Patients who have CD4 levels that are below 200 cells/mm<sup>3</sup> | |||
* Patients who have lower estimated glomerular filtration rates | |||
The current first and second year survival rate of HIV-associated nephropathy is estimated to be around 63% and 43% respectively, with the use of HAART therapy. | |||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} |
Revision as of 12:08, 20 December 2016
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Ali Poyan Mehr, M.D. [2];Associate Editor(s)-in-Chief: Krzysztof Wierzbicki M.D. [3]
Natural History
If left untreated, HIV-associated nephropathy will progress to end-stage renal disease in a few weeks to months.
Complications
Possible complications that are associated with HIV-associated nephropathy include:
Prognosis
In the past, before the advent of HAART therapy, the prognosis of HIV-associated nephropathy was fatal. The mortality rate during this time was 100% within 6 months. Today, the prognosis with the availability of HAART therapy still remains grim, however, its availability has increased renal survival rate.
The following are favorable prognostic factors:
- Patients on HAART therapy
- Patients with low-grade proteinuria
- Patients who have a suppressed HIV-1 viral load
- Patients who express a normal renal echogenicity
- Patients with CD4 levels that between 200 and 500 cells/mm3
- Patients who have higher estimated glomerular filtration rates
The following are poor prognostics factors:
- Patients not receiving HAART therapy
- Patients with high-grade proteinuria
- Patients who have under suppressed HIV-1 viral load
- Patients who express a large renal echogenicity
- Patients who have CD4 levels that are below 200 cells/mm3
- Patients who have lower estimated glomerular filtration rates
The current first and second year survival rate of HIV-associated nephropathy is estimated to be around 63% and 43% respectively, with the use of HAART therapy.