HIF1AN: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Hypoxia-inducible factor 1-alpha inhibitor''' is a [[protein]] that in humans is encoded by the ''HIF1AN'' [[gene]].<ref name="pmid11641274">{{cite journal | vauthors = Mahon PC, Hirota K, Semenza GL | title = FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity | journal = Genes Dev | volume = 15 | issue = 20 | pages = 2675–86 | date = Oct 2001 | pmid = 11641274 | pmc = 312814 | doi = 10.1101/gad.924501 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: HIF1AN hypoxia-inducible factor 1, alpha subunit inhibitor| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55662| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image = PBB_Protein_HIF1AN_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1h2k.
| PDB = {{PDB2|1h2k}}, {{PDB2|1h2l}}, {{PDB2|1h2m}}, {{PDB2|1h2n}}, {{PDB2|1iz3}}, {{PDB2|1mze}}, {{PDB2|1mzf}}, {{PDB2|1yci}}, {{PDB2|2cgn}}, {{PDB2|2cgo}}
| Name = Hypoxia-inducible factor 1, alpha subunit inhibitor
| HGNCid = 17113
| Symbol = HIF1AN
| AltSymbols =; DKFZp762F1811; FIH1; FLJ20615; FLJ22027
| OMIM = 606615
| ECnumber = 
| Homologene = 9906
| MGIid = 2442345
| GeneAtlas_image1 = PBB_GE_HIF1AN_218525_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_HIF1AN_59999_at_tn.png
| Function = {{GNF_GO|id=GO:0004597 |text = peptide-aspartate beta-dioxygenase activity}} {{GNF_GO|id=GO:0005506 |text = iron ion binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016491 |text = oxidoreductase activity}} {{GNF_GO|id=GO:0016702 |text = oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 55662
    | Hs_Ensembl = ENSG00000166135
    | Hs_RefseqProtein = NP_060372
    | Hs_RefseqmRNA = NM_017902
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 10
    | Hs_GenLoc_start = 102285686
    | Hs_GenLoc_end = 102299745
    | Hs_Uniprot = Q9NWT6
    | Mm_EntrezGene = 319594
    | Mm_Ensembl = ENSMUSG00000036450
    | Mm_RefseqmRNA = NM_176958
    | Mm_RefseqProtein = NP_795932
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 19
    | Mm_GenLoc_start = 44616165
    | Mm_GenLoc_end = 44629585
    | Mm_Uniprot = Q8BLR9
  }}
}}
'''Hypoxia-inducible factor 1, alpha subunit inhibitor''', also known as '''HIF1AN''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: HIF1AN hypoxia-inducible factor 1, alpha subunit inhibitor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55662| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
HIF1AN has been shown to [[Protein-protein interaction|interact]] with [[HIF1A]]<ref name=pmid11641274 /> and [[Von Hippel-Lindau tumor suppressor]].<ref name=pmid11641274/>
{{PBB_Summary
| section_title =  
| summary_text =  
}}


==References==
== References ==
{{reflist|2}}
{{Reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Lando D, Peet DJ, Whelan DA, Gorman JJ, Whitelaw ML | title = Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch | journal = Science | volume = 295 | issue = 5556 | pages = 858–61 | year = 2002 | pmid = 11823643 | doi = 10.1126/science.1068592 }}
| citations =
* {{cite journal | vauthors = Freedman SJ, Sun ZY, Poy F, Kung AL, Livingston DM, Wagner G, Eck MJ | title = Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1α | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 99 | issue = 8 | pages = 5367–72 | year = 2002 | pmid = 11959990 | pmc = 122775 | doi = 10.1073/pnas.082117899 }}
*{{cite journal  | author=Mahon PC, Hirota K, Semenza GL |title=FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity. |journal=Genes Dev. |volume=15 |issue= 20 |pages= 2675-86 |year= 2001 |pmid= 11641274 |doi= 10.1101/gad.924501 }}
* {{cite journal | vauthors = Hewitson KS, McNeill LA, Riordan MV, Tian YM, Bullock AN, Welford RW, Elkins JM, Oldham NJ, Bhattacharya S, Gleadle JM, Ratcliffe PJ, Pugh CW, Schofield CJ | title = Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family | journal = J. Biol. Chem. | volume = 277 | issue = 29 | pages = 26351–5 | year = 2002 | pmid = 12042299 | doi = 10.1074/jbc.C200273200 }}
*{{cite journal | author=Lando D, Peet DJ, Whelan DA, ''et al.'' |title=Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch. |journal=Science |volume=295 |issue= 5556 |pages= 858-61 |year= 2002 |pmid= 11823643 |doi= 10.1126/science.1068592 }}
* {{cite journal | vauthors = Lando D, Peet DJ, Gorman JJ, Whelan DA, Whitelaw ML, Bruick RK | title = FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor | journal = Genes Dev. | volume = 16 | issue = 12 | pages = 1466–71 | year = 2002 | pmid = 12080085 | pmc = 186346 | doi = 10.1101/gad.991402 }}
*{{cite journal | author=Freedman SJ, Sun ZY, Poy F, ''et al.'' |title=Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alpha. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 8 |pages= 5367-72 |year= 2002 |pmid= 11959990 |doi= 10.1073/pnas.082117899 }}
* {{cite journal | vauthors = Dann CE, Bruick RK, Deisenhofer J | title = Structure of factor-inhibiting hypoxia-inducible factor 1: An asparaginyl hydroxylase involved in the hypoxic response pathway | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 99 | issue = 24 | pages = 15351–6 | year = 2003 | pmid = 12432100 | pmc = 137720 | doi = 10.1073/pnas.202614999 }}
*{{cite journal | author=Hewitson KS, McNeill LA, Riordan MV, ''et al.'' |title=Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family. |journal=J. Biol. Chem. |volume=277 |issue= 29 |pages= 26351-5 |year= 2002 |pmid= 12042299 |doi= 10.1074/jbc.C200273200 }}
* {{cite journal | vauthors = Elkins JM, Hewitson KS, McNeill LA, Seibel JF, Schlemminger I, Pugh CW, Ratcliffe PJ, Schofield CJ | title = Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alpha | journal = J. Biol. Chem. | volume = 278 | issue = 3 | pages = 1802–6 | year = 2003 | pmid = 12446723 | doi = 10.1074/jbc.C200644200 }}
*{{cite journal | author=Lando D, Peet DJ, Gorman JJ, ''et al.'' |title=FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor. |journal=Genes Dev. |volume=16 |issue= 12 |pages= 1466-71 |year= 2002 |pmid= 12080085 |doi= 10.1101/gad.991402 }}
* {{cite journal | vauthors = Lee C, Kim SJ, Jeong DG, Lee SM, Ryu SE | title = Structure of human FIH-1 reveals a unique active site pocket and interaction sites for HIF-1 and von Hippel-Lindau | journal = J. Biol. Chem. | volume = 278 | issue = 9 | pages = 7558–63 | year = 2003 | pmid = 12482756 | doi = 10.1074/jbc.M210385200 }}
*{{cite journal | author=Dann CE, Bruick RK, Deisenhofer J |title=Structure of factor-inhibiting hypoxia-inducible factor 1: An asparaginyl hydroxylase involved in the hypoxic response pathway. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 24 |pages= 15351-6 |year= 2003 |pmid= 12432100 |doi= 10.1073/pnas.202614999 }}
* {{cite journal | vauthors = Koivunen P, Hirsilä M, Günzler V, Kivirikko KI, Myllyharju J | title = Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases | journal = J. Biol. Chem. | volume = 279 | issue = 11 | pages = 9899–904 | year = 2004 | pmid = 14701857 | doi = 10.1074/jbc.M312254200 }}
*{{cite journal | author=Elkins JM, Hewitson KS, McNeill LA, ''et al.'' |title=Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alpha. |journal=J. Biol. Chem. |volume=278 |issue= 3 |pages= 1802-6 |year= 2003 |pmid= 12446723 |doi= 10.1074/jbc.C200644200 }}
* {{cite journal | vauthors = Linke S, Stojkoski C, Kewley RJ, Booker GW, Whitelaw ML, Peet DJ | title = Substrate requirements of the oxygen-sensing asparaginyl hydroxylase factor-inhibiting hypoxia-inducible factor | journal = J. Biol. Chem. | volume = 279 | issue = 14 | pages = 14391–7 | year = 2004 | pmid = 14734545 | doi = 10.1074/jbc.M313614200 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Kato H, Tamamizu-Kato S, Shibasaki F | title = Histone deacetylase 7 associates with hypoxia-inducible factor 1alpha and increases transcriptional activity | journal = J. Biol. Chem. | volume = 279 | issue = 40 | pages = 41966–74 | year = 2004 | pmid = 15280364 | doi = 10.1074/jbc.M406320200 }}
*{{cite journal  | author=Lee C, Kim SJ, Jeong DG, ''et al.'' |title=Structure of human FIH-1 reveals a unique active site pocket and interaction sites for HIF-1 and von Hippel-Lindau. |journal=J. Biol. Chem. |volume=278 |issue= 9 |pages= 7558-63 |year= 2003 |pmid= 12482756 |doi= 10.1074/jbc.M210385200 }}
* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | year = 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
*{{cite journal | author=Koivunen P, Hirsilä M, Günzler V, ''et al.'' |title=Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases. |journal=J. Biol. Chem. |volume=279 |issue= 11 |pages= 9899-904 |year= 2004 |pmid= 14701857 |doi= 10.1074/jbc.M312254200 }}
* {{cite journal | vauthors = Cockman ME, Lancaster DE, Stolze IP, Hewitson KS, McDonough MA, Coleman ML, Coles CH, Yu X, Hay RT, Ley SC, Pugh CW, Oldham NJ, Masson N, Schofield CJ, Ratcliffe PJ | title = Posttranslational hydroxylation of ankyrin repeats in IκB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH) | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 103 | issue = 40 | pages = 14767–72 | year = 2006 | pmid = 17003112 | pmc = 1578504 | doi = 10.1073/pnas.0606877103 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
* {{cite journal | vauthors = Coleman ML, McDonough MA, Hewitson KS, Coles C, Mecinovic J, Edelmann M, Cook KM, Cockman ME, Lancaster DE, Kessler BM, Oldham NJ, Ratcliffe PJ, Schofield CJ | title = Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor | journal = J. Biol. Chem. | volume = 282 | issue = 33 | pages = 24027–38 | year = 2007 | pmid = 17573339 | doi = 10.1074/jbc.M704102200 }}
*{{cite journal  | author=Linke S, Stojkoski C, Kewley RJ, ''et al.'' |title=Substrate requirements of the oxygen-sensing asparaginyl hydroxylase factor-inhibiting hypoxia-inducible factor. |journal=J. Biol. Chem. |volume=279 |issue= 14 |pages= 14391-7 |year= 2004 |pmid= 14734545 |doi= 10.1074/jbc.M313614200 }}
*{{cite journal | author=Kato H, Tamamizu-Kato S, Shibasaki F |title=Histone deacetylase 7 associates with hypoxia-inducible factor 1alpha and increases transcriptional activity. |journal=J. Biol. Chem. |volume=279 |issue= 40 |pages= 41966-74 |year= 2004 |pmid= 15280364 |doi= 10.1074/jbc.M406320200 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Cockman ME, Lancaster DE, Stolze IP, ''et al.'' |title=Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH). |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 40 |pages= 14767-72 |year= 2006 |pmid= 17003112 |doi= 10.1073/pnas.0606877103 }}
*{{cite journal | author=Fukuba H, Yamashita H, Nagano Y, ''et al.'' |title=Siah-1 facilitates ubiquitination and degradation of factor inhibiting HIF-1alpha (FIH). |journal=Biochem. Biophys. Res. Commun. |volume=353 |issue= 2 |pages= 324-9 |year= 2007 |pmid= 17188242 |doi= 10.1016/j.bbrc.2006.12.051 }}
*{{cite journal  | author=Coleman ML, McDonough MA, Hewitson KS, ''et al.'' |title=Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor. |journal=J. Biol. Chem. |volume=282 |issue= 33 |pages= 24027-38 |year= 2007 |pmid= 17573339 |doi= 10.1074/jbc.M704102200 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{PDB Gallery|geneid=55662}}
{{WikiDoc Sources}}
 
 
{{Gene-10-stub}}

Latest revision as of 13:36, 31 August 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Hypoxia-inducible factor 1-alpha inhibitor is a protein that in humans is encoded by the HIF1AN gene.[1][2]

Interactions

HIF1AN has been shown to interact with HIF1A[1] and Von Hippel-Lindau tumor suppressor.[1]

References

  1. ↑ 1.0 1.1 1.2 Mahon PC, Hirota K, Semenza GL (Oct 2001). "FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity". Genes Dev. 15 (20): 2675–86. doi:10.1101/gad.924501. PMC 312814. PMID 11641274.
  2. ↑ "Entrez Gene: HIF1AN hypoxia-inducible factor 1, alpha subunit inhibitor".

Further reading


Retrieved from "https://www.wikidoc.org/index.php?title=HIF1AN&oldid=1414344"