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Latest revision as of 20:13, 24 February 2014

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Synonyms and keywords: Thymoma with immunodeficiency

Overview

Good syndrome is a rare, adult-onset primary immunodeficiency suspected in patients who exhibit hypogammaglobulinemia and low levels of B cells along with a benign thymic tumor (thymoma) on chest X-ray. Symptoms include frequent opportunistic infections involving the sinuses and lungs, including severe CMV disease, P. carinii pneumonia, and mucocutaneous candidiasis. While the cause of Good syndrome remains unknown, there is some evidence that a defect of the bone marrow is involved. Treatment includes removal of the thymic tumor and immunoglobulin replacement.[1][2]

References

  1. Kelleher, P.; Misbah, SA. (2003). "What is Good's syndrome? Immunological abnormalities in patients with thymoma". J Clin Pathol. 56 (1): 12–6. PMID 12499426. Unknown parameter |month= ignored (help)
  2. Tarr, PE.; Sneller, MC.; Mechanic, LJ.; Economides, A.; Eger, CM.; Strober, W.; Cunningham-Rundles, C.; Lucey, DR. (2001). "Infections in patients with immunodeficiency with thymoma (Good syndrome). Report of 5 cases and review of the literature". Medicine (Baltimore). 80 (2): 123–33. PMID 11307588. Unknown parameter |month= ignored (help)