Glucagonoma laboratory tests: Difference between revisions
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==Overview== | ==Overview== | ||
Laboratory findings consistent with the diagnosis of glucagonoma include a serum [[glucagon]] concentration of 1000 pg/ml or greater. | Laboratory findings consistent with the diagnosis of glucagonoma include a serum [[glucagon]] concentration of 1000 pg/ml or greater. | ||
==Laboratory Findings== | ==Laboratory Findings== | ||
The laboratory findings associated with glucagonoma are:<ref name="pmid15313692">{{cite journal| author=Zhang M, Xu X, Shen Y, Hu ZH, Wu LM, Zheng SS| title=Clinical experience in diagnosis and treatment of glucagonoma syndrome. | journal=Hepatobiliary Pancreat Dis Int | year= 2004 | volume= 3 | issue= 3 | pages= 473-5 | pmid=15313692 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15313692 }} </ref><ref name="lab">Glucagonoma. Wikipedia. https://en.wikipedia.org/wiki/Glucagonoma. Accessed on October 15,2015</ref><ref name="pmid15313692" /><ref name="pmid8606627" /><ref name="pmid17873310">{{cite journal| author=Kindmark H, Sundin A, Granberg D, Dunder K, Skogseid B, Janson ET et al.| title=Endocrine [[pancreatic tumors]] with [[glucagon]] hypersecretion: a retrospective study of 23 cases during 20 years. | journal=Med Oncol | year= 2007 | volume= 24 | issue= 3 | pages= 330-7 | pmid=17873310 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17873310 }}</ref> | |||
'''Serum glucagon''' | |||
*Increased plasma [[glucagon]] levels >500 pg/mL (Normal [[Glucagon|glucagon level]] is less than 50 pg/mL). | |||
*Concentrations above 1000 pg/mL are diagnostic of glucagonoma. | |||
*Some conditions can increase [[glucagon]] level to a level less than 500 pg/mL such as fasting and [[hypoglycemia]]. | |||
*Some symptomatic glucagonomas are associated with normal glucagon serum level. So, a serum glucagon concentration below 500 pg/mL does not exclude a glucagonoma.<ref name="pmid17873310" /> | *Some symptomatic glucagonomas are associated with normal glucagon serum level. So, a serum glucagon concentration below 500 pg/mL does not exclude a glucagonoma.<ref name="pmid17873310" /> | ||
'''Other laboratory findings''' | |||
* Blood tests may also reveal low concentrations of [[amino acids]], [[zinc]], and [[essential fatty acid]]s. | * Blood tests may also reveal low concentrations of [[amino acids]], [[zinc]], and [[essential fatty acid]]s. | ||
* A [[complete blood count|CBC]] to diagnose [[anemia]] | * A [[complete blood count|complete blood count]] ([[complete blood count|CBC]]) to diagnose [[anemia]]. | ||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
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Latest revision as of 01:48, 27 November 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Parminder Dhingra, M.D. [2], Mohammed Abdelwahed M.D[3]
Overview
Laboratory findings consistent with the diagnosis of glucagonoma include a serum glucagon concentration of 1000 pg/ml or greater.
Laboratory Findings
The laboratory findings associated with glucagonoma are:[1][2][1][3][4]
Serum glucagon
- Increased plasma glucagon levels >500 pg/mL (Normal glucagon level is less than 50 pg/mL).
- Concentrations above 1000 pg/mL are diagnostic of glucagonoma.
- Some conditions can increase glucagon level to a level less than 500 pg/mL such as fasting and hypoglycemia.
- Some symptomatic glucagonomas are associated with normal glucagon serum level. So, a serum glucagon concentration below 500 pg/mL does not exclude a glucagonoma.[4]
Other laboratory findings
- Blood tests may also reveal low concentrations of amino acids, zinc, and essential fatty acids.
- A complete blood count (CBC) to diagnose anemia.
References
- ↑ 1.0 1.1 Zhang M, Xu X, Shen Y, Hu ZH, Wu LM, Zheng SS (2004). "Clinical experience in diagnosis and treatment of glucagonoma syndrome". Hepatobiliary Pancreat Dis Int. 3 (3): 473–5. PMID 15313692.
- ↑ Glucagonoma. Wikipedia. https://en.wikipedia.org/wiki/Glucagonoma. Accessed on October 15,2015
- ↑
- ↑ 4.0 4.1 Kindmark H, Sundin A, Granberg D, Dunder K, Skogseid B, Janson ET; et al. (2007). "Endocrine [[pancreatic tumors]] with [[glucagon]] hypersecretion: a retrospective study of 23 cases during 20 years". Med Oncol. 24 (3): 330–7. PMID 17873310. URL–wikilink conflict (help)