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{{Gliomatosis cerebri}}
'''For patient information click [[{{PAGENAME}} (patient information)|here]]'''.
'''For patient information click [[{{PAGENAME}} (patient information)|here]]'''.


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  ICD10          =  |
  ICD9          = |
  ICDO          = 9381/3 |
  OMIM          = |
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  MeshID        = D018302 |
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==Overview==
{{SK}} Infiltrative diffuse astrocytosis; astrocytosis cerebri; glioblastosis cerebri; GC; diffuse gliomatosis; glioblastosis; central diffuse schwannosis; diffuse glioma of the brain; diffuse glioma of brain; gliomatous hypertrophy; blastomatous type of diffuse sclerosis; gliomatosis diffusa; glioblastoma multiforme; astrocytoma; brain tumor
'''Gliomatosis cerebri (infiltrative diffuse astrocytosis)''' is a rare primary [[brain tumor]]. It is commonly characterized by diffuse infiltration of the brain with neoplastic [[glial cells]] that affect various areas of the cerebral lobes<ref>http://rad.usuhs.mil/medpix/radpix.html?mode=single&comebackto=mode%3Dgeo_browse&recnum=923</ref>.


While gliomatosis cerebri can occur at any age, it is generally found in the third and fourth decades of life. It may affect any part of the [[brain]] or even the [[spinal cord]], [[optic nerve]] and compact [[white matter]]. Clinical manifestations are indefinite, and include [[headache]], [[seizures]], visual disturbances, [[corticospinal tract]] deficits, [[lethargy]], and [[dementia]].
==[[Gliomatosis cerebri overview|Overview]]==


Before the advent of [[MRI]], diagnosis was generally not established until [[autopsy]]. Even with MRI, however, diagnosis is difficult.<ref>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10696026&dopt=Abstract</ref> Typically, gliomatosis cerebri appears as a diffuse, poorly circumscribed, infiltrating non-enhancing lesion that is hyperintense on T2-weighted images and expands the cerebral white matter. It is difficult to distinguish from highly infiltrate anaplastic astrocytoma or [[Glioblastoma multiforme|GBM]].<ref>http://www.urmc.rochester.edu/smd/Rad/neurocases/Neurocase01.htm</ref> The prognosis for gliomatosis cerebri is generally poor, with a median survival time of only 12 months.<ref>http://www.childrenshospital.org/az/Site963/mainpageS963P0.html</ref> Surgery is not practical considering the extent of the disease, standard [[chemotherapy]] (nitrosourea) has been unsuccessful, and while brain irradiation can stabilize or improve neurologic function in some patients, its impact on survival has yet to be proven.{{Fact|date=February 2007}}
==[[Gliomatosis cerebri historical perspective|Historical Perspective]]==
 
==[[Gliomatosis cerebri classification|Classification]]==
 
==[[Gliomatosis cerebri pathophysiology|Pathophysiology]]==
 
==[[Gliomatosis cerebri causes|Causes]]==
 
==[[Gliomatosis cerebri differential diagnosis|Differentiating Gliomatosis cerebri from other Diseases]]==
 
==[[Gliomatosis cerebri epidemiology and demographics|Epidemiology and Demographics]]==
 
==[[Gliomatosis cerebri risk factors|Risk Factors]]==
 
==[[Gliomatosis cerebri screening|Screening]]==
 
==[[Gliomatosis cerebri natural history, complications, and prognosis|Natural History, Complications, and Prognosis]]==
 
==Diagnosis==
[[Gliomatosis cerebri staging|Staging]] | [[Gliomatosis cerebri history and symptoms|History and Symptoms]] | [[Gliomatosis cerebri physical examination|Physical Examination]] | [[Gliomatosis cerebri laboratory tests|Laboratory Findings]] | [[Gliomatosis cerebri chest x ray|Chest X Ray]] | [[Gliomatosis cerebri CT|CT]] | [[Gliomatosis cerebri MRI|MRI]] | [[Gliomatosis cerebri ultrasound|Ultrasound]] | [[Gliomatosis cerebri other imaging findings|Other Imaging Findings]] | [[Gliomatosis cerebri other diagnostic studies|Other Diagnostic Studies]]
 
==Treatment==
[[Gliomatosis cerebri medical therapy|Medical Therapy]] | [[Gliomatosis cerebri surgery|Surgery]] | [[Gliomatosis cerebri primary prevention|Primary Prevention]] | [[Gliomatosis cerebri secondary prevention|Secondary Prevention]] | [[Gliomatosis cerebri cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] | [[Gliomatosis cerebri future or investigational therapies|Future or Investigational Therapies]]
 
==Case Studies==
[[Gliomatosis cerebri case study one|Case#1]]


==References==
==References==
{{reflist|2}}
{{reflist|2}}


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[[de:Gliomatosis cerebri]]
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Latest revision as of 01:45, 27 November 2017

Gliomatosis cerebri Microchapters

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]

Synonyms and keywords: Infiltrative diffuse astrocytosis; astrocytosis cerebri; glioblastosis cerebri; GC; diffuse gliomatosis; glioblastosis; central diffuse schwannosis; diffuse glioma of the brain; diffuse glioma of brain; gliomatous hypertrophy; blastomatous type of diffuse sclerosis; gliomatosis diffusa; glioblastoma multiforme; astrocytoma; brain tumor

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Gliomatosis cerebri from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications, and Prognosis

Diagnosis

Staging | History and Symptoms | Physical Examination | Laboratory Findings | Chest X Ray | CT | MRI | Ultrasound | Other Imaging Findings | Other Diagnostic Studies

Treatment

Medical Therapy | Surgery | Primary Prevention | Secondary Prevention | Cost-Effectiveness of Therapy | Future or Investigational Therapies

Case Studies

Case#1

References

Template:Nervous tissue tumors


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