Glioma natural history, complications and prognosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]

Overview

Common complications of glioma include brain herniation, hydrocephalus, coma, metastasis, and recurrence. The prognosis of glioma varies with the grade of tumor. The 1-year and 2-year survival rate of patients with malignant glioma is approximately 50% and 25%, respectively.[1]

Complications

Common complications of glioma include:

Prognosis

  • The prognosis of glioma varies with the grade of tumor: WHO grade 1 and WHO grade 4 have the most favorable and worst prognosis, respectively.
  • The 1-year and 2-year survival rate of patients with malignant glioma is approximately 50% and 25%, respectively.
  • Post-operative radiation therapy is often used as an adjunct to surgery in the treatment of high-grade gliomas as it has shown to double the median survival for high-grade gliomas to 37 weeks (versus 17 weeks with surgery alone).
  • The prognosis of glioma may depend on other factors which include:[1]
  • Location of the tumor (brain or spinal cord)
  • Resectability
  • Primary diagnosis vs. recurrence
  • Specific mutations:

References

  1. 1.0 1.1 Prognostic factors of glioma. National Cancer Institute. http://www.cancer.gov/types/brain/patient/adult-brain-treatment-pdq