Glioblastoma multiforme classification
|
Glioblastoma multiforme Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Glioblastoma multiforme classification On the Web |
|
American Roentgen Ray Society Images of Glioblastoma multiforme classification |
|
Risk calculators and risk factors for Glioblastoma multiforme classification |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]
Overview
Glioblastoma may be classified into several subtypes based on its origin and molecular alterations.[1][2]
Classification
Glioblastoma may be classified according to its origin into two subtypes: Primary and secondary.[1]
| Differential diagnosis | Characteristic features of the differential diagnosis |
|---|---|
| |
| |
| |
| |
| |
| |
| |
| |
|
Primary glioblastoma
- De novo origin
- More aggressive
- Occurs in older patients
Secondary glioblastoma
- Arises from pre-existing lower grade gliomas
- Less aggressive
- Occurs in younger patients
Glioblastoma may be classified according to its molecular alterations into four subtypes:[2]
- Classic
- Proneural
- Mesenchymal
- Neural
References
- ↑ 1.0 1.1 Classification of glioblastoma multiforme. Dr Dylan Kurda and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/glioblastoma
- ↑ 2.0 2.1 Verhaak RG, Hoadley KA, Purdom E, Wang V, Qi Y, Wilkerson MD; et al. (2010). "Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1". Cancer Cell. 17 (1): 98–110. doi:10.1016/j.ccr.2009.12.020. PMC 2818769. PMID 20129251.