Glioblastoma multiforme classification: Difference between revisions

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! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF|Differential diagnosis}}
! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF|Subtype of glioblastoma}}
! style="background: #4479BA; width: 400px;" | {{fontcolor|#FFF|Characteristic features of the differential diagnosis}}
! style="background: #4479BA; width: 400px;" | {{fontcolor|#FFF|Characteristic features}}
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:[[Metastasis|Cerebral metastasis]]
:Primary glioblastoma
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*May look identical
*De novo origin
*Both may appear multifocal
*More aggressive
*Metastases are centred on grey-white matter junction and spare the overlying cortex
*Occurs in older patients
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:[[Primary CNS lymphoma]]
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*In patients with [[AIDS]]
*Central [[necrosis]] is more common
*Homogeneously enhancing on [[MRI]]
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:[[Cerebral abscess]]
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*Central restricted diffusion is helpful
*[[Hemorrhagic]] then assessment may be difficult
*Presence of smooth and complete SWI low intensity rim
*Presence of dual rim sign
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:[[Astrocytoma|Anaplastic astrocytoma]]
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*No central [[necrosis]]
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:[[Demyelination|Tumefactive demyelination]]
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*Can appear similar
*Open ring pattern of enhancement
*Younger patients
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:[[Stroke]]
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*History is suggestive of diagnosis
*No elevated choline
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:[[Toxoplasmosis|Cerebral toxoplasmosis]]
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*In patients with [[AIDS]]
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:[[Radiation|Radiation necrosis]]
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*History of [[radiation]] exposure
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:[[Encephalitis]]
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*History of [[fever]]
*[[Confusion]]
*[[Stiff neck]] may be present suggestive of [[meningoencephalitis]]
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:[[Oligodendroglioma]]
:Secondary glioblastoma
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*[[Biopsy]] helps in differentiation
*Slower growing [[tumor]]
*Better [[prognosis]]
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:[[Epilepsy]]
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*Multifactorial
*Mass may or may not be observed on MRI depending on the cause
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====Primary glioblastoma====
*De novo origin
*More aggressive
*Occurs in older patients
====Secondary glioblastoma====
*Arises from pre-existing lower grade gliomas
*Arises from pre-existing lower grade gliomas
*Less aggressive
*Less aggressive
*Occurs in younger patients
*Occurs in younger patients
|}


Glioblastoma may be classified according to its molecular alterations into four subtypes:<ref name="pmid20129251">{{cite journal| author=Verhaak RG, Hoadley KA, Purdom E, Wang V, Qi Y, Wilkerson MD et al.| title=Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. | journal=Cancer Cell | year= 2010 | volume= 17 | issue= 1 | pages= 98-110 | pmid=20129251 | doi=10.1016/j.ccr.2009.12.020 | pmc=PMC2818769 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20129251  }} </ref>
Glioblastoma may be classified according to its molecular alterations into four subtypes:<ref name="pmid20129251">{{cite journal| author=Verhaak RG, Hoadley KA, Purdom E, Wang V, Qi Y, Wilkerson MD et al.| title=Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. | journal=Cancer Cell | year= 2010 | volume= 17 | issue= 1 | pages= 98-110 | pmid=20129251 | doi=10.1016/j.ccr.2009.12.020 | pmc=PMC2818769 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20129251  }} </ref>

Revision as of 16:17, 16 September 2015

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]

Overview

Glioblastoma may be classified into several subtypes based on its origin and molecular alterations.[1][2]

Classification

Glioblastoma may be classified according to its origin into two subtypes: Primary and secondary.[1]

Subtype of glioblastoma Characteristic features
Primary glioblastoma
  • De novo origin
  • More aggressive
  • Occurs in older patients
Secondary glioblastoma
  • Arises from pre-existing lower grade gliomas
  • Less aggressive
  • Occurs in younger patients


Glioblastoma may be classified according to its molecular alterations into four subtypes:[2]

  • Classic
  • Proneural
  • Mesenchymal
  • Neural

References

  1. ↑ 1.0 1.1 Classification of glioblastoma multiforme. Dr Dylan Kurda and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/glioblastoma
  2. ↑ 2.0 2.1 Verhaak RG, Hoadley KA, Purdom E, Wang V, Qi Y, Wilkerson MD; et al. (2010). "Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1". Cancer Cell. 17 (1): 98–110. doi:10.1016/j.ccr.2009.12.020. PMC 2818769. PMID 20129251.


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