Gestational trophoblastic neoplasia epidemiology and demographics

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Monalisa Dmello, M.B,B.S., M.D. [2]

Overveiw

The reported incidence of choriocarcinoma in the United States is 2 to 7 per 100,000 pregnancies. The U.S. age-standardized (1960 World Population Standard) incidence rate of choriocarcinoma is approximately 0.18/100,000 women between the ages of 15 - 49 years.

Epidemiology and Demographics

Incidence

  • The reported incidence of choriocarcinoma in the United States is 2 to 7 per 100,000 pregnancies.[1]
  • The U.S. age-standardized (1960 World Population Standard) incidence rate of choriocarcinoma is approximately 0.18/100,000 women between the ages of 15 - 49 years.[2]
  • The incidence in Europe ranges from 2 - 3 per 100, 000.[3][4][5]

Prevalence

  • The prevalance of choriocarcinoma in the United States is 0.075 - 0.01 per 100, 000.[6][7]
  • The prevalence rates from Southeast Asia are 1.5 - 2.5 times higher.[8][9]

References

  1. General Information About Gestational Trophoblastic Disease National Cancer Institute. http://www.cancer.gov/types/gestational-trophoblastic/hp/gtd-treatment-pdq/#section/_1. Accessed on October7, 2015
  2. Altieri A, Franceschi S, Ferlay J, Smith J, La Vecchia C (November 2003). "Epidemiology and aetiology of gestational trophoblastic diseases". Lancet Oncol. 4 (11): 670–8. PMID 14602247.
  3. Olsen, Jørgen H.; Mellemkjaer, Lene; Gridley, Gloria; Brinton, Louise; Johansen, Christoffer; Kjaer, Susanne Krüger (1999). "Molar pregnancy and risk for cancer in women and their male partners". American Journal of Obstetrics and Gynecology. 181 (3): 630–634. doi:10.1016/S0002-9378(99)70504-1. ISSN 0002-9378.
  4. Flam F, Lundström-Lindstedt V, Rutqvist LE (March 1992). "Incidence of gestational trophoblastic disease in Stockholm County, 1975-1988". Eur. J. Epidemiol. 8 (2): 173–7. PMID 1322822.
  5. Ringertz N (1970). "Hydatidiform mole, invasive mole and choriocarcinoma in Sweden 1958-1965". Acta Obstet Gynecol Scand. 49 (2): 195–203. PMID 5519491.
  6. Buckley JD (March 1984). "The epidemiology of molar pregnancy and choriocarcinoma". Clin Obstet Gynecol. 27 (1): 153–9. PMID 6705308.
  7. Burton JL, Lidbury EA, Gillespie AM, Tidy JA, Smith O, Lawry J, Hancock BW, Wells M (May 2001). "Over-diagnosis of hydatidiform mole in early tubal ectopic pregnancy". Histopathology. 38 (5): 409–17. PMID 11422477.
  8. Cortes R. Enfenpraded trophoblastic gestational. In obstetrician Clinica. Second edition. Edited by IZigheelboim, D Guariglia. Caracas, Editorial Disinlimed. 2005:374–379.
  9. Kite NH, Lipscomb GH, Merrill K. Molar corneal ectopic pregnancy. Obstet Gynecol. 2002;99:689–692.

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