Gentian violet: Difference between revisions

Gentian violet
	Adult Indications & Dosage
	Pediatric Indications & Dosage
	Contraindications
	Warnings & Precautions
	Adverse Reactions
	Drug Interactions
	Use in Specific Populations
	Administration & Monitoring
	Overdosage
	Pharmacology
	Clinical Studies
	How Supplied
	Images
	Patient Counseling Information
	Precautions with Alcohol
	Brand Names
	Look-Alike Names

VisualWikitext

Latest revision as of 15:51, 21 April 2015

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Kiran Singh, M.D. [2]

Disclaimer

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NOTE: Most over the counter (OTC) are not reviewed and approved by the FDA. However, they may be marketed if they comply with applicable regulations and policies. FDA has not evaluated whether this product complies.

Overview

Gentian violet is an antifungal agent that is FDA approved for the treatment of candidal vulvovaginitis and as an antiseptic to protect against skin infection in minor cuts, scrapes or burns. Common adverse reactions include discoloration of skin.

Adult Indications and Dosage

FDA-Labeled Indications and Dosage (Adult)

Indications

First aid antiseptic to help protect against skin infection in minor cuts, scrapes or burns.

Off-Label Use and Dosage (Adult)

Guideline-Supported Use

There is limited information regarding Off-Label Guideline-Supported Use of Gentian violet in adult patients.

Non–Guideline-Supported Use

There is limited information regarding Off-Label Non–Guideline-Supported Use of Gentian violet in adult patients.

Pediatric Indications and Dosage

FDA-Labeled Indications and Dosage (Pediatric)

Indications

First aid antiseptic to help protect against skin infection in minor cuts, scrapes or burns

Off-Label Use and Dosage (Pediatric)

Guideline-Supported Use

There is limited information regarding Off-Label Guideline-Supported Use of Gentian violet in pediatric patients.

Non–Guideline-Supported Use

There is limited information regarding Off-Label Non–Guideline-Supported Use of Gentian violet in pediatric patients.

Contraindications

There is limited information regarding Gentian violet Contraindications in the drug label.

Warnings

For external use only

DO NOT USE

In eyes; with bandages; on large areas of the body; longer than one week unless directed by a doctor; stop use and consult a doctor if condition persists; in case of deep puncture wounds, animal bites or serious burns, consult a doctor; if known to be sensitive to any ingredients in the product; do not apply to ulcerative lesions as this may result in tattooing of the skin.

STOP USE AND ASK A DOCTOR OR PHARMACIST

If skin irritation or sensitivity develops or increases or if the condition persists or gets worse.

Adverse Reactions

Clinical Trials Experience

There is limited information regarding Clinical Trial Experience of Gentian violet in the drug label.

Postmarketing Experience

There is limited information regarding Postmarketing Experience of Gentian violet in the drug label.

Drug Interactions

There is limited information regarding Drug interactions of Gentian violet in the drug label.

Use in Specific Populations

Pregnancy

Pregnancy Category (FDA): There is no FDA guidance on usage of Gentian violet in women who are pregnant.
Pregnancy Category (AUS):

There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Gentian violet in women who are pregnant.

Labor and Delivery

There is no FDA guidance on use of Gentian violet during labor and delivery.

Nursing Mothers

There is no FDA guidance on the use of Gentian violet with respect to nursing mothers.

Pediatric Use

There is no FDA guidance on the use of Gentian violet with respect to pediatric patients.

Geriatic Use

There is no FDA guidance on the use of Gentian violet with respect to geriatric patients.

Gender

There is no FDA guidance on the use of Gentian violet with respect to specific gender populations.

Race

There is no FDA guidance on the use of Gentian violet with respect to specific racial populations.

Renal Impairment

There is no FDA guidance on the use of Gentian violet in patients with renal impairment.

Hepatic Impairment

There is no FDA guidance on the use of Gentian violet in patients with hepatic impairment.

Females of Reproductive Potential and Males

There is no FDA guidance on the use of Gentian violet in women of reproductive potentials and males.

Immunocompromised Patients

There is no FDA guidance one the use of Gentian violet in patients who are immunocompromised.

Administration and Monitoring

Administration

Topical
Clean the affected area. Apply a small amount using a cotton-tipped applicator one to three times daily. Do not bandage.

Monitoring

There is limited information regarding Monitoring of Gentian violet in the drug label.

IV Compatibility

There is limited information regarding IV Compatibility of Gentian violet in the drug label.

Overdosage

There is limited information regarding Chronic Overdose of Gentian violet in the drug label.

Pharmacology

This image is provided by the National Library of Medicine.

Mechanism of Action

There is limited information regarding Mechanism of action of Gentian violet in the drug label.

Structure

There is limited information regarding Gentian violet Structure in the drug label.

Pharmacodynamics

There is limited information regarding Pharmacodynamics of Gentian violet in the drug label.

Pharmacokinetics

There is limited information regarding Pharmacokinetics of Gentian violet in the drug label.

Nonclinical Toxicology

There is limited information regarding Nonclinical Toxicology of Gentian violet in the drug label.

Clinical Studies

There is limited information regarding Clinical Studies of Gentian violet in the drug label.

How Supplied

There is limited information regarding Gentian violet How Supplied in the drug label.

Storage

Store at controlled room temperature. Will stain skin and clothing.

Images

Drug Images

{{#ask: Page Name::Gentian violet |?Pill Name |?Drug Name |?Pill Ingred |?Pill Imprint |?Pill Dosage |?Pill Color |?Pill Shape |?Pill Size (mm) |?Pill Scoring |?NDC |?Drug Author |format=template |template=DrugPageImages |mainlabel=- |sort=Pill Name }}

Package and Label Display Panel

{{#ask: Label Page::Gentian violet |?Label Name |format=template |template=DrugLabelImages |mainlabel=- |sort=Label Page }}

Patient Counseling Information

KEEP OUT OF REACH OF CHILDREN.

In case of accidental ingestion, seek medical help or contact a Poison Control Center immediately.

Precautions with Alcohol

Alcohol-Gentian violet interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.

Brand Names

GENTIAN VIOLET®^[1]

Look-Alike Drug Names

A® — B®^[2]

Drug Shortage Status

Price

References

The contents of this FDA label are provided by the National Library of Medicine.

↑ "gentian violet solution".
↑ "http://www.ismp.org". External link in |title= (help)

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[1] "gentian violet solution".

[www.ismp.org-2] "http://www.ismp.org". External link in |title= (help)

[1]

[2]

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+|drugClass=[[antifungal]] agent
-|  CASNo=548-62-9
+|indicationType=treatment
-|  PubChem=11057
+|indication=candidal [[vulvovaginitis]] and as an antiseptic to protect against skin infection in minor cuts, scrapes or burns
-|  SMILES=
+|adverseReactions=discoloration of skin
-|  MeSHName=Gentian+violet
+|blackBoxWarningTitle=<span style="color:#FF0000;">ConditionName: </span>
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-|  MolarMass=407.979
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+<!--FDA-Labeled Indications and Dosage (Pediatric)-->
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+|fdaLIADPed===Indications==
-'''Gentian violet''' ([[crystal violet]], '''Methyl Violet 10B''', hexamethyl [[pararosaniline]] chloride) is an [[antifungal drug|antifungal agent]],
+* First aid antiseptic to help protect against skin infection in minor cuts, scrapes or burns
-the primary agent used in the [[Gram staining|Gram stain test]], perhaps the single most important bacterial identification test in use today, and it is also used by hospitals for the treatment of serious heat burns and other injuries to the skin and gums.  Typically prepared as a weak (e.g. 1%) solution in water, it is painted on skin or gums to treat or prevent [[mycosis|fungal infections]]. Gentian violet does not require a doctor's prescription (in the US), but is not easily found in drug stores. [[Tampon]]s treated with gentian violet are sometimes used for vaginal applications.
+|offLabelPedGuideSupport=* There is limited information regarding <i>Off-Label Guideline-Supported Use</i> of {{PAGENAME}} in pediatric patients.
+|offLabelPedNoGuideSupport=* There is limited information regarding <i>Off-Label Non–Guideline-Supported Use</i> of {{PAGENAME}} in pediatric patients.
+|warnings=* For external use only
+'''DO NOT USE'''
+* In eyes; with bandages; on large areas of the body; longer than one week unless directed by a doctor; stop use and consult a doctor if condition persists; in case of deep puncture wounds, animal bites or serious burns, consult a doctor; if known to be sensitive to any ingredients in the product; do not apply to ulcerative lesions as this may result in tattooing of the skin.
+'''STOP USE AND ASK A DOCTOR OR PHARMACIST'''
+* If skin irritation or sensitivity develops or increases or if the condition persists or gets worse.
+|clinicalTrials=There is limited information regarding <i>Clinical Trial Experience</i> of {{PAGENAME}} in the drug label.
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+|useInImmunocomp=* There is no FDA guidance one the use of {{PAGENAME}} in patients who are immunocompromised.
+|administration=* Topical
+* Clean the affected area. Apply a small amount using a cotton-tipped applicator one to three times daily. Do not bandage.
+|monitoring=* There is limited information regarding <i>Monitoring</i> of {{PAGENAME}} in the drug label.
+<!--IV Compatibility-->
+|IVCompat=* There is limited information regarding <i>IV Compatibility</i> of {{PAGENAME}} in the drug label.
+|overdose=* There is limited information regarding <i>Chronic Overdose</i> of {{PAGENAME}} in the drug label.
-Gentian violet is also known as Andergon, Aniline violet, Axuris, Badil, Basic Violet 3, Brilliant Violet 58, Gentiaverm, Hexamethyl-p-rosaniline chloride, Meroxylan, Meroxyl, Methylrosalinide chloride, Methyl Violet 10BNS, Pyoktanin, Vianin, Viocid, and Viola Crystallina.
-==Applications==
-Commonly used for
-: [[Ringworm|Tinea]]; e.g. [[Athlete's foot]], [[jock itch]], and ringworm
-: [[Candidiasis|Candida albicans]] and related infections; e.g. [[Candidiasis|thrush]], yeast infections
-: [[Mouth ulcer]]s<sup>[http://www.emro.who.int/cah/pdf/IMCI-Chartbook-Sud-Eng.pdf]</sup>
-In [[forensics]], gentian violet was used to develop [[fingerprint]]s.
+<!--Drug box 2-->
+|drugBox=[[File:Gentian violet wikipedia.png|thumb|none|600px|This image is provided by the National Library of Medicine.]]
-In [[body piercing]], gentian violet is commonly used to mark the location for placing a tongue piercing.
+|mechAction=* There is limited information regarding <i>Mechanism of action</i> of {{PAGENAME}} in the drug label.
+|PD=* There is limited information regarding <i>Pharmacodynamics</i> of {{PAGENAME}} in the drug label.
+|PK=* There is limited information regarding <i>Pharmacokinetics</i> of {{PAGENAME}} in the drug label.
+|nonClinToxic=* There is limited information regarding <i>Nonclinical Toxicology</i> of {{PAGENAME}} in the drug label.
+|clinicalStudies=* There is limited information regarding <i>Clinical Studies</i> of {{PAGENAME}} in the drug label.
+|storage=* Store at controlled room temperature. Will stain skin and clothing.
+|packLabel=[[File:Gentian violet.jpg|thumb|none|600px|This image is provided by the National Library of Medicine.]]
-Engineering students in Canada traditionally use this substance to dye their whole bodies purple in preparation for homecoming celebrations and [[frosh week]]. Additionally, Queens University's golden leather engineering jacket, also known as Golden Party Armour or GPA, is purpled using this dye.
+[[File:Gentian violet ingredients and appearance.png|thumb|none|600px|This image is provided by the National Library of Medicine.]]
+|fdaPatientInfo='''KEEP OUT OF REACH OF CHILDREN'''.
+* In case of accidental ingestion, seek medical help or contact a Poison Control Center immediately.
+|alcohol=* Alcohol-{{PAGENAME}} interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.
+|brandNames=* GENTIAN VIOLET®<ref>{{Cite web | title =gentian violet solution| url =http://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a972c857-1e3e-4a89-9fb2-da5a64d55bf7 }}</ref>
-==Precautions==
-The Food and Drug Administration has determined that gentian violet has not been shown by adequate scientific data to be safe for use in animal feed. Use of gentian violet in animal feed causes the feed to be adulterated and in violation of the Federal Food, Drug, and Cosmetic Act. 21CFR589.1000
-Gentian violet's worst common side effect is staining skin and cloth, but if used on [[ulceration]]s or open [[wound]]s it can cause [[tattoo|tattooing]]. It is generally considered safe for use on children and [[breastfeeding]] mothers. It has even been applied to the mouth and lips of premature infants, and has a long history of safe use. Many have recommended it for thrush on the nipple, and [[La Leche League]] lists gentian violet as a possible alternative.<ref>[http://www.lalecheleague.org/FAQ/thrush.html www.lalecheleague.org]</ref>  However, in large quantities, gentian violet may lead to ulceration of a baby's mouth and throat and is linked with mouth cancer.  [[William Sears (physician)|Dr. Sears]] recommends using it sparingly.<ref>[http://www.askdrsears.com/html/8/T083100.asp www.askdrsears.com]</ref> Gentian violet has also been linked to cancer in the digestive tract of other animals.<ref>[http://extoxnet.orst.edu/newsletters/n115_91.htm extoxnet.orst.edu]</ref>
+|lookAlike=* A® — B®<ref name="www.ismp.org">{{Cite web  | last =  | first =  | title = http://www.ismp.org | url = http://www.ismp.org | publisher =  | date =  }}</ref>
-When using gentian in order to purple skin or jackets, care should be taken to mix only low concentrations of the [[crystal]] into warm water. This avoids the material attaining a golden hue. Additionally, jackets with a waterproof coating should be scrubbed lightly with a scrub pad, steel wool, or light grade sand paper before dyeing.<ref>[http://engsoc.queensu.ca/ceo/Purpling%20Guide_website.doc Jacket Purpling Guide]; URL last accessed [[September 19]], [[2006]]</ref>
-==Popular culture==
+|drugShortage=
-In [[Catch-22]], the medics are portrayed as using gentian violet on feet and gums as a [[universal panacea]].  During the 1940's in the US, tub soaks made with water and gentian violet were "prescribed" as a cure for poison ivy, though its efficacy in such an application is unsubstantiated.
+}}
+{{PillImage
+|fileName=No image.jpg
+}}
+{{LabelImage
+|fileName={{PAGENAME}}11.png
+}}
+{{LabelImage
+|fileName={{PAGENAME}}11.png
+}}
+<!--Pill Image-->
-==References==
-<references/>
-==See also==
-*[[Methylene blue]]
-*[[Prussian blue]]
-==External links==
+<!--Label Display Image-->
-* [http://www.lifelearning.org/2006/03/06/home-treatment-for-thrush-in-nursing-moms-and-babies/ Gentian Violet and Thrush]
-* [http://gentian.rutgers.edu/GentianViolet.htm  Gentian Violet]
-* [http://engsoc.queensu.ca/ceo/Purpling%20Guide_website.doc Jacket Purpling Guide]
-* [http://www.rwh.org.au/rwhcpg/maternity.cfm?doc_id=5870 Clinical Practice Guidelines]
+<!--Category-->
 [[Category:Antifungals]]
-[[Category:Disinfectants]]
+[[Category:Drug]]
-[[pl:Gencjana]]
-[[pt:Violeta de genciana]]
-{{WikiDoc Help Menu}}
-{{WikiDoc Sources}}

Gentian violet: Difference between revisions

Latest revision as of 15:51, 21 April 2015

Disclaimer

Overview

Adult Indications and Dosage

FDA-Labeled Indications and Dosage (Adult)

Indications

Off-Label Use and Dosage (Adult)

Guideline-Supported Use

Non–Guideline-Supported Use

Pediatric Indications and Dosage

FDA-Labeled Indications and Dosage (Pediatric)

Indications

Off-Label Use and Dosage (Pediatric)

Guideline-Supported Use

Non–Guideline-Supported Use

Contraindications

Warnings

Adverse Reactions

Clinical Trials Experience

Postmarketing Experience

Drug Interactions

Use in Specific Populations

Pregnancy

Labor and Delivery

Nursing Mothers

Pediatric Use

Geriatic Use

Gender

Race

Renal Impairment

Hepatic Impairment

Females of Reproductive Potential and Males

Immunocompromised Patients

Administration and Monitoring

Administration

Monitoring

IV Compatibility

Overdosage

Pharmacology

Mechanism of Action

Structure

Pharmacodynamics

Pharmacokinetics

Nonclinical Toxicology

Clinical Studies

How Supplied

Storage

Images

Drug Images

Package and Label Display Panel

Patient Counseling Information

Precautions with Alcohol

Brand Names

Look-Alike Drug Names

Drug Shortage Status

Price

References

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