GRIK1

Glutamate receptor, ionotropic, kainate 1
PDB rendering based on 1txf.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1txf​, 1ycj​, 2f34​, 2f35​, 2f36​, 2ojt​
Identifiers
Symbols	GRIK1 ; EAA3; EEA3; GLR5; GLUR5
External IDs	Template:OMIM5 Template:MGI HomoloGene: 68992
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Glutamate receptor, ionotropic, kainate 1, also known as GRIK1, is a human gene.

This gene encodes one of the many ionotropic glutamate receptor (GluR) subunits that function as ligand-gate ionic channels. The specific GluR subunit encoded by this gene is of the kainate receptor subtype. Receptor assembly and intracellular trafficking of ionotropic glutamate receptors are regulated by RNA editing and alternative splicing. These receptors mediate excitatory neurotransmission and are critical for normal synaptic function. Two alternatively spliced transcript variants that encode different isoforms have been described. Exons of this gene are interspersed with exons from the C21orf41 gene, which is transcribed in the same orientation as this gene but does not seem to encode a protein.

See also

• Kainate receptor

Further reading

• Nutt SL, Kamboj RK (1995). "RNA editing of human kainate receptor subunits". Neuroreport. 5 (18): 2625–9. PMID 7696618.
• Roche KW, Raymond LA, Blackstone C, Huganir RL (1994). "Transmembrane topology of the glutamate receptor subunit GluR6". J. Biol. Chem. 269 (16): 11679–82. PMID 8163463.CS1 maint: Multiple names: authors list (link)
• Gregor P, O'Hara BF, Yang X, Uhl GR (1994). "Expression and novel subunit isoforms of glutamate receptor genes GluR5 and GluR6". Neuroreport. 4 (12): 1343–6. PMID 8260617.CS1 maint: Multiple names: authors list (link)
• Eubanks JH, Puranam RS, Kleckner NW; et al. (1993). "The gene encoding the glutamate receptor subunit GluR5 is located on human chromosome 21q21.1-22.1 in the vicinity of the gene for familial amyotrophic lateral sclerosis". Proc. Natl. Acad. Sci. U.S.A. 90 (1): 178–82. PMID 8419920.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Potier MC, Dutriaux A, Lambolez B; et al. (1993). "Assignment of the human glutamate receptor gene GLUR5 to 21q22 by screening a chromosome 21 YAC library". Genomics. 15 (3): 696–7. doi:10.1006/geno.1993.1131. PMID 8468067.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Korczak B, Nutt SL, Fletcher EJ; et al. (1996). "cDNA cloning and functional properties of human glutamate receptor EAA3 (GluR5) in homomeric and heteromeric configuration". Recept. Channels. 3 (1): 41–9. PMID 8589992.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Brakeman PR, Lanahan AA, O'Brien R; et al. (1997). "Homer: a protein that selectively binds metabotropic glutamate receptors". Nature. 386 (6622): 284–8. doi:10.1038/386284a0. PMID 9069287.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sander T, Hildmann T, Kretz R; et al. (1997). "Allelic association of juvenile absence epilepsy with a GluR5 kainate receptor gene (GRIK1) polymorphism". Am. J. Med. Genet. 74 (4): 416–21. PMID 9259378.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Clarke VR, Ballyk BA, Hoo KH; et al. (1997). "A hippocampal GluR5 kainate receptor regulating inhibitory synaptic transmission". Nature. 389 (6651): 599–603. doi:10.1038/39315. PMID 9335499.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Xiao B, Tu JC, Petralia RS; et al. (1998). "Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins". Neuron. 21 (4): 707–16. PMID 9808458.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Montague AA, Greer CA (1999). "Differential distribution of ionotropic glutamate receptor subunits in the rat olfactory bulb". J. Comp. Neurol. 405 (2): 233–46. PMID 10023812.
• Bortolotto ZA, Clarke VR, Delany CM; et al. (1999). "Kainate receptors are involved in synaptic plasticity". Nature. 402 (6759): 297–301. doi:10.1038/46290. PMID 10580501.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Barbon A, Barlati S (2000). "Genomic organization, proposed alternative splicing mechanisms, and RNA editing structure of GRIK1". Cytogenet. Cell Genet. 88 (3–4): 236–9. PMID 10828597.
• Hattori M, Fujiyama A, Taylor TD; et al. (2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. doi:10.1038/35012518. PMID 10830953.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ango F, Prézeau L, Muller T; et al. (2001). "Agonist-independent activation of metabotropic glutamate receptors by the intracellular protein Homer". Nature. 411 (6840): 962–5. doi:10.1038/35082096. PMID 11418862.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shibata H, Joo A, Fujii Y; et al. (2002). "Association study of polymorphisms in the GluR5 kainate receptor gene (GRIK1) with schizophrenia". Psychiatr. Genet. 11 (3): 139–44. PMID 11702055.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hirbec H, Perestenko O, Nishimune A; et al. (2002). "The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs". J. Biol. Chem. 277 (18): 15221–4. doi:10.1074/jbc.C200112200. PMID 11891216.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Enz R (2002). "The actin-binding protein Filamin-A interacts with the metabotropic glutamate receptor type 7". FEBS Lett. 514 (2–3): 184–8. PMID 11943148.
• Hirbec H, Francis JC, Lauri SE; et al. (2003). "Rapid and differential regulation of AMPA and kainate receptors at hippocampal mossy fibre synapses by PICK1 and GRIP". Neuron. 37 (4): 625–38. PMID 12597860.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ren Z, Riley NJ, Needleman LA; et al. (2004). "Cell surface expression of GluR5 kainate receptors is regulated by an endoplasmic reticulum retention signal". J. Biol. Chem. 278 (52): 52700–9. doi:10.1074/jbc.M309585200. PMID 14527949.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

External links

• GRIK1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.