GRIA4
| Glutamate receptor, ionotrophic, AMPA 4 | |||||||||||
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| Identifiers | |||||||||||
| Symbols | GRIA4 ; GLUR4; GLUR4C; GLURD | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 20227 | ||||||||||
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| Species | Human | Mouse | |||||||||
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| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
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Glutamate receptor, ionotrophic, AMPA 4, also known as GRIA4, is a human gene.[1]
This gene is a member of a family of L-glutamate-gated ion channels that mediate fast synaptic excitatory neurotransmission. These channels are also responsive to the glutamate agonist, alpha-amino-3-hydroxy-5-methyl-4-isoxazolpropionate (AMPA). Some haplotypes of this gene show a positive association with schizophrenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[1]
See also
References
Further reading
- McNamara JO, Eubanks JH, McPherson JD; et al. (1992). "Chromosomal localization of human glutamate receptor genes". J. Neurosci. 12 (7): 2555–62. PMID 1319477.
- Hardy M, Younkin D, Tang CM; et al. (1994). "Expression of non-NMDA glutamate receptor channel genes by clonal human neurons". J. Neurochem. 63 (2): 482–9. PMID 7518497.
- Roche KW, Raymond LA, Blackstone C, Huganir RL (1994). "Transmembrane topology of the glutamate receptor subunit GluR6". J. Biol. Chem. 269 (16): 11679–82. PMID 8163463.
- Fletcher EJ, Nutt SL, Hoo KH; et al. (1996). "Cloning, expression and pharmacological characterization of a human glutamate receptor: hGluR4". Recept. Channels. 3 (1): 21–31. PMID 8589990.
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. PMID 8889548.
- Ripellino JA, Neve RL, Howe JR (1998). "Expression and heteromeric interactions of non-N-methyl-D-aspartate glutamate receptor subunits in the developing and adult cerebellum". Neuroscience. 82 (2): 485–97. PMID 9466455.
- Carvalho AL, Kameyama K, Huganir RL (1999). "Characterization of phosphorylation sites on the glutamate receptor 4 subunit of the AMPA receptors". J. Neurosci. 19 (12): 4748–54. PMID 10366608.
- Chen L, Chetkovich DM, Petralia RS; et al. (2001). "Stargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms". Nature. 408 (6815): 936–43. doi:10.1038/35050030. PMID 11140673.
- Hirbec H, Perestenko O, Nishimune A; et al. (2002). "The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs". J. Biol. Chem. 277 (18): 15221–4. doi:10.1074/jbc.C200112200. PMID 11891216.
- Tomiyama M, Rodríguez-Puertas R, Cortés R; et al. (2002). "Flip and flop splice variants of AMPA receptor subunits in the spinal cord of amyotrophic lateral sclerosis". Synapse. 45 (4): 245–9. doi:10.1002/syn.10098. PMID 12125045.
- Pasternack A, Coleman SK, Jouppila A; et al. (2003). "Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor channels lacking the N-terminal domain". J. Biol. Chem. 277 (51): 49662–7. doi:10.1074/jbc.M208349200. PMID 12393905.
- Correia SS, Duarte CB, Faro CJ; et al. (2003). "Protein kinase C gamma associates directly with the GluR4 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor subunit. Effect on receptor phosphorylation". J. Biol. Chem. 278 (8): 6307–13. doi:10.1074/jbc.M205587200. PMID 12471040.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Makino C, Fujii Y, Kikuta R; et al. (2003). "Positive association of the AMPA receptor subunit GluR4 gene (GRIA4) haplotype with schizophrenia: linkage disequilibrium mapping using SNPs evenly distributed across the gene region". Am. J. Med. Genet. B Neuropsychiatr. Genet. 116 (1): 17–22. doi:10.1002/ajmg.b.10041. PMID 12497607.
- Coleman SK, Cai C, Mottershead DG; et al. (2003). "Surface expression of GluR-D AMPA receptor is dependent on an interaction between its C-terminal domain and a 4.1 protein". J. Neurosci. 23 (3): 798–806. PMID 12574408.
- Pasternack A, Coleman SK, Féthière J; et al. (2003). "Characterization of the functional role of the N-glycans in the AMPA receptor ligand-binding domain". J. Neurochem. 84 (5): 1184–92. PMID 12603841.
- Kawahara Y, Ito K, Sun H; et al. (2004). "GluR4c, an alternative splicing isoform of GluR4, is abundantly expressed in the adult human brain". Brain Res. Mol. Brain Res. 127 (1–2): 150–5. doi:10.1016/j.molbrainres.2004.05.020. PMID 15306133.
- Li G, Sheng Z, Huang Z, Niu L (2005). "Kinetic mechanism of channel opening of the GluRDflip AMPA receptor". Biochemistry. 44 (15): 5835–41. doi:10.1021/bi047413n. PMID 15823042.
- Nuriya M, Oh S, Huganir RL (2005). "Phosphorylation-dependent interactions of alpha-Actinin-1/IQGAP1 with the AMPA receptor subunit GluR4". J. Neurochem. 95 (2): 544–52. doi:10.1111/j.1471-4159.2005.03410.x. PMID 16190873.
- Kimura K, Wakamatsu A, Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.
External links
- GRIA4+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.