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{{Infobox_gene}}
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'''Glucosamine-6-phosphate isomerase 1''' is an [[enzyme]] that in humans is encoded by the ''GNPDA1'' [[gene]].<ref name="pmid9714720">{{cite journal |vauthors=Shevchenko V, Hogben M, Ekong R, Parrington J, Lai FA | title = The human glucosamine-6-phosphate deaminase gene: cDNA cloning and expression, genomic organization and chromosomal localization | journal = Gene | volume = 216 | issue = 1 | pages = 31–8 |date=Oct 1998 | pmid = 9714720 | pmc =  | doi =10.1016/S0378-1119(98)00335-7 }}</ref><ref name="pmid9438414">{{cite journal |vauthors=Wolosker H, Kline D, Bian Y, Blackshaw S, Cameron AM, Fralich TJ, Schnaar RL, Snyder SH | title = Molecularly cloned mammalian glucosamine-6-phosphate deaminase localizes to transporting epithelium and lacks oscillin activity | journal = FASEB J | volume = 12 | issue = 1 | pages = 91–9 |date=Feb 1998 | pmid = 9438414 | pmc =  | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: GNPDA1 glucosamine-6-phosphate deaminase 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10007| accessdate = }}</ref>
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{{GNF_Protein_box
| image = PBB_Protein_GNPDA1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1ne7.
| PDB = {{PDB2|1ne7}}
| Name = Glucosamine-6-phosphate deaminase 1
| HGNCid = 4417
| Symbol = GNPDA1
| AltSymbols =; GPI; GNPI; GNPDA; HLN; KIAA0060
| OMIM = 601798
| ECnumber =
| Homologene = 38054
| MGIid = 1347054
  | GeneAtlas_image1 = PBB_GE_GNPDA1_202382_s_at_tn.png
  | Function = {{GNF_GO|id=GO:0004342 |text = glucosamine-6-phosphate deaminase activity}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}}
| Component =  
| Process = {{GNF_GO|id=GO:0005975 |text = carbohydrate metabolic process}} {{GNF_GO|id=GO:0006043 |text = glucosamine catabolic process}} {{GNF_GO|id=GO:0006044 |text = N-acetylglucosamine metabolic process}} {{GNF_GO|id=GO:0006091 |text = generation of precursor metabolites and energy}} {{GNF_GO|id=GO:0007338 |text = single fertilization}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10007
    | Hs_Ensembl = ENSG00000113552
    | Hs_RefseqProtein = NP_005462
    | Hs_RefseqmRNA = NM_005471
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 5
    | Hs_GenLoc_start = 141360422
    | Hs_GenLoc_end = 141372776
    | Hs_Uniprot = P46926
    | Mm_EntrezGene = 26384
    | Mm_Ensembl =   
    | Mm_RefseqmRNA = NM_011937
    | Mm_RefseqProtein = NP_036067
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr =   
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Glucosamine-6-phosphate deaminase 1''', also known as '''GNPDA1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GNPDA1 glucosamine-6-phosphate deaminase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10007| accessdate = }}</ref>
 
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==References==
{{reflist}}


==References==
{{reflist|2}}
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Weidanz JA, Campbell P, DeLucas LJ, ''et al.'' |title=Glucosamine 6-phosphate deaminase in normal human erythrocytes. |journal=Br. J. Haematol. |volume=91 |issue= 1 |pages= 72-9 |year= 1995 |pmid= 7577655 |doi=  }}
*{{cite journal  |vauthors=Weidanz JA, Campbell P, DeLucas LJ |title=Glucosamine 6-phosphate deaminase in normal human erythrocytes. |journal=Br. J. Haematol. |volume=91 |issue= 1 |pages= 72–9 |year= 1995 |pmid= 7577655 |doi=10.1111/j.1365-2141.1995.tb05247.x |display-authors=etal}}
*{{cite journal  | author=Nomura N, Nagase T, Miyajima N, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. |journal=DNA Res. |volume=1 |issue= 5 |pages= 223-9 |year= 1995 |pmid= 7584044 |doi=  }}
*{{cite journal  |vauthors=Nomura N, Nagase T, Miyajima N |title=Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. |journal=DNA Res. |volume=1 |issue= 5 |pages= 223–9 |year= 1995 |pmid= 7584044 |doi=10.1093/dnares/1.5.223 |display-authors=etal}}
*{{cite journal  | author=Oliva G, Fontes MR, Garratt RC, ''et al.'' |title=Structure and catalytic mechanism of glucosamine 6-phosphate deaminase from Escherichia coli at 2.1 A resolution. |journal=Structure |volume=3 |issue= 12 |pages= 1323-32 |year= 1996 |pmid= 8747459 |doi= }}
*{{cite journal  |vauthors=Oliva G, Fontes MR, Garratt RC |title=Structure and catalytic mechanism of glucosamine 6-phosphate deaminase from Escherichia coli at 2.1 A resolution. |journal=Structure |volume=3 |issue= 12 |pages= 1323–32 |year= 1996 |pmid= 8747459 |doi=10.1016/S0969-2126(01)00270-2 |display-authors=etal}}
*{{cite journal  | author=Wolosker H, Kline D, Bian Y, ''et al.'' |title=Molecularly cloned mammalian glucosamine-6-phosphate deaminase localizes to transporting epithelium and lacks oscillin activity. |journal=FASEB J. |volume=12 |issue= 1 |pages= 91-9 |year= 1998 |pmid= 9438414 |doi= }}
*{{cite journal  |vauthors=Nakamura Y, Miura K, Fujino Y |title=Evolution, structure, and expression of GNPI/Oscillin orthologous genes. |journal=Genomics |volume=68 |issue= 2 |pages= 179–86 |year= 2001 |pmid= 10964516 |doi= 10.1006/geno.2000.6287 |display-authors=etal}}
*{{cite journal  | author=Shevchenko V, Hogben M, Ekong R, ''et al.'' |title=The human glucosamine-6-phosphate deaminase gene: cDNA cloning and expression, genomic organization and chromosomal localization. |journal=Gene |volume=216 |issue= 1 |pages= 31-8 |year= 1998 |pmid= 9714720 |doi=  }}
*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Nakamura Y, Miura K, Fujino Y, ''et al.'' |title=Evolution, structure, and expression of GNPI/Oscillin orthologous genes. |journal=Genomics |volume=68 |issue= 2 |pages= 179-86 |year= 2001 |pmid= 10964516 |doi= 10.1006/geno.2000.6287 }}
*{{cite journal  |vauthors=Zhang J, Zhang W, Zou D |title=Cloning and functional characterization of GNPI2, a novel human homolog of glucosamine-6-phosphate isomerase/oscillin. |journal=J. Cell. Biochem. |volume=88 |issue= 5 |pages= 932–40 |year= 2003 |pmid= 12616532 |doi= 10.1002/jcb.10444 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  |vauthors=Arreola R, Valderrama B, Morante ML, Horjales E |title=Two mammalian glucosamine-6-phosphate deaminases: a structural and genetic study. |journal=FEBS Lett. |volume=551 |issue= 1-3 |pages= 63–70 |year= 2003 |pmid= 12965206 |doi=10.1016/S0014-5793(03)00896-2 }}
*{{cite journal  | author=Zhang J, Zhang W, Zou D, ''et al.'' |title=Cloning and functional characterization of GNPI2, a novel human homolog of glucosamine-6-phosphate isomerase/oscillin. |journal=J. Cell. Biochem. |volume=88 |issue= 5 |pages= 932-40 |year= 2003 |pmid= 12616532 |doi= 10.1002/jcb.10444 }}
*{{cite journal  |vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
*{{cite journal  | author=Arreola R, Valderrama B, Morante ML, Horjales E |title=Two mammalian glucosamine-6-phosphate deaminases: a structural and genetic study. |journal=FEBS Lett. |volume=551 |issue= 1-3 |pages= 63-70 |year= 2003 |pmid= 12965206 |doi=  }}
*{{cite journal  |vauthors=Schmutz J, Martin J, Terry A |title=The DNA sequence and comparative analysis of human chromosome 5. |journal=Nature |volume=431 |issue= 7006 |pages= 268–74 |year= 2004 |pmid= 15372022 |doi= 10.1038/nature02919 |display-authors=etal}}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  |vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Schmutz J, Martin J, Terry A, ''et al.'' |title=The DNA sequence and comparative analysis of human chromosome 5. |journal=Nature |volume=431 |issue= 7006 |pages= 268-74 |year= 2004 |pmid= 15372022 |doi= 10.1038/nature02919 }}
*{{cite journal  |vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |display-authors=etal}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
}}
}}
{{refend}}
{{refend}}


{{protein-stub}}
==External links==
{{WikiDoc Sources}}
* {{UCSC genome browser|GNPDA1}}
* {{UCSC gene details|GNPDA1}}
 
{{PDB Gallery|geneid=10007}}
 
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{{gene-5-stub}}

Latest revision as of 08:53, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Glucosamine-6-phosphate isomerase 1 is an enzyme that in humans is encoded by the GNPDA1 gene.[1][2][3]

References

  1. Shevchenko V, Hogben M, Ekong R, Parrington J, Lai FA (Oct 1998). "The human glucosamine-6-phosphate deaminase gene: cDNA cloning and expression, genomic organization and chromosomal localization". Gene. 216 (1): 31–8. doi:10.1016/S0378-1119(98)00335-7. PMID 9714720.
  2. Wolosker H, Kline D, Bian Y, Blackshaw S, Cameron AM, Fralich TJ, Schnaar RL, Snyder SH (Feb 1998). "Molecularly cloned mammalian glucosamine-6-phosphate deaminase localizes to transporting epithelium and lacks oscillin activity". FASEB J. 12 (1): 91–9. PMID 9438414.
  3. "Entrez Gene: GNPDA1 glucosamine-6-phosphate deaminase 1".

Further reading

External links