Difference between revisions of "GNAT1"

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'''Guanine nucleotide-binding protein G(t) subunit alpha-1''' is a [[protein]] that in humans is encoded by the ''GNAT1'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GNAT1 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2779| accessdate = }}</ref>
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{{GNF_Protein_box
 
| image = PBB_Protein_GNAT1_image.jpg
 
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1fqj.
 
| PDB = {{PDB2|1fqj}}, {{PDB2|1fqk}}, {{PDB2|1got}}, {{PDB2|1tad}}, {{PDB2|1tag}}, {{PDB2|1tnd}}
 
| Name = Guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1
 
| HGNCid = 4393
 
| Symbol = GNAT1
 
| AltSymbols =; GBT1; GNATR
 
| OMIM = 139330
 
| ECnumber = 
 
| Homologene = 20084
 
| MGIid = 95778
 
| GeneAtlas_image1 = PBB_GE_GNAT1_214286_at_tn.png
 
| GeneAtlas_image2 = PBB_GE_GNAT1_207514_s_at_tn.png
 
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003924 |text = GTPase activity}} {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0005525 |text = GTP binding}}
 
| Component =
 
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007601 |text = visual perception}} {{GNF_GO|id=GO:0007602 |text = phototransduction}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}}
 
| Orthologs = {{GNF_Ortholog_box
 
    | Hs_EntrezGene = 2779
 
    | Hs_Ensembl = ENSG00000114349
 
    | Hs_RefseqProtein = NP_000163
 
    | Hs_RefseqmRNA = NM_000172
 
    | Hs_GenLoc_db = 
 
    | Hs_GenLoc_chr = 3
 
    | Hs_GenLoc_start = 50204047
 
    | Hs_GenLoc_end = 50208953
 
    | Hs_Uniprot = P11488
 
    | Mm_EntrezGene = 14685
 
    | Mm_Ensembl = ENSMUSG00000034837
 
    | Mm_RefseqmRNA = NM_008140
 
    | Mm_RefseqProtein = NP_032166
 
    | Mm_GenLoc_db = 
 
    | Mm_GenLoc_chr = 9
 
    | Mm_GenLoc_start = 107532576
 
    | Mm_GenLoc_end = 107537716
 
    | Mm_Uniprot = P20612
 
  }}
 
}}
 
'''Guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1''', also known as '''GNAT1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GNAT1 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2779| accessdate = }}</ref>
 
  
 
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{{PBB_Summary
 
| section_title =  
 
| section_title =  
| summary_text = Transducin is a 3-subunit guanine nucleotide-binding protein (G protein) which stimulates the coupling of rhodopsin and cGMP-phoshodiesterase during visual impulses. The transducin alpha subunits in rods and cones are encoded by separate genes. This gene encodes the alpha subunit in rods. Alternative splicing of this gene results in two transcript variants.<ref name="entrez">{{cite web | title = Entrez Gene: GNAT1 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2779| accessdate = }}</ref>
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| summary_text = Transducin is a 3-subunit guanine nucleotide-binding protein (G protein) which stimulates the coupling of rhodopsin and cGMP-phosphodiesterase during visual impulses. The transducin alpha subunits in rods and cones are encoded by separate genes. This gene encodes the alpha subunit in rods. Alternative splicing of this gene results in two transcript variants.<ref name="entrez">{{cite web | title = Entrez Gene: GNAT1 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2779| accessdate = }}</ref>
 
}}
 
}}
  
 
==References==
 
==References==
{{reflist|2}}
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{{reflist}}
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==Further reading==
 
==Further reading==
 
{{refbegin | 2}}
 
{{refbegin | 2}}
 
{{PBB_Further_reading  
 
{{PBB_Further_reading  
 
| citations =  
 
| citations =  
*{{cite journal  | author=Wilkie TM, Gilbert DJ, Olsen AS, ''et al.'' |title=Evolution of the mammalian G protein alpha subunit multigene family. |journal=Nat. Genet. |volume=1 |issue= 2 |pages= 85-91 |year= 1993 |pmid= 1302014 |doi= 10.1038/ng0592-85 }}
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*{{cite journal  |vauthors=Wilkie TM, Gilbert DJ, Olsen AS |title=Evolution of the mammalian G protein alpha subunit multigene family. |journal=Nat. Genet. |volume=1 |issue= 2 |pages= 85–91 |year= 1993 |pmid= 1302014 |doi= 10.1038/ng0592-85 |display-authors=etal}}
*{{cite journal  | author=Bourne HR, Sanders DA, McCormick F |title=The GTPase superfamily: conserved structure and molecular mechanism. |journal=Nature |volume=349 |issue= 6305 |pages= 117-27 |year= 1991 |pmid= 1898771 |doi= 10.1038/349117a0 }}
+
*{{cite journal  |vauthors=Bourne HR, Sanders DA, McCormick F |title=The GTPase superfamily: conserved structure and molecular mechanism. |journal=Nature |volume=349 |issue= 6305 |pages= 117–27 |year= 1991 |pmid= 1898771 |doi= 10.1038/349117a0 }}
*{{cite journal  | author=Fong SL |title=Characterization of the human rod transducin alpha-subunit gene. |journal=Nucleic Acids Res. |volume=20 |issue= 11 |pages= 2865-70 |year= 1992 |pmid= 1614872 |doi=  }}
+
*{{cite journal  | author=Fong SL |title=Characterization of the human rod transducin alpha-subunit gene. |journal=Nucleic Acids Res. |volume=20 |issue= 11 |pages= 2865–70 |year= 1992 |pmid= 1614872 |doi=10.1093/nar/20.11.2865  | pmc=336934 }}
*{{cite journal  | author=Lerea CL, Bunt-Milam AH, Hurley JB |title=Alpha transducin is present in blue-, green-, and red-sensitive cone photoreceptors in the human retina. |journal=Neuron |volume=3 |issue= 3 |pages= 367-76 |year= 1990 |pmid= 2534964 |doi=  }}
+
*{{cite journal  |vauthors=Lerea CL, Bunt-Milam AH, Hurley JB |title=Alpha transducin is present in blue-, green-, and red-sensitive cone photoreceptors in the human retina. |journal=Neuron |volume=3 |issue= 3 |pages= 367–76 |year= 1990 |pmid= 2534964 |doi=10.1016/0896-6273(89)90261-4 }}
*{{cite journal  | author=Van Dop C, Medynski DC, Apone LM |title=Nucleotide sequence for a cDNA encoding the alpha subunit of retinal transducin (GNAT1) isolated from the human eye. |journal=Nucleic Acids Res. |volume=17 |issue= 12 |pages= 4887 |year= 1989 |pmid= 2748346 |doi=  }}
+
*{{cite journal  |vauthors=Van Dop C, Medynski DC, Apone LM |title=Nucleotide sequence for a cDNA encoding the alpha subunit of retinal transducin (GNAT1) isolated from the human eye. |journal=Nucleic Acids Res. |volume=17 |issue= 12 |pages= 4887 |year= 1989 |pmid= 2748346 |doi=10.1093/nar/17.12.4887  | pmc=318051 }}
*{{cite journal  | author=Blatt C, Eversole-Cire P, Cohn VH, ''et al.'' |title=Chromosomal localization of genes encoding guanine nucleotide-binding protein subunits in mouse and human. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=85 |issue= 20 |pages= 7642-6 |year= 1988 |pmid= 2902634 |doi=  }}
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*{{cite journal  |vauthors=Blatt C, Eversole-Cire P, Cohn VH |title=Chromosomal localization of genes encoding guanine nucleotide-binding protein subunits in mouse and human. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=85 |issue= 20 |pages= 7642–6 |year= 1988 |pmid= 2902634 |doi=10.1073/pnas.85.20.7642  | pmc=282248 |display-authors=etal}}
*{{cite journal  | author=Ngo JT, Bateman JB, Klisak I, ''et al.'' |title=Regional mapping of a human rod alpha-transducin (GNAT1) gene to chromosome 3p22. |journal=Genomics |volume=18 |issue= 3 |pages= 724-5 |year= 1994 |pmid= 8307584 |doi=  }}
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*{{cite journal  |vauthors=Ngo JT, Bateman JB, Klisak I |title=Regional mapping of a human rod alpha-transducin (GNAT1) gene to chromosome 3p22. |journal=Genomics |volume=18 |issue= 3 |pages= 724–5 |year= 1994 |pmid= 8307584 |doi=10.1016/S0888-7543(05)80384-2 |display-authors=etal}}
*{{cite journal  | author=Dryja TP, Hahn LB, Reboul T, Arnaud B |title=Missense mutation in the gene encoding the alpha subunit of rod transducin in the Nougaret form of congenital stationary night blindness. |journal=Nat. Genet. |volume=13 |issue= 3 |pages= 358-60 |year= 1996 |pmid= 8673138 |doi= 10.1038/ng0796-358 }}
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*{{cite journal  |vauthors=Dryja TP, Hahn LB, Reboul T, Arnaud B |title=Missense mutation in the gene encoding the alpha subunit of rod transducin in the Nougaret form of congenital stationary night blindness. |journal=Nat. Genet. |volume=13 |issue= 3 |pages= 358–60 |year= 1996 |pmid= 8673138 |doi= 10.1038/ng0796-358 }}
*{{cite journal  | author=Chen CK, Wieland T, Simon MI |title=RGS-r, a retinal specific RGS protein, binds an intermediate conformation of transducin and enhances recycling. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 23 |pages= 12885-9 |year= 1996 |pmid= 8917514 |doi=  }}
+
*{{cite journal  |vauthors=Chen CK, Wieland T, Simon MI |title=RGS-r, a retinal specific RGS protein, binds an intermediate conformation of transducin and enhances recycling. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 23 |pages= 12885–9 |year= 1996 |pmid= 8917514 |doi=10.1073/pnas.93.23.12885  | pmc=24015 }}
*{{cite journal  | author=Seibert C, Harteneck C, Ernst OP, ''et al.'' |title=Activation of the rod G-protein Gt by the thrombin receptor (PAR1) expressed in Sf9 cells. |journal=Eur. J. Biochem. |volume=266 |issue= 3 |pages= 911-6 |year= 2000 |pmid= 10583385 |doi=  }}
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*{{cite journal  |vauthors=Seibert C, Harteneck C, Ernst OP |title=Activation of the rod G-protein Gt by the thrombin receptor (PAR1) expressed in Sf9 cells. |journal=Eur. J. Biochem. |volume=266 |issue= 3 |pages= 911–6 |year= 2000 |pmid= 10583385 |doi=10.1046/j.1432-1327.1999.00927.x |display-authors=etal}}
*{{cite journal  | author=Wieland T, Bahtijari N, Zhou XB, ''et al.'' |title=Polarity exchange at the interface of regulators of G protein signaling with G protein alpha-subunits. |journal=J. Biol. Chem. |volume=275 |issue= 37 |pages= 28500-6 |year= 2000 |pmid= 10878019 |doi= 10.1074/jbc.M004187200 }}
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*{{cite journal  |vauthors=Wieland T, Bahtijari N, Zhou XB |title=Polarity exchange at the interface of regulators of G protein signaling with G protein alpha-subunits. |journal=J. Biol. Chem. |volume=275 |issue= 37 |pages= 28500–6 |year= 2000 |pmid= 10878019 |doi= 10.1074/jbc.M004187200 |display-authors=etal}}
*{{cite journal  | author=Bell MW, Desai N, Guo XX, Ghalayini AJ |title=Tyrosine phosphorylation of the alpha subunit of transducin and its association with Src in photoreceptor rod outer segments. |journal=J. Neurochem. |volume=75 |issue= 5 |pages= 2006-19 |year= 2000 |pmid= 11032890 |doi=  }}
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*{{cite journal  |vauthors=Bell MW, Desai N, Guo XX, Ghalayini AJ |title=Tyrosine phosphorylation of the alpha subunit of transducin and its association with Src in photoreceptor rod outer segments. |journal=J. Neurochem. |volume=75 |issue= 5 |pages= 2006–19 |year= 2000 |pmid= 11032890 |doi=10.1046/j.1471-4159.2000.0752006.x }}
*{{cite journal  | author=Hu G, Wensel TG |title=R9AP, a membrane anchor for the photoreceptor GTPase accelerating protein, RGS9-1. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 15 |pages= 9755-60 |year= 2002 |pmid= 12119397 |doi= 10.1073/pnas.152094799 }}
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*{{cite journal  |vauthors=Hu G, Wensel TG |title=R9AP, a membrane anchor for the photoreceptor GTPase accelerating protein, RGS9-1. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 15 |pages= 9755–60 |year= 2002 |pmid= 12119397 |doi= 10.1073/pnas.152094799 | pmc=125004 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+
*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
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*{{cite journal  |vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Muzny DM, Scherer SE, Kaul R, ''et al.'' |title=The DNA sequence, annotation and analysis of human chromosome 3. |journal=Nature |volume=440 |issue= 7088 |pages= 1194-8 |year= 2006 |pmid= 16641997 |doi= 10.1038/nature04728 }}
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*{{cite journal  |vauthors=Muzny DM, Scherer SE, Kaul R |title=The DNA sequence, annotation and analysis of human chromosome 3. |journal=Nature |volume=440 |issue= 7088 |pages= 1194–8 |year= 2006 |pmid= 16641997 |doi= 10.1038/nature04728 |display-authors=etal}}
 
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Latest revision as of 08:51, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

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n/a

RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Guanine nucleotide-binding protein G(t) subunit alpha-1 is a protein that in humans is encoded by the GNAT1 gene.[1]

Transducin is a 3-subunit guanine nucleotide-binding protein (G protein) which stimulates the coupling of rhodopsin and cGMP-phosphodiesterase during visual impulses. The transducin alpha subunits in rods and cones are encoded by separate genes. This gene encodes the alpha subunit in rods. Alternative splicing of this gene results in two transcript variants.[1]

References

  1. 1.0 1.1 "Entrez Gene: GNAT1 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1".

Further reading